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Protein Phosphatase Methylesterase 1 Proteine (PPME1)

Bezeichnung:
Protein Phosphatase Methylesterase 1 Proteine (PPME1)
Auf www.antikoerper-online.de finden Sie aktuell 15 Protein Phosphatase Methylesterase 1 (PPME1) Proteine von 5 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Protein Phosphatase Methylesterase 1 Antikörper (60) und Protein Phosphatase Methylesterase 1 Kits (7) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 87 Protein Phosphatase Methylesterase 1 Produkte verfügbar.
Synonyme:
1110069N17Rik, 2700017M01Rik, DDBDRAFT_0204584, DDBDRAFT_0305014, DDB_0204584, DDB_0305014, F28M11.4, fk72d03, PME-1, PME1, PME1MGC133824, RGD1309683, wu:fk72d03, zgc:56239
alle Proteine anzeigen Gen GeneID UniProt
PPME1 51400 Q9Y570
PPME1 72590 Q8BVQ5
PPME1 361613 Q4FZT2

Weitere Synonyme anzeigen

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Am meisten referenzierte Protein Phosphatase Methylesterase 1 Proteine

  1. Human PPME1 Protein expressed in Escherichia coli (E. coli) - ABIN667510 : Gagnon, Hengartner, Desnoyers: The genes pme-1 and pme-2 encode two poly(ADP-ribose) polymerases in Caenorhabditis elegans. in The Biochemical journal 2002 (PubMed)
    Zeige alle 2 Referenzen für ABIN667510

Weitere Proteine zu Protein Phosphatase Methylesterase 1 Interaktionspartnern

Human Protein Phosphatase Methylesterase 1 (PPME1) Interaktionspartner

  1. Data suggest that discovery of more potent protein phosphatase methylesterase-1 (PME-1) inhibitors may be beneficial for the treatment of endometrial cancer.

  2. LCMT1 (zeige LCMT1 Proteine)-PME-1 methylation equilibrium is critical for regulating mitotic spindle size and thereby proper cell division

  3. this study suggests that the tightly linked regulatory loop comprised of the SIK2 (zeige SIK2 Proteine)-PP2A (zeige PPP2R4 Proteine) and CaMKI (zeige CAMK1 Proteine) and PME-1 networks may function in fine-tuning cell proliferation and stress response.

  4. PPME1 could be an attractive therapeutic target for a subset of gastric cancer and lung cancer.

  5. Data indicate that PP2A (zeige PPP2R4 Proteine) holoenzyme biogenesis and activity are controlled by five PP2A (zeige PPP2R4 Proteine) modulators, consisting of alpha4, PTPA (zeige PPP2R4 Proteine), LCMT1 (zeige LCMT1 Proteine), PME-1 and TIPRL1, which serve to prevent promiscuous phosphatase activity until the holoenzyme is completely assembled.

  6. GSK-3beta can inhibit PP2A (zeige PPP2R4 Proteine) by increasing the inhibitory L309-demethylation involving upregulation of PME-1 and inhibition of PPMT1 (zeige LCMT1 Proteine)

  7. Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors.

  8. We propose that stabilization of this inactive, nuclear PP2A (zeige PPP2R4 Proteine) pool is a major in vivo function of PME-1.

  9. Observations identify PME-1 expression as one mechanism by which ERK (zeige EPHB2 Proteine) pathway activity is maintained in cancer cells and suggest an important functional role for PME-1 in the disease progression of human astrocytic gliomas.

Mouse (Murine) Protein Phosphatase Methylesterase 1 (PPME1) Interaktionspartner

  1. protects protein phosphatase 2A from ubiquitin/proteasome degradation

  2. Academic cross-fertilization by public screening yields a remarkable class of protein phosphatase methylesterase-1 inhibitors.

  3. PME-1 plays a critical role in differentiation of neuroblastoma (zeige ARHGEF16 Proteine) cells.

  4. targeted disruption of the PME-1 gene causes perinatal lethality in mice, a phenotype that correlates with a virtually complete loss of the demethylated form of PP2A (zeige PPP2R2B Proteine) in the nervous system and peripheral tissues

Protein Phosphatase Methylesterase 1 (PPME1) Protein Überblick

Protein Überblick

This gene encodes a protein phosphatase methylesterase localized to the nucleus. The encoded protein acts on the protein phosphatase-2A catalytic subunit and supports the ERK pathway through dephosphorylation of regulatory proteins. It plays a role in malignant glioma progression. Alternative splicing results in multiple transcript variants.

Alternative names and synonyms associated with Protein Phosphatase Methylesterase 1 (PPME1)

  • protein phosphatase methylesterase 1 (ppme1)
  • esterase/lipase/thioesterase family protein (AT4G10050)
  • protein phosphatase methylesterase 1 (LOC100358403)
  • protein phosphatase methylesterase 1 (PPME1)
  • protein phosphatase methylesterase 1 (Ppme1)
  • similar to S. cerevisiae PPE1 (YHR075C) mitochondrial ribosome small subunit protein YMS2, which resembles a phosphatase-methylesterase (PPE1)
  • 1110069N17Rik Protein
  • 2700017M01Rik Protein
  • DDBDRAFT_0204584 Protein
  • DDBDRAFT_0305014 Protein
  • DDB_0204584 Protein
  • DDB_0305014 Protein
  • F28M11.4 Protein
  • fk72d03 Protein
  • PME-1 Protein
  • PME1 Protein
  • PME1MGC133824 Protein
  • RGD1309683 Protein
  • wu:fk72d03 Protein
  • zgc:56239 Protein

Bezeichner auf Proteinebene für PPME1

protein phosphatase methylesterase 1 , phosphatase methylesterase 1 , protein phosphatase methylesterase-1 , PME-1 , likely mitochondrial ribosomal protein (YMS2)

GENE ID SPEZIES
335124 Danio rerio
826596 Arabidopsis thaliana
8623168 Dictyostelium discoideum AX4
100195184 Salmo salar
100358403 Oryctolagus cuniculus
446717 Xenopus laevis
419058 Gallus gallus
51400 Homo sapiens
612812 Canis lupus familiaris
535390 Bos taurus
72590 Mus musculus
361613 Rattus norvegicus
100173996 Pongo abelii
3635974 Candida albicans SC5314
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