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The Alanine-glyoxylate aminotransferase 2 p.V498L polymorphism is associated with both paroxysmal and chronic forms of atrial fibrillation in coronary angiographic patients without structural heart disease in ultrasound, and earlier age at onset of ischemic stroke in patients undergoing exercise stress testing.
AGXT2 rs37369 polymorphism is associated with increased risk for CHD (zeige CHDH Proteine) in smokers and in diabetes mellitus patients
The AGXT2 genotype may be an important factor underlying atherosclerosis.
The results of this study that the AGXT2 gene is not associated with schizophrenia in Japanese subjects.
SNPs of AGXT2 affect plasma as well as urinary BAIB.
AGXT2 has an important role in SDMA metabolism in humans and may additionally have an unanticipated role in the autonomic nervous system regulation of cardiac function.
Alanine-glyoxylate aminotransferase-2 metabolizes endogenous methylarginines, regulates NO, and controls blood pressure.
mitochondrially localized human AGXT2 is able to effectively metabolize ADMA in vivo resulting in decreased ADMA levels and improved endothelial NO production.
In this work, we describe an assay for the AGXT2 activity in mouse liver and kidney tissue. The overall production rates of DMGV-d(6) in mice were 195.37 pmol/min/mg total protein in liver and 85.21 pmol/min/mg total protein in kidney tissue.
The protein encoded by this gene is a class III pyridoxal-phosphate-dependent mitochondrial aminotransferase. It catalyzes the conversion of glyoxylate to glycine using L-alanine as the amino donor.
, alanine--glyoxylate aminotransferase 2, mitochondrial
, beta-ALAAT II
, beta-alanine-pyruvate aminotransferase
, AGT 2
, alanine-glyoxylate aminotransferase 2