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Studies indicate that protein phosphatase methylesterase-1 (PME-1) negatively regulates protein phosphatase 2A (PP2A (zeige PPP2R4 Proteine)) activity by highly complex mechanisms.
Data suggest that discovery of more potent protein phosphatase methylesterase-1 (PME-1) inhibitors may be beneficial for the treatment of endometrial cancer.
LCMT1 (zeige LCMT1 Proteine)-PME-1 methylation equilibrium is critical for regulating mitotic spindle size and thereby proper cell division
this study suggests that the tightly linked regulatory loop comprised of the SIK2 (zeige SIK2 Proteine)-PP2A (zeige PPP2R4 Proteine) and CaMKI (zeige CAMK1 Proteine) and PME-1 networks may function in fine-tuning cell proliferation and stress response.
PPME1 could be an attractive therapeutic target for a subset of gastric cancer and lung cancer.
Data indicate that PP2A (zeige PPP2R4 Proteine) holoenzyme biogenesis and activity are controlled by five PP2A (zeige PPP2R4 Proteine) modulators, consisting of alpha4, PTPA (zeige PPP2R4 Proteine), LCMT1 (zeige LCMT1 Proteine), PME-1 and TIPRL1, which serve to prevent promiscuous phosphatase activity until the holoenzyme is completely assembled.
GSK-3beta can inhibit PP2A (zeige PPP2R4 Proteine) by increasing the inhibitory L309-demethylation involving upregulation of PME-1 and inhibition of PPMT1 (zeige LCMT1 Proteine)
Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors.
We propose that stabilization of this inactive, nuclear PP2A (zeige PPP2R4 Proteine) pool is a major in vivo function of PME-1.
Observations identify PME-1 expression as one mechanism by which ERK (zeige EPHB2 Proteine) pathway activity is maintained in cancer cells and suggest an important functional role for PME-1 in the disease progression of human astrocytic gliomas.
protects protein phosphatase 2A from ubiquitin/proteasome degradation
PME-1 plays a critical role in differentiation of neuroblastoma (zeige ARHGEF16 Proteine) cells.
targeted disruption of the PME-1 gene causes perinatal lethality in mice, a phenotype that correlates with a virtually complete loss of the demethylated form of PP2A (zeige PPP2R2B Proteine) in the nervous system and peripheral tissues
This gene encodes a protein phosphatase methylesterase localized to the nucleus. The encoded protein acts on the protein phosphatase-2A catalytic subunit and supports the ERK pathway through dephosphorylation of regulatory proteins. It plays a role in malignant glioma progression. Alternative splicing results in multiple transcript variants.
protein phosphatase methylesterase-1
, protein phosphatase methylesterase 1
, phosphatase methylesterase 1