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A comparative study of various species of DHFR shows that zDHFR has comparable thermodynamic stability with human counterpart and thus proved to be a good in vitro model system for structure- function relationship studies.
Dihydrofolate reductase is required for the development of heart and outflow tract in zebrafish.
The abundance of dihydrofolate reductase was statistically significantly increased in rheumatoid arthritis (RA)-patient biopsies compared with controls and correlated with the administered dosage of methotrexate (MTX (zeige MTX1 ELISA Kits)), the most frequently prescribed immunosuppressive drug for RA.
The present study demonstrated that ADAR1 (zeige ADAR ELISA Kits) positively regulates the expression of DHFR by editing the miR (zeige MLXIP ELISA Kits)-25-3p and miR (zeige MLXIP ELISA Kits)-125a-3p binding sites in the 3'-UTR (zeige UTS2R ELISA Kits) of DHFR, enhancing cellular proliferation and resistance to methotrexate in MCF-7 cells.
In conclusion, the finding suggests that folate nutrition and 19bp del-DHFR [Dihydrofolate reductase] variation may interact to modify adenomatous polyp [colorectal cancer] risk.
the highest expression of GGH (zeige GGH ELISA Kits) and EGFR (zeige EGFR ELISA Kits) was noted in the left-sided colon; the highest expression of DHFR, FPGS (zeige FPGS ELISA Kits), TOP1 (zeige TOP1 ELISA Kits) and ERCC1 (zeige ERCC1 ELISA Kits) was noted in the rectosigmoid, whereas TYMP (zeige TYMP ELISA Kits) expression was approximately equivalent in the right-sided colon and rectum
Overexpression of miR (zeige MLXIP ELISA Kits)-192 inhibited cellular proliferation by binding DHFR. miR (zeige MLXIP ELISA Kits)-192 decreased cellular anchoring via the repression of ITGAV (zeige ITGAV ELISA Kits), ITGB1 (zeige ITGB1 ELISA Kits), ITGB3 (zeige ITGB3 ELISA Kits), and CD47 (zeige CD47 ELISA Kits)
Data suggest that DHFR exhibits intrinsic activity kinetics that are temperature-independent; additional mass (i.e., incorporation of H, C, and N isotopes) has no effect on intrinsic activity kinetics or protein conformation/stability of DHFR.
patients homozygous for the G allele of rs1053129 in the DHFR gene were more likely to have a metastasis (45%, P= 0.005), and the methylenetetetrahydrofolate reductase (MTHFR (zeige MTHFR ELISA Kits)) 677C allele was associated with higher degree of liver toxicity
the association between cognitive outcomes with the 19-bp deletion DHFR polymorphism, folate status, and their interaction with high or normal plasma folate
S-nitrosylation of DHFR at cysteine 7 by eNOS (zeige NOS3 ELISA Kits)-derived NO is crucial for DHFR stability.
genetic association studies in cohort of healthy young adults in Ireland: Data suggest that a 19 bp deletion/insertion polymorphism within intron 1 of DHFR (rs70991108) is not associated with folate nutritional status in the population studied.
The study reports arrested hematopoiesis and vascular relaxation defects in mice with a point mutation, Thr136Ala substitution in Dhfr.
demonstrate that dihydrofolate reductase activity is also a feature of the mitochondria in both rat and mouse but this is not due to a second enzyme
Robust and processive unfolding/degradation of some substrates with very stable protein domains, including mDHFR and titin (zeige TTN ELISA Kits)(I27) .
protects endothelial nitric oxide synthase (zeige NOS3 ELISA Kits) from uncoupling in tetrahydrobiopterin deficiency
Dhfr has a role in folate regulation of axonal regeneration in the rodent central nervous system through DNA methylation (zeige HELLS ELISA Kits)
E2F (zeige E2F1 ELISA Kits)-responsive dihydrofolate reductase promoter regulates the balance between acetylation and methylation of histone H3 (zeige HIST3H3 ELISA Kits) lysine 9
translocation of the DHFR domain was greatly impaired when it was separated from the signal-anchor sequence
mechanical stability of mouse dihydrofolate reductase is dominated by local interactions within the protein structure
Crystal structures are reported for NADPH (zeige FDXR ELISA Kits) ternary complexes with PY1011 and mouse DHFR (mDHFR), refined to 2.2 A resolution.
Hydrogen peroxide down regulates expression in response to angiotensin Ii and underlies endothelial nitric oxide synthase (zeige NOS3 ELISA Kits) dysfunction.
Dihydrofolate reductase converts dihydrofolate into tetrahydrofolate, a methyl group shuttle required for the de novo synthesis of purines, thymidylic acid, and certain amino acids. While the functional dihydrofolate reductase gene has been mapped to chromosome 5, multiple intronless processed pseudogenes or dihydrofolate reductase-like genes have been identified on separate chromosomes. Dihydrofolate reductase deficiency has been linked to megaloblastic anemia.
, dihydrofolate reductase DhfR
, Dihydrofolate reductase
, Dihydrofolate reductase 1 (active)