anti-Maus p38 Antikörper für Immunoprecipitation

Recommended p38 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
MAP kinase p38 (p38) Antikörper
  • CSBP
  • CSBP1
  • CSBP2
  • CSPB1
  • EXIP
  • Mxi2
  • PRKM14
  • PRKM15
  • RK
  • SAPK2A
  • p38
  • p38ALPHA
  • mitogen-activated protein kinase 14
  • MAPK14
Reaktivität
Human, Maus, Ratte (Rattus)
367
265
262
48
30
29
28
26
26
25
21
21
15
15
12
7
5
3
2
1
1
1
Wirt
Maus
277
93
Klonalität
Monoklonal
Konjugat
Dieser p38 Antikörper ist unkonjugiert
10
10
9
7
7
7
6
5
4
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
1
Applikation
Antibody Array (AA), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blotting (WB)
305
158
152
93
67
55
46
29
28
17
13
10
7
6
6
2
1
1
1
1
1
Optionen
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Bilder

Produktnummer ABIN361680
343,62 €
Zzgl. Versandkosten 20,00 € und MWSt
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN223157 IP IHC WB Rabbit IgG pThr180, pTyr182 Anmelden zum Anzeigen Polyclonal 2
1 ABIN2486131 AA ELISA IHC IP WB Atto 390 Mouse IgG1 Anmelden zum Anzeigen 9F12 1
1 ABIN2486132 AA ELISA IHC IP WB Atto 488 Mouse IgG1 Anmelden zum Anzeigen 9F12 1
1 ABIN2486133 AA ELISA IHC IP WB Atto 565 Mouse IgG1 Anmelden zum Anzeigen 9F12 1
1 ABIN2486134 AA ELISA IHC IP WB Atto 594 Mouse IgG1 Anmelden zum Anzeigen 9F12 1
1 ABIN2486135 AA ELISA IHC IP WB Atto 633 Mouse IgG1 Anmelden zum Anzeigen 9F12 1
1 ABIN2486136 AA ELISA IHC IP WB Atto 655 Mouse IgG1 Anmelden zum Anzeigen 9F12 1
1 ABIN2486137 AA ELISA IHC IP WB Atto 680 Mouse IgG1 Anmelden zum Anzeigen 9F12 1
1 ABIN2486138 AA ELISA IHC IP WB Atto 700 Mouse IgG1 Anmelden zum Anzeigen 9F12 1
1 ABIN2486139 AA ELISA IHC IP WB Alkaline Phosphatase (AP) Mouse IgG1 Anmelden zum Anzeigen 9F12 1
1 ABIN2486140 AA ELISA IHC IP WB APC Mouse IgG1 Anmelden zum Anzeigen 9F12 1
1 ABIN2486141 AA ELISA IHC IP WB Biotin Mouse IgG1 Anmelden zum Anzeigen 9F12 1
1 ABIN2486142 AA ELISA IHC IP WB FITC Mouse IgG1 Anmelden zum Anzeigen 9F12 1
1 ABIN2486143 AA ELISA IHC IP WB HRP Mouse IgG1 Anmelden zum Anzeigen 9F12 1
1 ABIN2486144 AA ELISA IHC IP WB PE-Atto 594 Mouse IgG1 Anmelden zum Anzeigen 9F12 1
1 ABIN2486145 AA ELISA IHC IP WB PerCP Mouse IgG1 Anmelden zum Anzeigen 9F12 1
1 ABIN2486146 AA ELISA IHC IP WB PE Mouse IgG1 Anmelden zum Anzeigen 9F12 1
1 ABIN2486147 AA ELISA IHC IP WB Streptavidin Mouse IgG1 Anmelden zum Anzeigen 9F12 1
1 ABIN361848 ICC IF IP IHC WB Rabbit Anmelden zum Anzeigen Polyclonal 7
1 ABIN410092 ELISA ICC IHC IHC (p) IP WB Mouse IgG1 Anmelden zum Anzeigen 9F12

