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Human POMC ELISA Kit für Competition ELISA - ABIN414616
Zapletal, Kraus, Cupi?, Gabrilovac: Differential expression of proopiomelanocortin (POMC) transcriptional variants in human skin cells. in Neuropeptides 2013
We identify the neuronal regulatory region of zebrafish pomca and confirm that it is not homologous to the mammalian enhancers.
Hypothalamic pro-opiomelanocortin and AgRP (zeige AGRP ELISA Kits) neurons are hypophysiotropic, projecting to the pituitary to coordinately regulate multiple pituitary hormones.
cloning and characterization of the pro-opiomelanocortin gene
Zebrafish proopiomelanocortin (zfPOMC) contains the consensus sequences for ACTH, gamma-LPH, beta-MSH and beta-endorphin (beta-END). RT-PCR expression studies indicate that zfPOMC is selectively expressed in nervous tissue and in the pituitary gland.
Pituitary expression of proopiomelanocortin provides a unique marker for pituitary anterior and intermediate lobe morphogenesis.
Data indicate the regulation of energy balance in BMPR1A (zeige BMPR1A ELISA Kits)-mediated appetite regulation in POMC neurons.
POMC and AgRP (zeige AGRP ELISA Kits) neurons receive direct steroid- and frequency-dependent glutamatergic synaptic input from Kiss1 (zeige KISS1 ELISA Kits)(ARC (zeige NOL3 ELISA Kits)) neurons in male mice
Localization of the dopamine receptors of types 1 and 2 on the bodies of POMC-expressing neurons of the arcuate nucleus of the hypothalamus in mice and rats.(
disruption of this hippocampal POMC/MC4R (zeige MC4R ELISA Kits) circuit might contribute to synaptic dysfunction observed in Alzheimer's disease.
The data show that somatic MORs in POMC neurons couple to multiple effectors that have differential sensitivity to desensitization of the receptor.
These findings indicate that the relevance of AgRP (zeige AGRP ELISA Kits) to POMC neuron GABA connectivity depends on the state of AgRP (zeige AGRP ELISA Kits) neuron activity and suggest that different types of transmitter release should be considered when circuit mapping.
these data unmasked a role for mitochondrial fission in leptin (zeige LEP ELISA Kits) sensitivity and glucose sensing of POMC neurons.
it is suggested that the suppression of NeuroD1 (zeige NEUROD1 ELISA Kits) expression and the inhibition of NeuroD1 (zeige NEUROD1 ELISA Kits)/E-box interaction may play an important role in the Gc-mediated negative regulation of Pomc.
To clarify the functional roles of the AKT-mTOR pathway in the hippocampal neurons, we generated conditional knockout mice harboring the deletion of Pten (Pten-cKO) in Proopiomelanocortin-expressing neurons.
Epo (zeige EPO ELISA Kits) regulates hypothalamus POMC expression via STAT3 (zeige STAT3 ELISA Kits) activation.
E2F1 (zeige E2F1 ELISA Kits)-mediated hPOMC transcription is a potential target for suppressing ACTH production in ectopic Cushing's syndrome.
Elevated ACTH secretion is associated with Cushing's syndrome.
a novel p53/POMC/Galphas/SASH1 autoregulatory positive feedback loop is regulated by SASH1 mutations to induce pathological hyperpigmentation phenotype.
Data suggest that alpha-MSH enhances cell adhesion to fibronectin (zeige FN1 ELISA Kits) in primary mixed synoviocytes obtained from osteoarthritis patients; alpha-MSH reduces secretion of cytokines (TNF (zeige TNF ELISA Kits), IL-6 (zeige IL6 ELISA Kits) and IL-8 (zeige IL8 ELISA Kits)) in such synoviocyte cultures.
Data suggest that the first screening step diagnosis for pituitary adenoma was determined based upon immunohistochemical (IHC) scores for Pit-1 (zeige POU1F1 ELISA Kits), SF-1 (zeige NR5A1 ELISA Kits), and ACTH.
The aim of this survey is to evaluate the association of genetic variants of melanocortin-4-receptor (MC4R (zeige MC4R ELISA Kits)), pro-opiomelanocortin (POMC), apolipoprotein E (APOE (zeige APOE ELISA Kits)) and agouti-related protein (AGRP (zeige AGRP ELISA Kits)) with obesity in the North Indian population.
The expression of Pomc mRNA was stimulated in the arcuate nucleus after skin exposure to UVB.
hsa (zeige CD24 ELISA Kits)-miR (zeige MLXIP ELISA Kits)-34a can regulate the CRH (zeige CRH ELISA Kits)/CRHR1 (zeige CRHR1 ELISA Kits)/POMC axis and may influence body mass index.
these common variants in PCSK1 (zeige PCSK1 ELISA Kits) and POMC were not the major cause of obesity in the Thai subjects sampled. However, variants in PCSK1 (zeige PCSK1 ELISA Kits) did affect cholesterol level, LDL-C level, and waist circumference.
ACTH was readily detected at significantly higher levels in regions of ACTH-secreting adenomas and in normal anterior adenohypophysis compared with non-secreting adenoma and neurohypophysis.
The expression of the genes coding for proopiomelanocortin (POMC), proenkephalin (PENK (zeige PENK ELISA Kits)) and prodynorphin (PDYN (zeige PDYN ELISA Kits)) in porcine luteal cells isolated from corpora lutea (CL) collected on days 3-6, 8-10 and 13-16 of the oestrous cycle is reported.
The association has been reported between polymorphisms of the CRH (zeige CRH ELISA Kits) and POMC genes with economic traits in Korean cattle.
Expression of the hepatic endocannabinoid system and proopiomelanocortin was altered by plane of dietary energy prepartum particularly during the first 2-week postpartum.
Significant associations were observed between POMC c.288C>T with start-of-finishing weight (SOF (zeige GJA1 ELISA Kits) WT; P = 0.04), hot carcass weight (HCW; P = 0.02), average fat and grade fat (both P = 0.05), carcass rib-eye area (REA (zeige PHB2 ELISA Kits); P = 0.03) and marbling
The polymorphism of POMC gene is associated with the growth traits of Nanyang cattle.
This gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used\; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described.
, adrenal corticotropic hormone
, adrenocorticotropic hormone
, alpha-melanocyte stimulating hormone
, corticotropin-like intermediary peptide
, melanotropin gamma
, alpha-melanocyte-stimulating hormone
, beta-melanocyte-stimulating hormone
, lipotropin beta
, lipotropin gamma
, melanotropin alpha
, melanotropin beta
, opiomelanocortin prepropeptide
, proopiomelanocortin preproprotein
, proopiomelanocortin (adrenocorticotropin/ beta-lipotropin/ alpha-melanocyte stimulating hormone/ beta-melanocyte stimulating hormone/ beta-endorphin)
, proopiomelanocortin, beta (endorphin, beta)
, proopoimelanocortin, beta (endorphin, beta)
, beta-melanocyte stimulating hormone
, pro-opiomelanocortin a-1
, pro-opiomelanocortin a-2
, pro-opiomelanocortin b-1
, pro-opiomelanocortin b-2