Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Alle Spezies anzeigen
Weitere Synonyme anzeigen
Select your species
polarity-induced spatiotemporal control of Rok and Pkn (zeige PKN1 ELISA Kits) is important for unequal cortical expansion, ensuring correct cleavage furrow positioning and the establishment of physical asymmetry.
Loss of DRok function in tendon cells results in mis (zeige AMH ELISA Kits)-orientation of tendon cell extensions and abnormal accumulation of Thrombospondin and betaPS-integrin, which may cause abnormal myotendinous (zeige TNC ELISA Kits) junction formation and muscle morphogenesis.
model in which Rok-induced phosphorylation of residues within the basic region mediates the activation of FHOD1 (zeige FHOD1 ELISA Kits) homolog Knittrig in controlling macrophage migration
Atonal and EGFR (zeige EGFR ELISA Kits) signalling orchestrate rok- and Drak-dependent adherens junction remodelling during ommatidia morphogenesis.
The structure of Shrm (zeige SHROOM3 ELISA Kits) domain 2 (SD2), which mediates the interaction with Rock and is required for Shrm (zeige SHROOM3 ELISA Kits) function, is reported.
Data show that that Drak broadly promotes proper morphogenesis of epithelial tissues during development, and Drak activity is largely redundant with that of the Drosophila ROCK orthologue, Rok.
CD44 (zeige CD44 ELISA Kits) interaction with p115RhoGEF (zeige ARHGEF1 ELISA Kits) and ROK plays a pivotal role in promoting Gab-1 phosphorylation leading to Gab-1.PI 3 (zeige PI3 ELISA Kits)-kinase membrane localization, AKT (zeige AKT1 ELISA Kits) signaling, and cytokine (M-CSF (zeige CSF1R ELISA Kits)) production during HA-mediated breast cancer progression
Drok and Drosophila Lim (zeige ZYX ELISA Kits)-kinase interact in the developing nervous system
DRok is required for tissue morphogenesis in diverse compartments of the egg chamber during oogenesis
activation of RhoA/ROCK and PI3K/Akt plays a pivotal role in leptin signaling, leading to the development of VSMC hypertrophy through a mechanism involving altered actin dynamics
we define how ROCK/LIMK (zeige LIMK1 ELISA Kits) pathway regulates mast cell development and functions
Dexamethasone up-regulates ROCK1/2 activity promoting migration, invasion and metastasis of melanoma cells.
mDia induces circumferential actin filaments around the edge of the synaptic cleft, which contract the presynaptic terminals in a ROCK-dependent manner.
SNRK (zeige SNRK ELISA Kits) in cardiomyocytes is responsible for maintaining cardiac metabolic homeostasis, which is mediated in part by ROCK, and alteration of this homeostasis influences cardiac function in the adult heart.
we uncovered cell state plasticity and adhesion dynamics regulated by Ror2 (zeige ROR2 ELISA Kits), which influenced Ras Homology Family Member A (zeige CXCL14 ELISA Kits) (RhoA (zeige RHOA ELISA Kits)) and Rho-Associated Coiled-Coil Kinase 1 (ROCK1) activity downstream of Dishevelled-2 (Dvl2 (zeige DVL2 ELISA Kits)).
Data indicate that oxidative stress in diabetes causes a decrease in miR (zeige MLXIP ELISA Kits)-133a expression leading to an increase in RhoA (zeige RHOA ELISA Kits)/Rho kinase (zeige ROCK2 ELISA Kits) pathway and muscle contraction.
that reduction of ROCK1 diminishes amyloid-beta levels by enhancing Amyloid beta-Protein Precursor protein degradation
ANXA1 (zeige ANXA1 ELISA Kits) restores Abeta42-induced blood brain barrier disruption through inhibition of RhoA (zeige RHOA ELISA Kits)-ROCK signaling pathway
the cross-talk between canonical and non-canonical signaling pathways of Wnt3A (zeige WNT3A ELISA Kits), which induces GSK-3beta (zeige GSK3b ELISA Kits) phosphorylation and beta-catenin (zeige CTNNB1 ELISA Kits) accumulation through RhoA (zeige RHOA ELISA Kits) and ROCK activation.
Inhibition of ROCK1 largely blocked Endothelial-to-mesenchymal transition and the increase in endothelial permeability under this high-glucose condition, but overexpression of ROCK1 induced these changes.
