anti-Abcd2 (Abcd2) Antikörper

Bezeichnung:
anti-ATP-Binding Cassette, Sub-Family D (ALD), Member 2 Antikörper (Abcd2)
Auf www.antikoerper-online.de finden Sie aktuell 25 ATP-Binding Cassette, Sub-Family D (ALD), Member 2 (Abcd2) Antikörper von 3 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 28 Abcd2 Produkte verfügbar.
Synonyme:
ABC39, ALDL1, ALDR, ALDRP, DDBDRAFT_0214891, DDBDRAFT_0219834, DDB_0214891, DDB_0219834, hALDR

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anti-Human Abcd2 Antikörper:

anti-Mouse (Murine) Abcd2 Antikörper:

anti-Rat (Rattus) Abcd2 Antikörper:

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Am meisten referenzierte anti-Abcd2 Antikörper

  1. Human Polyclonal Abcd2 Primary Antibody für EIA, WB - ABIN950204 : Saito, Kawamoto, Kamatani: Association study between single-nucleotide polymorphisms in 199 drug-related genes and commonly measured quantitative traits of 752 healthy Japanese subjects. in Journal of human genetics 2009 (PubMed)
    Zeige alle 3 Referenzen für 950204

  2. Human Polyclonal Abcd2 Primary Antibody für EIA, WB - ABIN950203 : Maier, Mayerhofer, Asheuer, Köhler, Rothe, Muntau, Roscher, Holzinger, Aubourg, Berger: X-linked adrenoleukodystrophy phenotype is independent of ABCD2 genotype. in Biochemical and biophysical research communications 2008 (PubMed)
    Zeige alle 2 Referenzen für 950203

Weitere Antikörper gegen Abcd2 Interaktionspartner

Human ATP-Binding Cassette, Sub-Family D (ALD), Member 2 (Abcd2) Interaktionspartner

  1. ABCD1 (zeige ABCD1 Antikörper) and ABCD2 are involved in the transport of long and very long chain fatty acids (VLCFA) or their CoA-derivatives into peroxisomes with different substrate specificities, while ABCD3 (zeige ABCD3 Antikörper) is involved in the transport of branched chain acyl-CoA (zeige GNPAT Antikörper) into peroxisomes.ABCD4 is deduced to take part in the transport of vitamin B12 (zeige NDUFB3 Antikörper) from lysosomes into the cytosol.

  2. 13-cis (zeige CISH Antikörper)-retinoic acid induces ABCD2 expression in human monocytes/macrophages.

  3. ABCD2 has a role, but not a strong one, in risk of early recurrent events after transient ischemic attack

  4. results show that although patients with ABCD2 score greater than 4 were more likely to develop recurrent TIA/CVA in short term, those with lesser score still harbour a considerable risk for TIA/CVA

  5. The transcriptional activity of the ABCD2 promoter was strongly increased by ectopic expression of beta-catenin (zeige CTNNB1 Antikörper) and TCF-4 (zeige TCF4 Antikörper).

  6. LXRalpha (zeige NR1H3 Antikörper) is a negative modulator of Abcd2, acting through a novel regulatory mechanism involving overlapping SREBP and LXRalpha (zeige NR1H3 Antikörper) binding sites

  7. Testosterone metabolites increased expression of ABCD2 mRNA in fibroblasts from X-linked adrenoleukodystrophy patients.

  8. These findings are of particular importance for the attempt of pharmacological induction of ABCD2 as a possible therapeutic approach in X-linked adrenoleukodystrophy.

  9. LDRP (ABCD2) interacts with both farnesylated wild-type and farnesylation-deficient mutant PEX19 (zeige PEX19 Antikörper). This interaction is mediated by amino acids 1-218 of ALDRP.

  10. ALDRP interacts with PMP70 (zeige ABCD3 Antikörper). This interaction occurs via the ALDRP C-terminus [374-740] and the PMP70 (zeige ABCD3 Antikörper) C-terminus [338-659]. This interaction was demonstrated using human PMP70 (zeige ABCD3 Antikörper) and mouse ALDRP.

