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Methionine Adenosyltransferase I, alpha Proteine (MAT1A)

Methionine Adenosyltransferase I, alpha Proteine (MAT1A)
Auf finden Sie aktuell 13 Methionine Adenosyltransferase I, alpha (MAT1A) Proteine von 6 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Methionine Adenosyltransferase I, alpha Antikörper (52) und Methionine Adenosyltransferase I, alpha Kits (26) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 100 Methionine Adenosyltransferase I, alpha Produkte verfügbar.
AdoMet, AI046368, Ams, E130115E11Rik, HMAT1, HUMMAT1H, MAT, MAT1, MAT1H, MATA1, P36, PEA-15, PED, SADE, SAMS, SAMS1, SAS, wu:fi35e01, zgc:55442
alle Proteine anzeigen Gen GeneID UniProt
MAT1A 17420 P51949
MAT1A 4143 Q00266
MAT1A 25331 P13444

Weitere Synonyme anzeigen

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Am meisten referenzierte Methionine Adenosyltransferase I, alpha Proteine

  1. Human MAT1A Protein expressed in Escherichia coli (E. coli) - ABIN667767 : Ding, Mouzaki, You, Laird, Mato, Lu, Rountree: CD133+ liver cancer stem cells from methionine adenosyl transferase 1A-deficient mice demonstrate resistance to transforming growth factor (TGF)-beta-induced apoptosis. in Hepatology (Baltimore, Md.) 2009 (PubMed)
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Weitere Proteine zu Methionine Adenosyltransferase I, alpha Interaktionspartnern

Mouse (Murine) Methionine Adenosyltransferase I, alpha (MAT1A) Interaktionspartner

  1. MAT1A is required for normal VLDL assembly and plasma lipid homeostasis in mice. Impaired VLDL synthesis, mainly due to SAMe deficiency, contributes to NAFLD development in MAT1A-KO mice.

  2. Deletion of the TFIIH kinase subunit Mat1 in mouse fibroblasts leads to dramatically reduced RNA polymerase II Ser5 phosphorylation.

  3. DUSP1 (zeige DUSP1 Proteine) mRNA and protein levels are lower in Mat1a knockout livers and fall rapidly in cultured hepatocytes.

  4. investigated the function of the Cdk7 (zeige CDK7 Proteine).cyclin (zeige PCNA Proteine) H.Mat1 complex in murine embryonic stem (ES) cells and preimplantation embryos to determine whether it regulates the unique cell cycle structure and transcriptional network of pluripotent cells

  5. Spontaneous oxidative stress and liver tumors in mice lacking methionine adenosyltransferase 1A

  6. MAT1A knockout hepatocytes have more baseline DNA synthesis but no mitogenic response to hepatocyte growth factor (zeige HGF Proteine). MAT1A-produced SAMe has a major role in ERK (zeige EPHB2 Proteine) signaling & cyclin D1 (zeige CCND1 Proteine) regulation during liver regeneration & mitogenic signal response.

  7. Mat1a(-/-) mice have expansion of liver stem cells as they age. These cells have increased expression of several oncogenes and are tumorigenic in vivo.

  8. C/EBPbeta (zeige CEBPB Proteine) plays an important role in epigenetic regulation of the mature hepatic gene MAT1A

  9. By 1 month of age, genomic instability increases in livers of Mat1a knockout mice, possibly due to reduced APEX1 (zeige APEX1 Proteine) levels

  10. CD133(+)CD45(-) oval cells isolated from premalignant 16-month-old Mat1a(-/-) mice demonstrated significant resistance to transforming growth factor-beta-induced apoptosis compared to CD133(-) cells.

Human Methionine Adenosyltransferase I, alpha (MAT1A) Interaktionspartner

  1. S-adenosyl-L-methionine (zeige AS3MT Proteine) diminishes hepatitis C virus expression by altering MAT1A/2A signaling in hepatocytes.

  2. Data suggest the role of the phospholipase C epsilon-Protein kinase D (zeige PRKD1 Proteine)-PEA15 (zeige PEA15 Proteine) protein-ribosomal S6 kinase (zeige RPS6KB1 Proteine)-IkappaB-NF-kappa B (zeige NFKB1 Proteine) pathway in facilitating inflammation and inflammation-associated carcinogenesis in the colon.

