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anti-Human HSD17B4 Antikörper:
anti-Mouse (Murine) HSD17B4 Antikörper:
anti-Rat (Rattus) HSD17B4 Antikörper:
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Human Polyclonal HSD17B4 Primary Antibody für ICC, IF - ABIN4319880
Naudí, Cabré, Dominguez-Gonzalez, Ayala, Jové, Mota-Martorell, Piñol-Ripoll, Gil-Villar, Rué, Portero-Otín, Ferrer, Pamplona: Region-specific vulnerability to lipid peroxidation and evidence of neuronal mechanisms for polyunsaturated fatty acid biosynthesis in the healthy adult human central nervous system. in Biochimica et biophysica acta 2017
The knockdown of dbp (zeige GC Antikörper) in zebrafish phenocopied clinical manifestations of its deficiency in human.
Molecular models of domain structure of MFE-2 from human, C. elegans, and Drosophila melanogaster lend support to possible structural role of MFE-2 domains including SCP (zeige UCN3 Antikörper)-2L (sterol carrier protein 2 (zeige SCP2 Antikörper)-like) domain in human and C. elegans proteins.
This study reveals a crosstalk between acetylation and chaperone-mediated autophagy degradation in HSD17B4 regulation.
we identified that methylation of the promoter CpG island of HSD17B4 was associated with the pathological complete response of HER2 (zeige ERBB2 Antikörper)-positive breast cancer to trastuzumab and chemotherapy with a specificity of 79%
Our findings supported that HSD17B4 was one of the genes contributing to Perrault syndrome in this consanguineous Chinese Han family.
ere we present eight families affected by Perrault syndrome. In five families we identified novel or previously reported variants in HSD17B4, LARS2 (zeige LARS2 Antikörper), CLPP (zeige CLPP Antikörper) and C10orf2 (zeige C10ORF2 Antikörper)
Results show that HSD17B4 is highly expressed in hepatocellular carcinoma (HCC (zeige FAM126A Antikörper)) cells and activated NF-kappaB (zeige NFKB1 Antikörper) co-localized with the NF-kappaB (zeige NFKB1 Antikörper)-responsive element of HSD17B4 suggesting that HSD17B4 plays an important role in aggravated HCC (zeige FAM126A Antikörper) progression.
Structural MFE-2 instability is the molecular basis of D-bifunctional protein deficiency type III.
Specific combination of compound heterozygous mutations in 17beta-hydroxysteroid dehydrogenase (zeige HSD17B7 Antikörper) type 4 (HSD17B4) defines a new subtype of D-bifunctional protein deficiency.
Molecular models of domain structure of MFE-2 from human, C. elegans, and Drosophila melanogaster lend support to possible structural role of MFE-2 domains including SCP (zeige RAG1AP1 Antikörper)-2L (sterol carrier protein 2 (zeige SCP2 Antikörper)-like) domain in human and C. elegans proteins.
Epistasis between the HSD17B4 and thyroglobulin (zeige TG Antikörper) polymorphisms is associated with premature ovarian failure. A haplotype in the HSD17B4 gene was identified that was significantly associated with resistance to POF (zeige POF1B Antikörper)
The diagnosis of a type III DBPD with a missense mutation (T15A) in the HSD17B4 gene, coding for D-bifunctional protein (DBP), could be established.
Peroxisomal multifunctional protein-2 deficiency causes neuroinflammation and degeneration of Purkinje cells independent of very long chain fatty acid accumulation in mice.
bile acid biosynthesis, estimated by the ratio of C27/C24-bile acids, is more severely affected in double knock-out mice as compared with DBP (zeige GC Antikörper)-/- mice but was normal in LBP (zeige LBP Antikörper)-/- mice
Peroxisomal multifunctional protein 2 is essential for lipid homeostasis in Sertoli cells and male fertility
Loss of MFP2 leads to attenuation of up-regulations of SREBP2 (zeige SREBF2 Antikörper) and HMGCR (zeige HMGCR Antikörper) involved in cholesterol synthesis.
Leptin (zeige LEP Antikörper) in elevated doses, by stimulatory effect on CYP11A1 (zeige CYP11A1 Antikörper) and 17b-HSD (zeige HAL Antikörper) protein expression resulting in elevated P(4) and testosterone secretions could be an independent risk factor for cyst formation in both prepubertal and cycling pigs.
The protein encoded by this gene is a bifunctional enzyme that is involved in the peroxisomal beta-oxidation pathway for fatty acids. It also acts as a catalyst for the formation of 3-ketoacyl-CoA intermediates from both straight-chain and 2-methyl-branched-chain fatty acids. Defects in this gene that affect the peroxisomal fatty acid beta-oxidation activity are a cause of D-bifunctional protein deficiency (DBPD). An apparent pseudogene of this gene is present on chromosome 8.
peroxisomal multifunctional enzyme type 2
, 17-beta-HSD 4
, 17-beta-HSD IV
, 17-beta-hydroxysteroid dehydrogenase 4
, 17beta-estradiol dehydrogenase type IV
, 3-alpha,7-alpha,12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA hydratase
, D-3-hydroxyacyl-CoA dehydratase
, D-bifunctional protein, peroxisomal
, beta-hydroxyacyl dehydrogenase
, multifunctional protein 2
, peroxisomal multifunctional protein 2
, short chain dehydrogenase/reductase family 8C, member 1
, D-bifunctional protein
, peroxisomal multifunctional enzyme type II
, 17-beta-hydroxysteroid dehydrogenase type IV
, 17beta-estradiol dehydrogenase
, mutifunctional protein2