Mouse (Murine) ATP-Binding Cassette, Sub-Family D (ALD), Member 2 (Abcd2) Interaktionspartner

  1. ABCD1 (zeige ABCD1 Antikörper) and its homolog ABCD2 exist mainly as homotetramers in the peroxisomal membrane

  2. Abcd2 is a strong modifier of the metabolic impairments in peritoneal macrophages of ABCD1 (zeige ABCD1 Antikörper)-deficient mice

  3. The absence of ABCD2 altered expression of gene clusters associated with lipid metabolism, including PPARalpha (zeige PPARA Antikörper) signaling.

  4. ABCD2 is a sterol regulatory element binding protein (zeige CNBP Antikörper) target gene that is highly abundant in fat and opposes the accumulation of dietary lipids generally absent from the triglyceride storage pool within adipose tissue.

  5. Evidence against the adrenoleukodystrophy-related gene acting as a modifier of X-adrenoleukodystrophy.

  6. LXRalpha (zeige NR1H3 Antikörper) is a negative modulator of Abcd2, acting through a novel regulatory mechanism involving overlapping SREBP and LXRalpha (zeige NR1H3 Antikörper) binding sites

  7. Abcd1 (zeige ABCD1 Antikörper) and Abcd2 gene silencing sensitizes astrocytes for inflammation and may have a role in X-adrenoleukodystrophy

  8. ABCD2 plays a role in th degradation of long-chain saturated and omega9-monounsaturated fatty acids and in the synthesis of docosahexanoic acid.

Abcd2 Antigen-Profil

Beschreibung des Gens

The protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the ALD subfamily, which is involved in peroxisomal import of fatty acids and/or fatty acyl-CoAs in the organelle. All known peroxisomal ABC transporters are half transporters which require a partner half transporter molecule to form a functional homodimeric or heterodimeric transporter. The function of this peroxisomal membrane protein is unknown\; however this protein is speculated to function as a dimerization partner of ABCD1 and/or other peroxisomal ABC transporters. Mutations in this gene have been observed in patients with adrenoleukodystrophy, a severe demyelinating disease. This gene has been identified as a candidate for a modifier gene, accounting for the extreme variation among adrenoleukodystrophy phenotypes. This gene is also a candidate for a complement group of Zellweger syndrome, a genetically heterogeneous disorder of peroxisomal biogenesis.

Alternative names and synonyms associated with Abcd2

  • ATP-binding cassette, sub-family D (ALD), member 2 (ABCD2) Antikörper
  • ABC transporter D family protein (abcD2) Antikörper
  • ATP-binding cassette, sub-family D (ALD), member 2 (abcd2) Antikörper
  • ATP-binding cassette, sub-family D (ALD), member 2 (Abcd2) Antikörper
  • ATP-binding cassette, subfamily D (ALD), member 2 (Abcd2) Antikörper
  • ABC39 Antikörper
  • ALDL1 Antikörper
  • ALDR Antikörper
  • ALDRP Antikörper
  • DDBDRAFT_0214891 Antikörper
  • DDBDRAFT_0219834 Antikörper
  • DDB_0214891 Antikörper
  • DDB_0219834 Antikörper
  • hALDR Antikörper

Bezeichner auf Proteinebene für Abcd2

ATP-binding cassette, sub-family D, member 2 , ATP-binding cassette, sub-family D (ALD), member 2 , ATP-binding cassette sub-family D member 2 , ATP-binding cassette sub-family D member 2-like , adrenoleukodystrophy-like 1 , adrenoleukodystrophy-related protein , adrenoleukodystrophy related

GENE ID SPEZIES
466952 Pan troglodytes
477643 Canis lupus familiaris
526436 Bos taurus
8629134 Dictyostelium discoideum AX4
100413459 Callithrix jacchus
100520309 Sus scrofa
417694 Gallus gallus
697556 Macaca mulatta
100019263 Monodelphis domestica
100433322 Pongo abelii
100549247 Meleagris gallopavo
100556516 Anolis carolinensis
100583742 Nomascus leucogenys
100640478 Amphimedon queenslandica
225 Homo sapiens
26874 Mus musculus
84356 Rattus norvegicus
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