  3. Integrin alpha5beta1 and p53 (zeige TP53 Proteine) convergent pathways in the control of anti-apoptotic proteins PEA-15 (zeige PEA15 Proteine) and survivin (zeige BIRC5 Proteine) in high-grade glioma.

  4. High PED expression is associated with esophageal carcinoma.

  5. The nuclear translocation of SApErk1/ 2 apart from PEA-15 (zeige PEA15 Proteine) as an important mechanism to reverse senescence phenotype.

  6. Latent HCMV infection of CD34 (zeige CD34 Proteine) + cells protects cells from FAS (zeige FAS Proteine)-mediated apoptosis through the cellular IL-10 (zeige IL10 Proteine)/PEA-15 (zeige PEA15 Proteine) pathway.

  7. New therapeutic targets based around PEA-15 (zeige PEA15 Proteine) and its associated interactions are now being uncovered and could provide novel avenues for treatment strategies in multiple diseases.

  8. PED/PEA-15 overexpression is sufficient to block hydrogen peroxide-induced apoptosis in Ins-1E cells through a PLD-1 mediated mechanism

  9. Omi/HtrA2 (zeige HTRA2 Proteine) overexpression promotes hepatocellular carcinoma cell apoptosis and the ped/pea-15 expression level causes this difference of the Omi/HtrA2 (zeige HTRA2 Proteine) pro-apoptotic marker in the various hepatocellular carcinoma cell lines

  10. Results suggest that neurochemical adaptations of brain FADD (zeige FADD Proteine), as well as its interaction with PEA-15 (zeige PEA15 Proteine), could play a major role to counteract the known activation of the mitochondrial apoptotic pathway in major depression

Methionine Adenosyltransferase I, alpha (MAT1A) Protein Überblick

Protein Überblick

This gene encodes a death effector domain-containing protein, which is a major phosphoprotein in astrocytes, and an endogenous substrate for protein kinase C. Studies using knockout mice suggest that this protein may protect astrocytes from TNF-induced apoptosis. This protein is also overexpressed in type 2 diabetes mellitus, where it may contribute to insulin resistance in glucose uptake.

Alternative names and synonyms associated with Methionine Adenosyltransferase I, alpha (MAT1A)

  • menage a trois 1 (Mnat1)
  • methionine adenosyltransferase I, alpha (mat1a)
  • methionine adenosyltransferase I, alpha (MAT1A)
  • methionine adenosyltransferase I, alpha (Mat1a)
  • phosphoprotein enriched in astrocytes 15 (PEA15)
  • AdoMet Protein
  • AI046368 Protein
  • Ams Protein
  • E130115E11Rik Protein
  • HMAT1 Protein
  • HUMMAT1H Protein
  • MAT Protein
  • MAT1 Protein
  • MAT1H Protein
  • MATA1 Protein
  • P36 Protein
  • PEA-15 Protein
  • PED Protein
  • SADE Protein
  • SAMS Protein
  • SAMS1 Protein
  • SAS Protein
  • wu:fi35e01 Protein
  • zgc:55442 Protein

Bezeichner auf Proteinebene für MAT1A

CDK-activating kinase assembly factor MAT1 , CDK7/cyclin H assembly factor , CDK7/cyclin-H assembly factor , RING finger protein MAT1 , p35 , S-adenosylmethionine synthase isoform type-1 , MAT 1 , MAT-I/III , S-adenosylmethionine synthetase isoform type-1 , adoMet synthase 1 , adoMet synthetase 1 , methionine adenosyltransferase 1 , methionine adenosyltransferase I/III , S - adenosylmethionine synthetase , 15 kDa phosphoprotein enriched in astrocytes , Phosphoprotein enriched in astrocytes, 15kD , astrocytic phosphoprotein PEA-15 , homolog of mouse MAT-1 oncogene , phosphoprotein enriched in diabetes

17420 Mus musculus
334195 Danio rerio
423628 Gallus gallus
4143 Homo sapiens
608788 Canis lupus familiaris
100156922 Sus scrofa
541078 Bos taurus
11720 Mus musculus
25331 Rattus norvegicus
8682 Homo sapiens
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