anti-ROCK1 (ROCK1) Antikörper

Bezeichnung:
anti-rho-Associated, Coiled-Coil Containing Protein Kinase 1 Antikörper (ROCK1)
Auf www.antikoerper-online.de finden Sie aktuell 152 rho-Associated, Coiled-Coil Containing Protein Kinase 1 (ROCK1) Antikörper von 28 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen ROCK1 Proteine (9) und ROCK1 Kits (4) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 170 ROCK1 Produkte verfügbar.
Synonyme:
1110055K06Rik, CG9774, Dmel\\CG9774, DRhk, drok, LOC100229794, p160ROCK, Rhk, RhoK, Rock, ROCK-1, ROCK-I, ROCK1, Rok, ROKalpha/beta

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anti-Mouse (Murine) ROCK1 Antikörper:

anti-Rat (Rattus) ROCK1 Antikörper:

anti-Human ROCK1 Antikörper:

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Am meisten referenzierte anti-ROCK1 Antikörper

  1. Human Monoclonal ROCK1 Primary Antibody für IF, WB - ABIN968386 : Ishizaki, Maekawa, Fujisawa, Okawa, Iwamatsu, Fujita, Watanabe, Saito, Kakizuka, Morii, Narumiya: The small GTP-binding protein Rho binds to and activates a 160 kDa Ser/Thr protein kinase homologous to myotonic dystrophy kinase. in The EMBO journal 1996 (PubMed)
    Zeige alle 5 Referenzen für 968386

  2. Dog (Canine) Monoclonal ROCK1 Primary Antibody für ICC, IF - ABIN252549 : Zhao, Miller, Pfeiffer, Buras, Stahl: Anoxia and reoxygenation of human endothelial cells decrease ceramide glucosyltransferase expression and activates caspases. in FASEB journal : official publication of the Federation of American Societies for Experimental Biology 2003 (PubMed)
    Zeige alle 4 Referenzen für 252549

  3. Human Polyclonal ROCK1 Primary Antibody für ICC, IF - ABIN152055 : Chang, Xie, Shah, Schneider, Entman, Wei, Schwartz: Activation of Rho-associated coiled-coil protein kinase 1 (ROCK-1) by caspase-3 cleavage plays an essential role in cardiac myocyte apoptosis. in Proceedings of the National Academy of Sciences of the United States of America 2006 (PubMed)
    Zeige alle 3 Referenzen für 152055

  4. Human Monoclonal ROCK1 Primary Antibody für IF, ELISA - ABIN562671 : Gong, Fang, Peng, Liu, Du: Integration of virtual screening with high-throughput screening for the identification of novel Rho-kinase I inhibitors. in Journal of biotechnology 2010 (PubMed)
    Zeige alle 2 Referenzen für 562671

  5. Human Polyclonal ROCK1 Primary Antibody für IF (p), IHC (p) - ABIN707771 : Wang, Zhang, Wang, Zhang, Mao, Zhuang, Tang, Luo, Zhou, Zhang: Vascular endothelial growth factor stimulates endothelial differentiation from mesenchymal stem cells via Rho/myocardin-related transcription factor--a signaling pathway. in The international journal of biochemistry & cell biology 2013 (PubMed)
    Zeige alle 2 Referenzen für 707771

  6. Human Monoclonal ROCK1 Primary Antibody für ELISA, WB - ABIN969563 : Kroll, Epting, Kern, Dietz, Feng, Hammes, Wieland, Augustin: Inhibition of Rho-dependent kinases ROCK I/II activates VEGF-driven retinal neovascularization and sprouting angiogenesis. in American journal of physiology. Heart and circulatory physiology 2009 (PubMed)
    Zeige alle 2 Referenzen für 969563

  7. Human Monoclonal ROCK1 Primary Antibody für WB - ABIN223244 : Dasgupta, Argaiz, Mercado, Maul, Garza, Enriquez, Abdel-Monem, Prakasam, Andreeff, Thiagarajan: Platelet senescence and phosphatidylserine exposure. in Transfusion 2010 (PubMed)

Weitere Antikörper gegen ROCK1 Interaktionspartner

Fruit Fly (Drosophila melanogaster) rho-Associated, Coiled-Coil Containing Protein Kinase 1 (ROCK1) Interaktionspartner

  1. Loss of DRok function in tendon cells results in mis (zeige AMH Antikörper)-orientation of tendon cell extensions and abnormal accumulation of Thrombospondin and betaPS-integrin, which may cause abnormal myotendinous (zeige TNC Antikörper) junction formation and muscle morphogenesis.

