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Thymidylate Synthetase Proteine (TYMS)

Thymidylate Synthetase Proteine (TYMS)
Auf finden Sie aktuell 18 Thymidylate Synthetase (TYMS) Proteine von 7 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Thymidylate Synthetase Antikörper (224) und Thymidylate Synthetase Kits (16) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 265 Thymidylate Synthetase Produkte verfügbar.
ECK2823, FN1, HST422, JW2795, TMS, TS
alle Proteine anzeigen Gen GeneID UniProt
Maus TYMS TYMS 22171 P07607
TYMS 7298 P04818
TYMS 29261 P45352

Weitere Synonyme anzeigen

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Am meisten referenzierte Thymidylate Synthetase Proteine

  1. Human TYMS Protein expressed in Escherichia coli (E. coli) - ABIN666924 : Chiu, Lai, Hsia, Yang, Lai, Wu, Ma, Yeh, Ho, Lu, Wood, Chung: Aloe-emodin induces cell death through S-phase arrest and caspase-dependent pathways in human tongue squamous cancer SCC-4 cells. in Anticancer research 2009 (PubMed)
    Zeige alle 2 Referenzen für ABIN666924

Weitere Proteine zu Thymidylate Synthetase Interaktionspartnern

Mouse (Murine) Thymidylate Synthetase (TYMS) Interaktionspartner

  1. Possible interaction routes between hydrophobic residues of the mouse thymidylate synthase protein N-terminal segment and the active site are also discussed

  2. SHMT1 (zeige SHMT1 Proteine) and TYMS localization to the nucleus is essential to prevent uracil accumulation in DNA

  3. Synergistic activation of the TATA-less thymidylate synthase promoter by the Ets transcription factor (zeige ELF2 Proteine) GABP and Sp1 (zeige SP1 Proteine).

  4. downregulation of expression results in block of cell cycle expression when influenced by Fe65 (zeige APBB1 Proteine)

  5. posttranslationally-modified thymidylate synthase is associated with cell resistance to 5-fluoro-dUrd

Human Thymidylate Synthetase (TYMS) Interaktionspartner

  1. this meta-analysis suggested that thymidylate synthase enhancer region (TSER) variation in the TYMS gene was not related to susceptibility to develop pediatric acute lymphoblastic leukemia

  2. These findings suggested that the down-regulation of AKT (zeige AKT1 Proteine)-mediated TS expression by salinomycin enhanced the cisplatin-induced cytotoxicity in nonsmall cell lung cancer cells.

  3. results indicate significant correlation between the Lauren and Goseki histopathological classifications of gastric cancer and TS expression in tumor cells, and suggest that high TS expression may be a positive prognostic marker with regard to DFS (zeige FST Proteine) in patients with gastric cancer without involvement of regional lymph nodes who underwent radical surgical treatment and were not treated with preoperative chemotherapy.

  4. High titers of both TYMS and PDLIM1 (zeige PDLIM1 Proteine) serum autoantibodies were significantly more prevalent in breast cancer cases than in controls.

  5. Studies suggest that dietary folate intake and gender may modify the associations between 5,10-methylenetetrahydrofolate reductase (MTHFR (zeige MTHFR Proteine)) and thymidylate synthase (TS) polymorphisms and adult leukemia risk.

  6. The expressions of TYMS, TUBB3 (zeige TUBB3 Proteine) and STMN1 (zeige STMN1 Proteine) were significantly associated with the clinicopathological characteristics of age, gender and family history of gastric cancer, but not with differentiation, growth patterns, metastasis and TNM (zeige ODZ1 Proteine) staging in patients with gastric cancer.

  7. High expression of TYMS is associated with Colorectal cancer.

  8. This study identified a novel single repeat in the TYMS gene which might have an impact on the expression of this gene, which needs to be confirmed by functional studies.

  9. There were no other associations between single -nucleotide polymorphisms and the efficacy of MTX (zeige MTX1 Proteine) treatment. CONCLUSIONS: The MTHFR (zeige MTHFR Proteine) 677CC and GGH (zeige GGH Proteine) 401TT and CT genotypes were associated with a reduction in the number of MTX (zeige MTX1 Proteine)-related adverse events.

  10. Our findings emphasize the pivotal relevance of RNAi as an effective tool for increasing the therapeutic efficacy of PMX (zeige PRRX1 Proteine), a cornerstone in the treatment regimens of Malignant mesothelioma thereby, raising the possibility for the development of a novel therapeutic strategy, combination therapy of TS-shRNA and PMX (zeige PRRX1 Proteine), that can surpass many of the currently applied, but less effective, therapeutic regimens against lethal MPM.

Thymidylate Synthetase (TYMS) Protein Überblick

Protein Überblick

Thymidylate synthase catalyzes the methylation of deoxyuridylate to deoxythymidylate using 5,10-methylenetetrahydrofolate (methylene-THF) as a cofactor. This function maintains the dTMP (thymidine-5-prime monophosphate) pool critical for DNA replication and repair. The enzyme has been of interest as a target for cancer chemotherapeutic agents. It is considered to be the primary site of action for 5-fluorouracil, 5-fluoro-2-prime-deoxyuridine, and some folate analogs. Expression of this gene and that of a naturally occuring antisense transcript rTSalpha (GeneID:55556) vary inversely when cell-growth progresses from late-log to plateau phase.

Alternative names and synonyms associated with Thymidylate Synthetase (TYMS)

  • thymidylate synthetase (TYMS)
  • thymidylate synthetase (thyA)
  • thymidylate synthetase (td)
  • thymidylate synthetase (thyE)
  • thymidylate synthetase (LOC100037674)
  • thymidylate synthetase (tyms)
  • thymidylate synthetase (LOC100222097)
  • thymidylate synthase (Tyms)
  • thymidylate synthetase (Tyms)
  • ECK2823 Protein
  • FN1 Protein
  • HST422 Protein
  • JW2795 Protein
  • TMS Protein
  • TS Protein

Bezeichner auf Proteinebene für Thymidylate Synthetase Proteine (TYMS)

fibronectin 1 , thymidylate synthase , thymidylate synthetase , thymidylate synthase-like , Tsase , TSase , TS

740018 Pan troglodytes
949035 Escherichia coli str. K-12 substr. MG1655
4156567 Aeromonas phage 25
4405636 Enterobacteria phage RB32
7803492 Enterobacteria phage RB51
9415915 Ralstonia solanacearum CFBP2957
9431860 Xenorhabdus nematophila ATCC 19061
9487079 Staphylococcus aureus
9732454 Dickeya dadantii 3937
100037674 Ovis aries
100125228 Xenopus laevis
100222097 Taeniopygia guttata
100459110 Pongo abelii
697580 Macaca mulatta
7803982 Enterobacteria phage RB14
7992740 Methylobacterium extorquens AM1
8195292 Methylobacterium extorquens DM4
8833316 Xenorhabdus bovienii SS-2004
8913233 Erwinia amylovora CFBP1430
9404045 Herbaspirillum seropedicae SmR1
9408872 Ralstonia solanacearum PSI07
22171 Mus musculus
7298 Homo sapiens
29261 Rattus norvegicus
507631 Bos taurus
100627209 Sus scrofa
421060 Gallus gallus
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