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The aim of this study was to evaluate expression of the natural anti-oxidants paraoxonase (PON) 1 (zeige PON1 Antikörper), 2 and 3 in granulosa cells and PON1 (zeige PON1 Antikörper) activity in follicular fluid and plasma of dairy cows.
Our study showed that although lipoic acid up-regulates PON3 but down-regulates PON1 (zeige PON1 Antikörper) mRNA expression, it increases both PON1 (zeige PON1 Antikörper) and PON3 protein levels and arylesterase activity in HepG2 cells. We can report that lipoic acid may be useful for preventing atherosclerosis at therapeutic doses.
Data suggest that paraoxonases (PON1 (zeige PON1 Antikörper), PON2 (zeige PON2 Antikörper), PON3) play roles in innate immunity, inflammatory response, and protection against oxidative stress; these factors are associated with the body's response to infectious diseases; low serum PON1 (zeige PON1 Antikörper) activities are associated with poor survival in patients with severe sepsis. [REVIEW]
Data show that the mRNA levels of both paraoxonases PON2 (zeige PON2 Antikörper) and PON3 were significantly upregulated whereas PON1 (zeige PON1 Antikörper)'s mRNA was absent in transgenic mouse hearts.
Although inappropriate promoter methylation was not invariantly associated with reduced transcript expression, a significant association was apparent for the ARHGEF4 (zeige ARHGEF4 Antikörper), PON3, STAT5a (zeige STAT5A Antikörper), and VAX2 (zeige VAX2 Antikörper) gene transcripts (P<0.05). Herein, we present the first genome-wide DNA methylation (zeige HELLS Antikörper) analysis in a unique HG-NMIBC cohort, showing extensive and discrete methylation changes relative to normal bladder and low-intermediate-grade tumor
Low PON3 expression is associated with hepatocellular carcinoma progression.
This study showed that the PI3K (zeige PIK3CA Antikörper)/Akt (zeige AKT1 Antikörper) pathway is up-regulated by the expression of PON3 in oral squamous cell carcinoma by AP-1 (zeige FOSB Antikörper).
Studies indicate that three paraoxonases PON1 (zeige PON1 Antikörper), PON2 (zeige PON2 Antikörper), and PON3 genes are clustered on chromosome 7, and that PONs possess numerous atheroprotective properties.
PON3 SNP rs13226149 was associated with intracerebral hemorrhage in log-additive and dominant models. The A allele of rs13226149 contributed to the decreased risk of ICH (zeige COL4a2 Antikörper). SNP rs1053275 was not associated with ICH (zeige COL4a2 Antikörper).
Data suggest cigarette smoke leads to inhibition of hydrolytic activity of paraoxonase isoenzymes (PON1 (zeige PON1 Antikörper), PON2 (zeige PON2 Antikörper), PON3) by modification of thiol groups, by interactions with free radicals/heavy metals, or by decreasing HDL (zeige HSD11B1 Antikörper) level in blood. [REVIEW]
Interaction of PON-3 and PON-1 (zeige PON1 Antikörper) and HDL (zeige HSD11B1 Antikörper) are associated with the presence and severity of coronary artery disease in type 2 diabetes mellitus patients.
study suggests a role for PON3 in the metabolism of lipid and bile acid as well as protection against atherosclerosis, gallstone disease, and obesity
PON3 is upregulated in cancer tissues and protects against mitochondrial superoxide-mediated cell death.
investigation of effect of knockout of Pon3 in embryo: Data suggest that Pon3-/- mice exhibit increased early embryonic and neonatal mortality.
mouse Pon3 is expressed in a wide range of tissues, and that its expression is temporally controlled
PON3 proteins were present in the vast majority of tissues investigated. mRNA for these proteins was also expressed in most of these tissues suggesting local production and the ability to respond in situ to inflammatory stimuli.
The anti-atherogenic biological activities were studied in vitro using serum or cell cultures, and also in vivo, using PON 1 (zeige PON1 Antikörper)/2/3 knockout or transgenic mice, as well as humans - healthy volunteers and atherosclerotic patients.
The directed evolution and characterization of recombinant variants of serum paraoxonase PON3, is described.
Results show that PON3 mRNA and protein are ubiquitously expressed in pig tissues. Moreover, the relative abundance of PON3 mRNA, measured in perirenal and subcutaneous fat tissues, is higher in obese gilts compared with the leaner (zeige CACNA1A Antikörper) gilts.
This gene is a member of the paraoxonase family and lies in a cluster on chromosome 7 with the other two family members. The encoded protein is secreted into the bloodstream and associates with high-density lipoprotein (HDL). The protein also rapidly hydrolyzes lactones and can inhibit the oxidation of low-density lipoprotein (LDL), a function that is believed to slow the initiation and progression of atherosclerosis. Alternatively spliced variants which encode different protein isoforms have been described\; however, only one has been fully characterized.
, serum paraoxonase/lactonase 3-like
, serum paraoxonase/lactonase 3