  2. model in which Rok-induced phosphorylation of residues within the basic region mediates the activation of FHOD1 (zeige FHOD1 Antikörper) homolog Knittrig in controlling macrophage migration

  3. Atonal and EGFR (zeige EGFR Antikörper) signalling orchestrate rok- and Drak-dependent adherens junction remodelling during ommatidia morphogenesis.

  4. The structure of Shrm (zeige SHROOM3 Antikörper) domain 2 (SD2), which mediates the interaction with Rock and is required for Shrm (zeige SHROOM3 Antikörper) function, is reported.

  5. Data show that that Drak broadly promotes proper morphogenesis of epithelial tissues during development, and Drak activity is largely redundant with that of the Drosophila ROCK orthologue, Rok.

  6. CD44 (zeige CD44 Antikörper) interaction with p115RhoGEF (zeige ARHGEF1 Antikörper) and ROK plays a pivotal role in promoting Gab-1 (zeige GAB1 Antikörper) phosphorylation leading to Gab-1 (zeige GAB1 Antikörper).PI 3 (zeige PI3 Antikörper)-kinase membrane localization, AKT (zeige AKT1 Antikörper) signaling, and cytokine (M-CSF (zeige CSF1R Antikörper)) production during HA-mediated breast cancer progression

  7. Drok and Drosophila Lim (zeige ZYX Antikörper)-kinase interact in the developing nervous system

  8. DRok is required for tissue morphogenesis in diverse compartments of the egg chamber during oogenesis

  9. activation of RhoA/ROCK and PI3K/Akt plays a pivotal role in leptin signaling, leading to the development of VSMC hypertrophy through a mechanism involving altered actin dynamics

  10. In parallel to regulation of crb RNA and protein, Rho1 activity also signals through Rho-kinase (Rok) to induce apical constriction and cell shape change during invagination of salivary gland.

Mouse (Murine) rho-Associated, Coiled-Coil Containing Protein Kinase 1 (ROCK1) Interaktionspartner

  1. that reduction of ROCK1 diminishes amyloid-beta levels by enhancing Amyloid beta-Protein Precursor protein degradation

  2. ANXA1 (zeige ANXA1 Antikörper) restores Abeta42-induced blood brain barrier disruption through inhibition of RhoA (zeige RHOA Antikörper)-ROCK signaling pathway

  3. the cross-talk between canonical and non-canonical signaling pathways of Wnt3A (zeige WNT3A Antikörper), which induces GSK-3beta (zeige GSK3b Antikörper) phosphorylation and beta-catenin (zeige CTNNB1 Antikörper) accumulation through RhoA (zeige RHOA Antikörper) and ROCK activation.

  4. Inhibition of ROCK1 largely blocked Endothelial-to-mesenchymal transition and the increase in endothelial permeability under this high-glucose condition, but overexpression of ROCK1 induced these changes.

  5. While the loss of either Rock1 or Rock2 (zeige ROCK2 Antikörper) had no negative impact on tumorigenesis in mouse models of non-small cell lung cancer and melanoma, loss of both blocked tumor formation, as no tumors arise in which both Rock1 and Rock2 (zeige ROCK2 Antikörper) have been genetically deleted.

  6. Fyn (zeige FYN Antikörper) mediates high glucose-induced actin cytoskeleton remodeling of podocytes via promoting ROCK activation and paxillin (zeige PXN Antikörper) phosphorylation

  7. YQFM ameliorates the OGD-induced brain microvascular endothelial cell barrier disruption associated with the NF-kappaB/p65 and ROCK1/MLC signaling pathways.