ROCK activation phosphorylated Rac1b (zeige RAC3 ELISA Kits) at Ser71 and increased reactive oxygen species (ROS (zeige ROS1 ELISA Kits)) levels by facilitating the interaction between Rac1b (zeige RAC3 ELISA Kits) and cytochrome c (zeige CYCS ELISA Kits). Conversely, ROCK inactivation abolished their interaction, concomitant with ROS (zeige ROS1 ELISA Kits) reduction.
OB-Rb (zeige LEPR ELISA Kits), RhoA (zeige RHOA ELISA Kits)/ROCK, PI3K (zeige PIK3CA ELISA Kits)/AKT (zeige AKT1 ELISA Kits), JAK (zeige JAK3 ELISA Kits)/STAT (zeige STAT1 ELISA Kits) pathways and NF-kB activation are involved in leptin (zeige LEP ELISA Kits)-induced upA (zeige PRAP1 ELISA Kits) expression.
data suggests that ROCK1 may serve as a potential therapeutic target to enhance current treatment regimens for pancreatic cancer
Genetic variant in ROCK1 gene is associated with progression of prostate cancer.
Results showed that ROCK1 gene rs2271255 (Lys222Glu), rs35996865, and ROCK2 (zeige ROCK2 ELISA Kits) gene rs726843, rs2290156, rs10178332, rs35768389 (Asp601Val) polymorphisms were significantly associated with respiratory distress syndrome (RDS (zeige PRPH2 ELISA Kits)), and that they could be a risk factor for development of neonatal RDS (zeige PRPH2 ELISA Kits).
Despite sharing the catalytic domain with ROCK2 (zeige ROCK2 ELISA Kits), ROCK1 appears to be the dominant kinase essential for junctional integrity and contractile tension at epithelial ZA.
RhoA (zeige RHOA ELISA Kits)/ROCK and Raf-1 (zeige RAF1 ELISA Kits)/CK2 (zeige CSNK2A1 ELISA Kits) pathway are responsible for TNF-alpha (zeige TNF ELISA Kits)-mediated endothelial cytotoxicity via regulation of the vimentin (zeige VIM ELISA Kits) cytoskeleton.
High ROCK1 expression is associated with Clear cell renal cell carcinoma.
Results indicate that ROCK1 and ROCK2 (zeige ROCK2 ELISA Kits) may exert different biological functions during the regulation of compaction and in ensuring development of porcine preimplantation embryos to the blastocyst stage.
It is highly possible that Rho-kinase plays an important role in the pathogenesis of in-stent restenosis. Rho-kinase is not involved in endothelial regeneration after vascular injury.
results suggest that the ROCK/MLC/actomyosin as well as ROCK/LIMK (zeige LIMK1 ELISA Kits)/cofilin (zeige CFL1 ELISA Kits) pathways regulate meiotic spindle migration and cytokinesis during bovine oocyte maturation.
In airway smooth muscle, muscle contraction involves the translocation of ROCK1 from non-caveolar to caveolar regions.
p38 (zeige MAPK14 ELISA Kits) phosphorylation and MMP13 (zeige MMP13 ELISA Kits) expression are regulated by Rho/ROCK activation, and support the potential novel pathway that Rho/ROCK is in the upper part of the mechanical stress-induced matrix degeneration cascade in cartilage.
The RhoA (zeige RHOA ELISA Kits)/ROCK signaling pathway is an important negative regulator of vascular calcification.
caveolar and cholesterol integrity are indispensable for the proper functionality of the H(1) and 5-HT(2A) receptors through their Rho/ROCK signaling.
A functional contribution of PI3K, Rho, and ROCK to both the autocrine mechanism of ATP release and ATP-mediated angiogenic activation of vasa (zeige DDX4 ELISA Kits) vasorum endothelial cells, is reported.
This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity.
Rho-associated coiled coil containing protein kinase 1
, rho-associated protein kinase 1
, Rho-associated, coiled-coil containing protein kinase 1
, Rho-associated kinase
, RhoA kinase
, drosophila rho-associated kinase
, rho kinase
, Rho-associated coiled-coil forming kinase 1
, p160 ROCK-1
, rho-associated, coiled-coil-containing protein kinase 1
, rho-associated, coiled-coil-containing protein kinase I
, Rho-associated kinase beta
, liver regeneration-related protein LRRG199
, p150 RhoA-binding kinase ROK beta
, Rho kinase
, renal carcinoma antigen NY-REN-35
, cAMP-dependent protein kinase ROCK-I
, corneal epithelial Rho-associated-Ser/Thr kinase 1
, Rho-kinase beta
, Rho-associated protein kinase 1
, rho-associated coiled-coil domain-containing protein kinase 1