Peroxisomal Biogenesis Factor 5 ELISA Kits (PEX5)
Auf finden Sie aktuell 0 Peroxisomal Biogenesis Factor 5 (PEX5) ELISA Kits von unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen PEX5 Antikörper (44) und PEX5 Proteine (5) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 54 PEX5 Produkte verfügbar.
AW212715, ESTM1, PBD2A, PBD2B, Peroxin-5, PTS1-BP, PTS1R, PXR1, X83306
list all ELISA KIts Gen GeneID UniProt
Maus PEX5 PEX5 19305 O09012
Ratte PEX5 PEX5 312703 Q2M2R8
Human PEX5 PEX5 5830 P50542

Weitere Synonyme anzeigen

Weitere ELISA Kits für PEX5 Interaktionspartner

Mouse (Murine) Peroxisomal Biogenesis Factor 5 (PEX5) Interaktionspartner

  1. monoubiquitination of the N-terminal cysteine of peroxisome-associated PEX5 not only functions to recycle the peroxin back to the cytosol, but also serves as a quality control mechanism to eliminate peroxisomes with a defective protein import machinery

  2. Demyelination in cerebellum and brain stem preceded major myelin loss in corpus callosum of Pex5 deficient mice.

  3. interaction of PEX5 with catalase (zeige CAT ELISA Kits) and PEX14 (zeige PEX14 ELISA Kits)

  4. Peroxisomes were selectively reconstituted in brain or liver of Pex5 knock-out mice, a model for Zellweger syndrome (zeige PEX1 ELISA Kits), by tissue-selective overexpression of Pex5p. We found that both rescue strains exhibited a correction of the neuronal migration defect

Human Peroxisomal Biogenesis Factor 5 (PEX5) Interaktionspartner

  1. TRIM37 (zeige TRIM37 ELISA Kits)-mediated ubiquitylation stabilizes PEX5 and promotes peroxisomal matrix protein import, suggesting that mulibrey nanism is a new peroxisomal biogenesis disorder.

  2. Data suggest that soluble/cytosolic PEX5 interacts with PEX14 (zeige PEX14 ELISA Kits)/PEX13 (zeige PEX13 ELISA Kits) complex, a model for the docking/translocation module (DTM) of the peroxisomal matrix protein translocon; PEX14 (zeige PEX14 ELISA Kits)/PEX13 (zeige PEX13 ELISA Kits) complex appears to function in peroxisomal membrane as large cavity into which cytosolic PEX5 can enter to release its cargo. (PEX (zeige PHEX ELISA Kits) = peroxisomal biogenesis factor)

  3. data reveal subpopulations of peroxisomes showing only weak colocalization between PEX14 (zeige PEX14 ELISA Kits) and PEX5 or PEX11 but at the same time a clear compartmentalized organization. This compartmentalization, which was less evident in cases of strong colocalization, indicates dynamic protein reorganization linked to changes occurring in the peroxisomes.

  4. our data suggest that insertion of the trimeric PEX5-PEX7 (zeige PEX7 ELISA Kits)-PTS2 protein complex into the DTM is probably accompanied by conformational alterations in PEX5 to allow release of the PTS2 protein into the organelle matrix

  5. Our data suggest that the functional polymorphism rs3814058C>T in 3'-UTR (zeige UTS2R ELISA Kits) of PXR (zeige NR1I2 ELISA Kits) may be a functional biomarker to predict risk of colorectal cancer

  6. PEX5 encodes two isoforms, PEX5L & PEX5S, & a homozygous frame shift mutation c.722dupA (p.Val242Glyfs( *)33), located in the PEX5L-specific exon 9, results in loss of PEX5L only. Loss of PEX5L results in deficient import of PTS2-tagged proteins

  7. bulky side chain within the recognition motif, which blocks contraction of the PEX5 binding cavity

  8. Data show that ataxia-telangiectasia mutated (ATM (zeige ATM ELISA Kits)) phosphorylates peroxisomal biogenesis factor 5 (PEX5) at serine 141 in response to reactive oxygen species.

  9. ubiquitination of peroxisome-targeting signal type 1 (PTS1) receptor Pex5p regulating PTS1 protein import

  10. PEX5 has a role in regulating peroxisome numbers by signaling to mediate pexophagy

PEX5 Antigen-Profil

Beschreibung des Gens

The product of this gene binds to the C-terminal PTS1-type tripeptide peroxisomal targeting signal (SKL-type) and plays an essential role in peroxisomal protein import. Peroxins (PEXs) are proteins that are essential for the assembly of functional peroxisomes. The peroxisome biogenesis disorders (PBDs) are a group of genetically heterogeneous autosomal recessive, lethal diseases characterized by multiple defects in peroxisome function. The peroxisomal biogenesis disorders are a heterogeneous group with at least 14 complementation groups and with more than 1 phenotype being observed in cases falling into particular complementation groups. Although the clinical features of PBD patients vary, cells from all PBD patients exhibit a defect in the import of one or more classes of peroxisomal matrix proteins into the organelle. Defects in this gene are a cause of neonatal adrenoleukodystrophy (NALD), a cause of Zellweger syndrome (ZWS) as well as may be a cause of infantile Refsum disease (IRD). Alternatively spliced transcript variants encoding different isoforms have been identified.

Alternative names and synonyms associated with PEX5

  • peroxisomal biogenesis factor 5 (pex5) Elisa Kit
  • peroxisomal biogenesis factor 5 (Pex5) Elisa Kit
  • peroxisomal biogenesis factor 5 (PEX5) Elisa Kit
  • AW212715 Elisa Kit
  • ESTM1 Elisa Kit
  • PBD2A Elisa Kit
  • PBD2B Elisa Kit
  • Peroxin-5 Elisa Kit
  • PTS1-BP Elisa Kit
  • PTS1R Elisa Kit
  • PXR1 Elisa Kit
  • X83306 Elisa Kit

Bezeichner auf Proteinebene für PEX5

peroxisome biogenesis factor 5 , PTS1 receptor , PTS1-BP , PXR1P , peroxin 5 , peroxisomal C-terminal targeting signal import receptor , peroxisomal targeting signal 1 receptor , peroxisome receptor 1 , peroxin-5 , peroxisomal targeting signal 1 (SKL type) receptor , peroxisomal targeting signal import receptor , peroxisomal targeting signal receptor 1 , PTS1R , Peroxisomal C-terminal targeting signal import receptor , Peroxisome receptor 1

496849 Xenopus (Silurana) tropicalis
19305 Mus musculus
312703 Rattus norvegicus
5830 Homo sapiens
486710 Canis lupus familiaris
514832 Bos taurus
418299 Gallus gallus
100135597 Cavia porcellus
100689015 Cricetulus griseus
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