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interplay between MATalpha1, c-Myc (zeige MYC Proteine), and Maf (zeige MAF Proteine) proteins, and their deregulation during chronic cholestasis may facilitate cholangiocarcinoma oncogenesis
MAT1A is required for normal VLDL assembly and plasma lipid homeostasis in mice. Impaired VLDL synthesis, mainly due to SAMe deficiency, contributes to NAFLD development in MAT1A-KO mice.
Deletion of the TFIIH kinase subunit Mat1 in mouse fibroblasts leads to dramatically reduced RNA polymerase II Ser5 phosphorylation.
DUSP1 (zeige DUSP1 Proteine) mRNA and protein levels are lower in Mat1a knockout livers and fall rapidly in cultured hepatocytes.
investigated the function of the Cdk7 (zeige CDK7 Proteine).cyclin (zeige PCNA Proteine) H.Mat1 complex in murine embryonic stem (ES) cells and preimplantation embryos to determine whether it regulates the unique cell cycle structure and transcriptional network of pluripotent cells
This study demonstrates a requirement for MAT1 in the operation of PGC-1 coactivators that control cell metabolism.
study found that Mat1 and Cdk7 (zeige CDK7 Proteine) levels are undetectable in adipose tissues in vivo and downregulated during adipogenesis
Spontaneous oxidative stress and liver tumors in mice lacking methionine adenosyltransferase 1A
MAT1A knockout hepatocytes have more baseline DNA synthesis but no mitogenic response to hepatocyte growth factor (zeige HGF Proteine). MAT1A-produced SAMe has a major role in ERK (zeige EPHB2 Proteine) signaling & cyclin D1 (zeige CCND1 Proteine) regulation during liver regeneration & mitogenic signal response.
Mat1a(-/-) mice have expansion of liver stem cells as they age. These cells have increased expression of several oncogenes and are tumorigenic in vivo.
PEA15 (zeige PEA15 Proteine) expression was not significantly correlated with ovarian cancer antineoplastic drug resistance.
Of the 22 single nucleotide polymorphisms studied, the rs8193 polymorphism lying in the micro-RNA binding site of 3'-UTR of CD44 (zeige CD44 Proteine) was significantly (P=.0270) associated with RT-induced adverse skin reactions. Generalized multifactor dimensionality reduction analysis showed significant (P=.0107) gene-gene interactions between MAT1A and CD44 (zeige CD44 Proteine).
A compound mutation of the methionine adenosyltransferase 1A (MAT1A) gene, c.345delA and c.529C>T, was identified in the patient, and His father and mother were found to be heterozygous for the c.345delA mutation and c.529C>T mutation, respectively.
S-adenosyl-L-methionine (zeige AS3MT Proteine) diminishes hepatitis C virus expression by altering MAT1A/2A signaling in hepatocytes.
Data suggest the role of the phospholipase C epsilon-Protein kinase D (zeige PRKD1 Proteine)-PEA15 (zeige PEA15 Proteine) protein-ribosomal S6 kinase (zeige RPS6KB1 Proteine)-IkappaB-NF-kappa B (zeige NFKB1 Proteine) pathway in facilitating inflammation and inflammation-associated carcinogenesis in the colon.
Integrin alpha5beta1 and p53 (zeige TP53 Proteine) convergent pathways in the control of anti-apoptotic proteins PEA-15 (zeige PEA15 Proteine) and survivin (zeige BIRC5 Proteine) in high-grade glioma.
High PED expression is associated with esophageal carcinoma.
The nuclear translocation of SApErk1/ 2 apart from PEA-15 (zeige PEA15 Proteine) as an important mechanism to reverse senescence phenotype.
Latent HCMV infection of CD34 (zeige CD34 Proteine) + cells protects cells from FAS (zeige FAS Proteine)-mediated apoptosis through the cellular IL-10 (zeige IL10 Proteine)/PEA-15 (zeige PEA15 Proteine) pathway.
This gene catalyzes a two-step reaction that involves the transfer of the adenosyl moiety of ATP to methionine to form S-adenosylmethionine and tripolyphosphate, which is subsequently cleaved to PPi and Pi. S-adenosylmethionine is the source of methyl groups for most biological methylations. The encoded protein is found as a homotetramer (MAT I) or a homodimer (MAT III) whereas a third form, MAT II (gamma), is encoded by the MAT2A gene. Mutations in this gene are associated with methionine adenosyltransferase deficiency.
, S-adenosylmethionine synthase isoform type-1
, S-adenosylmethionine synthetase isoform type-1
, adoMet synthase 1
, adoMet synthetase 1
, methionine adenosyltransferase 1
, methionine adenosyltransferase I/III
, CDK-activating kinase assembly factor MAT1
, CDK7/cyclin H assembly factor
, CDK7/cyclin-H assembly factor
, RING finger protein MAT1
, S - adenosylmethionine synthetase