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Human TUBB3 Protein expressed in HEK-293 Cells - ABIN2734576
Qu, Dwyer, Shao, Yang, Huang, Liu: Direct binding of TUBB3 with DCC couples netrin-1 signaling to intracellular microtubule dynamics in axon outgrowth and guidance. in Journal of cell science 2013
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By linkage and sequencing analyses, we identified the mutation c.784C>T (p.R262C) in TUBB3 gene in six members of a Turkish family with congenital fibrosis of the extraocular muscles.
High TUBB3 expression is associated with Melanoma.
these results identify a broad spectrum of cancers that can at least sporadically express TUBB3. Testing of TUBB3 in cancer types eligible for taxane-based therapies could be helpful to identify patients who might best benefit from this treatment.
TUBB3 overexpression is linked to an aggressive subtype of urinary bladder cancers, which is characterized by increased genetic instability, p53 (zeige TP53 Proteine) alterations, and rapid cell proliferation.
The central findings of our study are that TSA (zeige PRDX2 Proteine) and VPA affect the expression of neuronal lineage genes in an rMSCs culture. After exposure to TSA (zeige PRDX2 Proteine) or VPA, the expression of early neuronal gene decreases but equally the expression of mature neuron genes increases
a positive correlation was observed between Snail (zeige SNAI1 Proteine) presence and TUBB3 upregulation in tested adenocarcinoma cell lines.
This elucidates a hitherto unknown role for this microtubule protein and provides insight into correlations between high betaIII-tubulin expression and poor patient outcome in this disease
TUBB3 involvement in breast cancer cells apoptosis
The expressions of TYMS (zeige TYMS Proteine), TUBB3 and STMN1 (zeige STMN1 Proteine) were significantly associated with the clinicopathological characteristics of age, gender and family history of gastric cancer, but not with differentiation, growth patterns, metastasis and TNM (zeige ODZ1 Proteine) staging in patients with gastric cancer.
It findings reveal that expression of relatively low levels of TUBB3 in mitotic cells can be detrimental for their cytokinesis and underscore the importance of CIT-K (zeige CIT Proteine) in counteracting this event.
Here, we report that dissociation of UNC5C (zeige Unc5c Proteine) and polymerized TUBB3, the highly dynamic beta-tubulin (zeige TUBB Proteine) isoform in neurons, is essential for netrin-1 (zeige NTN1 Proteine)/UNC5C (zeige Unc5c Proteine)-promoted axon repulsion. These results not only provide a working model of direct modulation of MTs (zeige NEU2 Proteine) by guidance cues in growth cone navigation but also help us to understand molecular mechanisms underlying developmental brain disorders associated with TUBB3 mutations.
Tubb3 could be regulated by both Akt (zeige AKT1 Proteine) and Erk (zeige EPHB2 Proteine) pathways.
Results suggest that down syndrome cell adhesion molecule (zeige DSCAM Proteine) collaborates with deleted in colorectal cancer (zeige DCC Proteine) to regulate microtubule dynamics via direct binding to dynamic TUBB3 in Netrin-1 (zeige NTN1 Proteine)-induced axon branching.
Differentiation-mediated activation of JunD results in enhanced TUBB4a expression in P19 embryonal carcinoma cells.
determined the alpha-synuclein-binding domain of beta-III tubulin and demonstrated that a short fragment containing this domain can suppress alpha-synuclein accumulation in the primary cultured cells
Study shows the critical and specific role of Tubb3 on the stereotyped morphological changes and polarization processes that are required for initiating radial migration to the cortical plate.
this study reports that TUBB3, the most dynamic beta-tubulin (zeige TUBB Proteine) isoform in neurons, directly interacts with the netrin receptor DCC (zeige DCC Proteine), and that netrin-1 (zeige NTN1 Proteine) induces this interaction in primary neurons.
Access to a running wheel for 48h induced plastic changes in the expression of astrocyte beta-tubulin (zeige TUBB Proteine) (III). Expression was increased in the cerebellum while much smaller increases were observed in the other motor regions.
interaction between alpha-syn and beta-III tubulin (zeige TUBB Proteine) plays an important role in neuronal alpha-syn accumulation in an multiple system atrophy mouse model.
This gene encodes a class III member of the beta tubulin protein family. Beta tubulins are one of two core protein families (alpha and beta tubulins) that heterodimerize and assemble to form microtubules. This protein is primarily expressed in neurons and may be involved in neurogenesis and axon guidance and maintenance. Mutations in this gene are the cause of congenital fibrosis of the extraocular muscles type 3. Alternate splicing results in multiple transcript variants. A pseudogene of this gene is found on chromosome 6.
, beta-tubulin 3
, tubulin, beta 3
, tubulin beta-3 chain
, beta3 tubulin
, beta-tubulin class-IV
, tubulin, beta, 3
, tubulin, beta, 4
, class III beta-tubulin
, tubulin beta-4 chain
, tubulin beta-III
, neuron-specific class III beta-tubulin
, tubulin beta-4A chain
, tubulin, beta 4