  8. Extracellular vesicle-encapsulated caspase-3 (zeige CASP3 Antikörper) was largely responsible for the alveolar macrophage activation via the ROCK1 pathway.

  9. In experimental autoimmune encephalomyelitis (EAE), ROCK activity was also increased in serum, spleen, brain and spinal cord. Neuron injury with scratch and TNF-alpha (zeige TNF Antikörper) stimulation induced the up-regulation of ROCK activity.

  10. indicates that the up-regulation of ROCK1 activity in RhoA (zeige RHOA Antikörper)-deleted macrophages and macrophage phenotype/polarity are dependent on non-apoptotic Caspase-3 (zeige CASP3 Antikörper)

Human rho-Associated, Coiled-Coil Containing Protein Kinase 1 (ROCK1) Interaktionspartner

  1. Despite sharing the catalytic domain with ROCK2 (zeige ROCK2 Antikörper), ROCK1 appears to be the dominant kinase essential for junctional integrity and contractile tension at epithelial ZA.

  2. RhoA (zeige RHOA Antikörper)/ROCK and Raf-1 (zeige RAF1 Antikörper)/CK2 (zeige CSNK2A1 Antikörper) pathway are responsible for TNF-alpha (zeige TNF Antikörper)-mediated endothelial cytotoxicity via regulation of the vimentin (zeige VIM Antikörper) cytoskeleton.

  3. High ROCK1 expression is associated with Clear cell renal cell carcinoma (zeige MOK Antikörper).

  4. Studies showed that ROCK isoforms, ROCK1 and ROCK2 (zeige ROCK2 Antikörper), have been found in various types of neuron-like cell lines and neurons, and function as different regulators in axon outgrowth, neurite retraction, cell survival, autophagy, energy balance, and generation of endogenous beta amyloid. [review]

  5. BCR-ABL-dependent ROCK, but not TK, is involved in CD1d downregulation. We propose that ROCK, which is most likely activated by the DH/PH domain of BCR-ABL, mediates iNKT-cell immune subversion in chronic myeloid leukaemia (CML) patients by downregulating CD1d expression on CML mDCs.

  6. that reduction of ROCK1 diminishes amyloid-beta levels by enhancing Amyloid beta-Protein Precursor protein degradation

  7. Silencing Drp1 (zeige CRMP1 Antikörper) inhibits glioma cells proliferation and invasion by RHOA (zeige RHOA Antikörper)/ ROCK1 pathway.

  8. RhoB and ROCK play a key role in preeclampsia.

  9. We successfully identified a novel pathway via which SIN (zeige EFS Antikörper) exerted antioxidative and renal protective functions, and provided a molecular basis for potential SIN (zeige EFS Antikörper) applications in treating DN vascular disorders.

  10. The results of the present study indicate that miR126 inhibits RCC (zeige XRCC1 Antikörper) cell proliferation, migration and invasion by downregulating ROCK1.

Rabbit rho-Associated, Coiled-Coil Containing Protein Kinase 1 (ROCK1) Interaktionspartner

Pig (Porcine) rho-Associated, Coiled-Coil Containing Protein Kinase 1 (ROCK1) Interaktionspartner

  1. Results indicate that ROCK1 and ROCK2 (zeige ROCK2 Antikörper) may exert different biological functions during the regulation of compaction and in ensuring development of porcine preimplantation embryos to the blastocyst stage.

  2. It is highly possible that Rho-kinase plays an important role in the pathogenesis of in-stent restenosis. Rho-kinase is not involved in endothelial regeneration after vascular injury.

Cow (Bovine) rho-Associated, Coiled-Coil Containing Protein Kinase 1 (ROCK1) Interaktionspartner

  1. results suggest that the ROCK/MLC/actomyosin as well as ROCK/LIMK (zeige LIMK1 Antikörper)/cofilin (zeige CFL1 Antikörper) pathways regulate meiotic spindle migration and cytokinesis during bovine oocyte maturation.

