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Data demonstrate that TNF-alpha (zeige TNF ELISA Kits) expression is primarily dependent on both the chymotrypsin-and the trypsin-like activities of X, Y, Z subunits (PSMB5 (zeige PSMB5 ELISA Kits), PSMB6, PSMB7 (zeige PSMB7 ELISA Kits)) of the proteasome.
results indicate ZAG (zeige AZGP1 ELISA Kits) as a possible predictive marker of Gleason grade. The inverse association between grade and tissue expression with a rising serum protein level is similar to that seen with prostate-specific antigen. In addition, the results for both ZAG (zeige AZGP1 ELISA Kits) and PSMB-6 highlight the challenges in trying to associate the protein levels in serum with tissue expression
Data indicate that treatment-emergent resistance to single-agent bortezomib was independent of variants in the proteasome genes PSMB1 (zeige PSMB1 ELISA Kits), PSMB5 (zeige PSMB5 ELISA Kits), PSMB6, PSMB8 (zeige PSMB8 ELISA Kits), PSMB9 (zeige PSMB9 ELISA Kits), and PSMB10 (zeige PSMB10 ELISA Kits).
The proteasome is a multicatalytic proteinase complex with a highly ordered ring-shaped 20S core structure. The core structure is composed of 4 rings of 28 non-identical subunits\; 2 rings are composed of 7 alpha subunits and 2 rings are composed of 7 beta subunits. Proteasomes are distributed throughout eukaryotic cells at a high concentration and cleave peptides in an ATP/ubiquitin-dependent process in a non-lysosomal pathway. The encoded protein is a member of the proteasome B-type family, also known as the T1B family, and is a 20S core beta subunit in the proteasome. Alternatively spliced transcript variants encoding multiple isoforms have been observed for this gene.
low molecular mass protein 19
, macropain delta chain
, multicatalytic endopeptidase complex delta chain
, proteasome delta chain
, proteasome subunit Y
, proteasome subunit beta type-6
, subunit 2
, proteasome beta 6 subunit
, proteasome chain 5
, PSY large multifunctional protease Y
, proteasome catalytic subunit 1
, proteasome subunit delta