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Based on the results of clinical trials, we conclude that Ribonucleotide reductase (RR) enzymes (RR1 (zeige RRM1 ELISA Kits) and RR2)inhibitors are viable treatment options, either as a monotherapy or as a combination in cancer chemotherapy. With the recent advances made in cancer biology, further development of RR inhibitors with improved efficacy and reduced toxicity is possible for treatment of variety of cancers.
Here we designed UC-rich and CU-rich 10-nt sequences for engagement of both RRM2 and RRM3 and demonstrated that the TIA-1 (zeige TIA1 ELISA Kits) RRM23 construct preferentially binds the UC-rich RNA ligand. Together our data support a specific mode of TIA-1 (zeige TIA1 ELISA Kits) RRM23 interaction with target oligonucleotides consistent with the role of TIA-1 (zeige TIA1 ELISA Kits) in binding RNA to regulate gene expression
These data suggest that VASH2 reduces the chemosensitivity to gemcitabine in pancreatic cancer cells via JUN (zeige JUN ELISA Kits)-dependent transactivation of RRM2.
HPV31 regulates RRM2 levels through expression of E7 and activation of the ATR (zeige ANTXR1 ELISA Kits)-Chk1 (zeige CHEK1 ELISA Kits)-E2F1 (zeige E2F1 ELISA Kits) DNA damage response, which is essential to combat replication stress upon entry into S-phase.
To the best of our knowledge, this is the first study that investigated the relationship of RRM1 (zeige RRM1 ELISA Kits) and RRM2 gene polymorphisms and Coronary artery disease (CAD (zeige CAD ELISA Kits)).
The SCYL1- BP1 (zeige GORAB ELISA Kits) affects the cell cycle through increasing steady state levels of Cyclin F (zeige CCNF ELISA Kits) and RRM2 proteins, thus constituting a dual regulatory circuit.
A significant association has been found between RRM2 rs6759180 (located in the 5'UTR (zeige UTS2R ELISA Kits), 10126436G>A) and the risk for developing non-small cell lung cancer.
Data show that ribonucleotide reductase M2 (RRM2) is associated with increased nuclear factor kappa B (NF-kappaB (zeige NFKB1 ELISA Kits)) activity.
our findings establish a signaling role for RRM2 in gastric cancer cells and identify that the RRM2/AKT (zeige AKT1 ELISA Kits)/NF-kappaB (zeige NFKB1 ELISA Kits) signaling pathway is essential for tumor invasiveness in gastric cancer cells
HBV exploits the Chk1 (zeige CHEK1 ELISA Kits)-E2F1 (zeige E2F1 ELISA Kits) axis of the DNA damage response pathway to induce R2 expression in a cell cycle-independent manner.
This work reveals that binding of RRM1 (zeige RRM1 ELISA Kits) to RRM2 is essential for mammalian cells and provides the first loss-of-function model of the ribonucleotide reductase complex for genetic studies.
mice carrying extra alleles of the RNR (zeige REN1 ELISA Kits) regulatory subunit RRM2 (Rrm2(TG)) present supraphysiological RNR (zeige REN1 ELISA Kits) activity and reduced chromosomal breakage at fragile sites
analysis of transgenic overexpression of ribonucleotide reductase Rrm1 (zeige RRM1 ELISA Kits) and Rrm2 improves cardiac performance
Cinobufotalin significantly inhibits the growth of the xenografts of endometrial carcinoma Ishikawa in nude mice by inhibiting RRM2 expression.
Data suggest that RRM2 may be an important effector of progesterone signaling to induce cell proliferation and decidualization in uterus.
illegitimate recombination initiated by c-Myc (zeige MYC ELISA Kits)
Adrenergic stimulation of brown adipocytes elevates ribonucleotide reductase subunit R2 in the proliferative stage of adipocyte development; mediating pathways include cAMP/PKA cascades, Src (zeige SRC ELISA Kits) and Erk (zeige EPHB2 ELISA Kits) Map Kinases.
S Phase-specific transcription of the mouse ribonucleotide reductase R2 gene requires both a proximal repressive E2F (zeige E2F1 ELISA Kits)-binding site and an upstream promoter activating region
Chk1 is required for DNA replication at least through regulating RNR2 gene transcription.
results indicate that the affinity of the RNR (zeige REN1 ELISA Kits) R2 proteins for binding metals is determined by the nature of one specific residue in the vicinity of the dimetal site, namely the one that carries the tyrosyl radical in class Ia and Ib R2 proteins
This gene encodes one of two non-identical subunits for ribonucleotide reductase. This reductase catalyzes the formation of deoxyribonucleotides from ribonucleotides. Synthesis of the encoded protein (M2) is regulated in a cell-cycle dependent fashion. Transcription from this gene can initiate from alternative promoters, which results in two isoforms that differ in the lengths of their N-termini. Related pseudogenes have been identified on chromosomes 1 and X.
ribonucleoside-diphosphate reductase subunit M2
, ribonucleotide reductase M2 polypeptide
, ribonucleotide reductase small chain
, ribonucleotide reductase small subunit
, ribonucleoside-diphosphate reductase M2 chain
, Ribonucleotide reductase 2
, reductase M2 polypeptide variant 1
, reductase M2 polypeptide variant 2
, reductase M2 polypeptide variant 3a
, reductase M2 polypeptide variant 3b
, reductase M2 polypeptide variant 3c
, reductase M2 polypeptide variant 3d
, ribonucleotide reductase protein r2 class I