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Human RAF1 Protein expressed in Wheat germ - ABIN1317314
Rodríguez-Muñoz, de la Torre-Madrid, Sánchez-Blázquez, Garzón: NO-released zinc supports the simultaneous binding of Raf-1 and PKC? cysteine-rich domains to HINT1 protein at the mu-opioid receptor. in Antioxidants & redox signaling 2011
cdk10 (zeige CDK10 Proteine) has roles in vertebrate development and a critical function in neurogenesis by modulation of raf1a expression
Our results indicate that Rb-Raf-1 interaction plays an important role in spontaneous hair cell regeneration in zebrafish
Zebrafish embryos with morpholino knockdown of raf1 demonstrated the need for raf1 for the development of normal myocardial structure and function.
analysis of the roles of Raf- and PI3K-signalling pathways in melanoma
Both c-Raf and B-Raf (zeige BRAF Proteine) are required for Ras-induced MEK1 (zeige MAP2K1 Proteine) and p42 (zeige EPB42 Proteine) MAP kinase (zeige MAPK1 Proteine) activation.
RhoA (zeige RHOA Proteine)/ROCK and Raf-1/CK2 (zeige CSNK2A1 Proteine) pathway are responsible for TNF-alpha (zeige TNF Proteine)-mediated endothelial cytotoxicity via regulation of the vimentin (zeige VIM Proteine) cytoskeleton.
Although Raf-1 gene is not mutated, an abnormality of Raf-1 kinase feedback regulation enhances its antiapoptotic function, and Raf-1 can still be a pharmaceutical target to increase chemotherapy or radiotherapy sensitivity in these cancer cells.
ZHX2 (zeige ZHX2 Proteine) expression in renal cell carcinoma (zeige MOK Proteine)
RAF1 plays a critical role in maintaining the transformed phenotype of CRC cells, including those with mutated KRAS.
Zhx2 (zeige ZHX2 Proteine) is a novel regulator of Mup expression; Zhx2 (zeige ZHX2 Proteine) activates as well as represses expression of target genes
This finding suggests that stringent assemblage of Hsp90 (zeige HSP90 Proteine) keeps CRAF kinase equipped for participating in the MAPK (zeige MAPK1 Proteine) pathway. Thus, the role of Hsp90 (zeige HSP90 Proteine) in CRAF maturation and activation acts as a limiting factor to maintain the function of a strong client like CRAF kinase.
Oncogenic NFIA:RAF1 fusion activation of the MAPK (zeige MAPK1 Proteine) pathway is associated with pilocytic astrocytoma.
IGF2BP2 (zeige IGF2BP2 Proteine) as a post-transcriptional regulatory mRNA-binding factor, interfering with Raf-1 degradation by miR (zeige MLXIP Proteine)-195, that contributes to Colorectal carcinogenesis.
Data show that when microRNA miR (zeige MLXIP Proteine)-125b was over-expressed in THP-1 macrophages, the expression of Raf1 proto-oncogene (zeige RAB1A Proteine) serine/threonine protein kinase (RAF1) was reduced to promote the apoptosis of macrophages.
Data show that Griffipavixanthone (GPX (zeige GPX1 Proteine)), a dimeric xanthone isolated from Garcinia esculenta, is a B-RAF (zeige SNRPE Proteine) and C-RAF inhibitor against esophageal cancer cells.
data suggest that G alpha(i3), Shc (zeige SHC1 Proteine), Grb2 (zeige GRB2 Proteine), Ras, and Raf-1 link Src (zeige SRC Proteine) to activation of MAPK (zeige MAPK1 Proteine) and to the AT(2)-dependent increase in eNOS (zeige NOS3 Proteine) expression in PAECs
Mechanistically, BRAF (zeige BRAF Proteine) and RAF1 operate independently to balance MAPK (zeige MAPK1 Proteine) signaling: BRAF (zeige BRAF Proteine) promotes ERK (zeige EPHB2 Proteine) activation, while RAF1 dims stress kinase activation.
Neuroprotective (arylthio)cyclopentenone prostaglandins directly bind to c-Raf protein and protect cells from down-regulation of the c-Raf protein itself, resulting in protection against oxidative stress.
Additional Cyp (zeige PPIG Proteine) genes are disregulated in the absence of Zhx2 (zeige ZHX2 Proteine).
A- and B-Raf ablation in chondrocytes does not alter skeletal development, whereas ablation of C-Raf decreases hypertrophic chondrocyte apoptosis and impairs vascularization of the growth plate. However, ablation of C-Raf does not impair phosphate-induced ERK1/2 phosphorylation in vitro, but leads to rickets by decreasing VEGF protein stability.
We confirmed that Raf1(L613V) knock-in confers a NS-like phenotype, including cardiac hypertrophy. Active RSK3 (zeige RPS6KA2 Proteine) was increased in Raf1(L613V) mice. Constitutive RSK3 (zeige RPS6KA2 Proteine) gene deletion prevented the Raf1(L613V)-dependent concentric growth in width of the cardiac myocyte and attenuated cardiac hypertrophy in female mice.
C-Raf involves in osteoblast survival in response to mechanical stress.
Dual inhibition of c-Raf and soluble epoxide hydrolase (zeige EPHX2 Proteine) by t-CUPM prevents mutant KrasG12D-initiated murine pancreatic carcinoma growth.
Simultaneous inhibition of sEH (zeige EPHX2 Proteine) and c-RAF prevents chronic pancreatitis and murine pancreatic intraepithelial neoplasia in LSL-KrasG(1)(2)D/Pdx-1 (zeige PDX1 Proteine)-Cre mice.
under normal physiological conditions, PTEN suppresses AKT (zeige AKT1 Proteine) activity to maintain activation of the RAF1/ERK (zeige EPHB2 Proteine) signaling pathway, which in turn maintains normal function of the initial segment and therefore, normal sperm maturation.
This gene is the cellular homolog of viral raf gene (v-raf). The encoded protein is a MAP kinase kinase kinase (MAP3K), which functions downstream of the Ras family of membrane associated GTPases to which it binds directly. Once activated, the cellular RAF1 protein can phosphorylate to activate the dual specificity protein kinases MEK1 and MEK2, which in turn phosphorylate to activate the serine/threonine specific protein kinases, ERK1 and ERK2. Activated ERKs are pleiotropic effectors of cell physiology and play an important role in the control of gene expression involved in the cell division cycle, apoptosis, cell differentiation and cell migration. Mutations in this gene are associated with Noonan syndrome 5 and LEOPARD syndrome 2.
, RAF proto-oncogene serine/threonine-protein kinase
, proto-oncogene c-RAF
, raf proto-oncogene serine/threonine protein kinase
, murine leukemia viral (v-raf-1) oncogene homolog 1 (3611-MSV)
, v-raf-1 murine leukemia viral oncogene homolog 1
, murine leukemia viral oncogene homolog
, serine/threonine protein kinase RAF1
, MIL proto-oncogene serine/threonine-protein kinase
, c-mil protein
, murine leukemia viral (v-raf-1) oncogene homolog 1
, RAF proto-oncogene serine/threonine-protein kinase-like
, Craf1 transforming
, murine sarcoma 3611 oncogene 1
, sarcoma 3611 oncogene
, v-raf-1 leukemia viral oncogene 1
, Proto-oncogene c-RAF