  2. In airway smooth muscle, muscle contraction involves the translocation of ROCK1 from non-caveolar to caveolar regions.

  3. p38 (zeige MAPK14 Antikörper) phosphorylation and MMP13 (zeige MMP13 Antikörper) expression are regulated by Rho/ROCK activation, and support the potential novel pathway that Rho/ROCK is in the upper part of the mechanical stress-induced matrix degeneration cascade in cartilage.

  4. The RhoA (zeige RHOA Antikörper)/ROCK signaling pathway is an important negative regulator of vascular calcification.

  5. caveolar and cholesterol integrity are indispensable for the proper functionality of the H(1) and 5-HT(2A (zeige HTR2A PLURAL_@19334@)) receptors through their Rho/ROCK signaling.

  6. A functional contribution of PI3K, Rho, and ROCK to both the autocrine mechanism of ATP release and ATP-mediated angiogenic activation of vasa (zeige DDX4 Antikörper) vasorum endothelial cells, is reported.

ROCK1 Antigen-Profil

Beschreibung des Gens

This gene encodes a protein serine/threonine kinase that is activated when bound to the GTP-bound form of Rho. The small GTPase Rho regulates formation of focal adhesions and stress fibers of fibroblasts, as well as adhesion and aggregation of platelets and lymphocytes by shuttling between the inactive GDP-bound form and the active GTP-bound form. Rho is also essential in cytokinesis and plays a role in transcriptional activation by serum response factor. This protein, a downstream effector of Rho, phosphorylates and activates LIM kinase, which in turn, phosphorylates cofilin, inhibiting its actin-depolymerizing activity.

Alternative names and synonyms associated with ROCK1

  • Rho-associated, coiled-coil containing protein kinase 1 (ROCK1) Antikörper
  • Rho-associated, coiled-coil containing protein kinase 1 (LOC100229794) Antikörper
  • Rho-kinase (rok) Antikörper
  • Rho-associated coiled-coil containing protein kinase 1 (Rock1) Antikörper
  • Rho-associated, coiled-coil containing protein kinase 1 (rock1) Antikörper
  • 1110055K06Rik Antikörper
  • CG9774 Antikörper
  • Dmel\\CG9774 Antikörper
  • DRhk Antikörper
  • drok Antikörper
  • LOC100229794 Antikörper
  • p160ROCK Antikörper
  • Rhk Antikörper
  • RhoK Antikörper
  • Rock Antikörper
  • ROCK-1 Antikörper
  • ROCK-I Antikörper
  • ROCK1 Antikörper
  • Rok Antikörper
  • ROKalpha/beta Antikörper

Bezeichner auf Proteinebene für ROCK1

Rho-associated coiled coil containing protein kinase 1 , rho-associated protein kinase 1 , Rho-associated, coiled-coil containing protein kinase 1 , CG9774-PA , DRho-kinase , ROCK , Rho-associated kinase , RhoA kinase , drosophila rho-associated kinase , rho kinase , rok-PA , Rho-associated coiled-coil forming kinase 1 , p160 ROCK-1 , p160ROCK , rho-associated, coiled-coil-containing protein kinase 1 , rho-associated, coiled-coil-containing protein kinase I , Rho-associated kinase beta , liver regeneration-related protein LRRG199 , p150 RhoA-binding kinase ROK beta , Rho kinase , p160-ROCK , renal carcinoma antigen NY-REN-35 , HEBM1 , cAMP-dependent protein kinase ROCK-I , cePKA , corneal epithelial Rho-associated-Ser/Thr kinase 1 , Rho-kinase beta , Rho-associated protein kinase 1 , rho-associated coiled-coil domain-containing protein kinase 1

GENE ID SPEZIES
100034056 Equus caballus
100229794 Taeniopygia guttata
43916 Drosophila melanogaster
19877 Mus musculus
81762 Rattus norvegicus
6093 Homo sapiens
480181 Canis lupus familiaris
100009220 Oryctolagus cuniculus
397447 Sus scrofa
785911 Bos taurus
455326 Pan troglodytes
100329779 Danio rerio
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