Thymidylate Synthetase Proteine (TYMS)

Bezeichnung:
Thymidylate Synthetase Proteine (TYMS)
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Synonyme:
ECK2823, FN1, HST422, JW2795, TMS, TS
alle Proteine anzeigen Gen GeneID UniProt
Maus TYMS TYMS 22171 P07607
TYMS 7298 P04818
TYMS 29261 P45352

Weitere Synonyme anzeigen

Thymidylate Synthetase Proteine (TYMS) nach Spezies

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Am meisten referenzierte Thymidylate Synthetase Proteine

  1. Human TYMS Protein expressed in Escherichia coli (E. coli) - ABIN666924 : Chiu, Lai, Hsia, Yang, Lai, Wu, Ma, Yeh, Ho, Lu, Wood, Chung: Aloe-emodin induces cell death through S-phase arrest and caspase-dependent pathways in human tongue squamous cancer SCC-4 cells. in Anticancer research 2009 (PubMed)
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Weitere Proteine zu Thymidylate Synthetase Interaktionspartnern

Mouse (Murine) Thymidylate Synthetase (TYMS) Interaktionspartner

  1. Possible interaction routes between hydrophobic residues of the mouse thymidylate synthase protein N-terminal segment and the active site are also discussed

  2. SHMT1 (zeige SHMT1 Proteine) and TYMS localization to the nucleus is essential to prevent uracil accumulation in DNA

  3. Synergistic activation of the TATA-less thymidylate synthase promoter by the Ets transcription factor (zeige ELF2 Proteine) GABP and Sp1 (zeige SP1 Proteine).

  4. downregulation of expression results in block of cell cycle expression when influenced by Fe65 (zeige APBB1 Proteine)

  5. posttranslationally-modified thymidylate synthase is associated with cell resistance to 5-fluoro-dUrd

Human Thymidylate Synthetase (TYMS) Interaktionspartner

  1. The Thymidylate synthase (TS)-ZEB1 association was confirmed in clinical specimens from lung tumours and in a genetic mouse model of pancreatic cancer with ZEB1 deletion. Interestingly, TS itself appeared to have a regulatory role in epithelial-to-mesenchymal in cancer cells, as TS knockdown could directly reduce the EMT (zeige ITK Proteine) phenotype, the migratory ability of cells, the expression of stem-like markers, and chemoresistance.

  2. Study of genetic risk of prevalent hrHPV infections in Nigerian women found significant associations with SNPs on ribosomal protein gene S19 (RPS19 (zeige RPS19 Proteine)) and Thymidylate Synthase gene (TYMS), in an allelic model. This risk remained significant, after adjusting for age, body mass index, smoking, age at menarche, age at sexual debut, lifetime total number of sexual partners and the total number of pregnancies.

  3. High thymidylate synthetase expression is associated with chemoresistance in glioblastoma multiforme.

  4. A PCR technique was used for genotyping TYMS-TSER.

  5. Data suggest that TYMS exhibits a ligand-binding site in dimer interface, suggesting that cavity in dimer interface serves as an allosteric site to regulate conformational switching between active and inactive states of the enzyme.

  6. Combined expression analyses of hENT1, TS, and DPD (zeige DPYD Proteine) may predict long-term outcomes in patients with borderline resectable pancreatic cancer after neoadjuvant chemoradiotherapy

  7. In pancreatic neuroendocrine neoplasms, biochemical response (p = 0.005) and high dihydropyrimidine-dehydrogenase (zeige DPYD Proteine) expression (p = 0.018) were predictive markers of response to 5-FU-based chemotherapy. Thymidylate-Synthase deficiency was an independent risk factor for shorter progression-free survival.

  8. Data suggest the potential association of methylenetetrahydrofolate reductase (MTHFR (zeige MTHFR Proteine)), thymidylate synthase (TS) and TS enhancer region (TSER) polymorphisms with recurrent implantation failure (RIF) risk in Korean patients.

  9. PCB (zeige PC Proteine) followed by PB was effective and safe in our study group. This regimen was associated with acceptable toxicity and with prolonged OS. In our cohort both Ki67 (zeige MKI67 Proteine) and TS expression were important prognostic biomarkers.

  10. this meta-analysis suggested that thymidylate synthase enhancer region (TSER) variation in the TYMS gene was not related to susceptibility to develop pediatric acute lymphoblastic leukemia

Thymidylate Synthetase (TYMS) Protein Überblick

Protein Überblick

Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase.

Alternative names and synonyms associated with Thymidylate Synthetase (TYMS)

  • thymidylate synthetase (TYMS)
  • thymidylate synthetase (thyA)
  • thymidylate synthetase (td)
  • thymidylate synthetase (thyE)
  • thymidylate synthetase (LOC100037674)
  • thymidylate synthetase (tyms)
  • thymidylate synthetase (LOC100222097)
  • thymidylate synthase (Tyms)
  • thymidylate synthetase (Tyms)
  • ECK2823 Protein
  • FN1 Protein
  • HST422 Protein
  • JW2795 Protein
  • TMS Protein
  • TS Protein

Bezeichner auf Proteinebene für Thymidylate Synthetase Proteine (TYMS)

fibronectin 1 , thymidylate synthase , thymidylate synthetase , thymidylate synthase-like , Tsase , TSase , TS

GENE ID SPEZIES
740018 Pan troglodytes
949035 Escherichia coli str. K-12 substr. MG1655
4156567 Aeromonas phage 25
4405636 Enterobacteria phage RB32
7803492 Enterobacteria phage RB51
9415915 Ralstonia solanacearum CFBP2957
9431860 Xenorhabdus nematophila ATCC 19061
9487079 Staphylococcus aureus
9732454 Dickeya dadantii 3937
100037674 Ovis aries
100125228 Xenopus laevis
100222097 Taeniopygia guttata
100459110 Pongo abelii
697580 Macaca mulatta
7803982 Enterobacteria phage RB14
7992740 Methylobacterium extorquens AM1
8195292 Methylobacterium extorquens DM4
8833316 Xenorhabdus bovienii SS-2004
8913233 Erwinia amylovora CFBP1430
9404045 Herbaspirillum seropedicae SmR1
9408872 Ralstonia solanacearum PSI07
22171 Mus musculus
7298 Homo sapiens
29261 Rattus norvegicus
507631 Bos taurus
100627209 Sus scrofa
421060 Gallus gallus
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