anti-p38 Antikörper für Immunoprecipitation mit den meisten Publikationen

Ähnliche anti-p38 Antikörper

Applikation / Reaktivität Ratte (Rattus) Maus
Antibody Array (AA) 18 Antikörper 18 Antikörper
BioImaging (BI) 2 Antikörper 2 Antikörper
ELISA 101 Antikörper 90 Antikörper
Flow Cytometry (FACS) 6 Antikörper 7 Antikörper
Immunochromatography (IC) 4 Antikörper
Immunocytochemistry (ICC) 28 Antikörper
Immunofluorescence (IF) 39 Antikörper
Immunofluorescence (Cultured Cells) (IF (cc)) 13 Antikörper
Immunofluorescence (fixed cells) (IF/ICC) 6 Antikörper
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 28 Antikörper
Immunohistochemistry (IHC) 117 Antikörper
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 28 Antikörper
Immunoprecipitation (IP) 84 Antikörper
Intracellular Staining (ICS) 10 Antikörper
Western Blotting (WB) 215 Antikörper

General

Antigen MAP kinase p38 (p38) Antikörper
Reaktivität Human, Maus, Ratte (Rattus)
(367), (265), (262), (48), (30), (29), (28), (26), (26), (25), (21), (21), (15), (15), (12), (7), (5), (3), (2), (1), (1), (1)
Wirt Maus
(277), (93)
Klonalität (Klon)
Monoklonal   ( )
Konjugat Dieser p38 Antikörper ist unkonjugiert
(10), (10), (9), (7), (7), (7), (6), (5), (4), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1)
Applikation Antibody Array (AA), ELISA, Immunohistochemistry (IHC), Immunoprecipitation (IP), Western Blotting (WB)
(305), (158), (152), (93), (67), (55), (46), (29), (28), (17), (13), (10), (7), (6), (6), (2), (1), (1), (1), (1), (1)
Pubmed 8 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-p38 Antikörper

Target Details p38 Anwendungsinformationen Handhabung ProductDetails: References for anti-p38 antibody (ABIN361680) Bilder
Spezifität Detects ~38 kDa.
Reinigung Protein G Purified
Immunogen Full length recombinant protein expressed in E.coli cells
Klon 9F12
Isotyp IgG1

Target Details p38

Produktdetails anti-p38 Antikörper Anwendungsinformationen Handhabung ProductDetails: References for anti-p38 antibody (ABIN361680) Bilder zurück nach oben
Antigen
Andere Bezeichnung p38 MAPK (p38 Antibody Abstract)
Hintergrund The MAPK (mitogen activated protein kinase) comprises a family of ubiquitous praline-directed, proteinserine/ threonine kinases which signal transduction pathways that control intracellular events including acute responses to hormones and major developmental changes in organisms (1). This super family consists of stress activated protein kinases (SAPKs), extracellular signal-regulated kinases (ERKs), and p38 kinases, each of which forms a separate pathway (2). The kinase members that populate each pathway are sequentially activated by phosphorylation. Upon activation, p38 MAPK/SAPK2α translocates into the nucleus where it phosphorylates one or more nuclear substrates, effecting transcriptional changes and other cellular processes involved in cell growth, division, differentiation, inflammation, and death (3). Specifically p38 always acts as a pro-apoptotic factor with its activation leading to the release of cytochrome c from mitochondria and cleavage of caspase 3 and its downstream effector, PARP (4). p38 MAPK is activated by a variety of chemical stress inducers including hydrogen peroxide, heavy metals, anisomycin, sodium salicylate, LPS, and biological stress signals such as tumor necrosis factor, interleukin-1, ionizing and UV irradiation, hyperosmotic stress and chemotherapeutic drugs (5). As a result, p38 alpha has been widely validated as a target for inflammatory disease including rheumatoid arthritis, COPD and psoriasis (6) and has also been implicated in cancer, CNS and diabetes (7).
Gen-ID 1432
NCBI Accession NP_001306
UniProt Q16539
Forschungsgebiet Kinases/Phosphatases
Pathways MAPK Signalweg, Neurotrophin Signalübertragung, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Muscle Cell Differentiation, Hepatitis C, Toll-Like Receptors Cascades, Autophagie, Thromboxane A2 Receptor Signaling

Anwendungsinformationen

Produktdetails anti-p38 Antikörper Target Details p38 Handhabung ProductDetails: References for anti-p38 antibody (ABIN361680) Bilder zurück nach oben
Applikationshinweise
  • WB (1:1000)
  • IHC (1:1000)
  • optimal dilutions for assays should be determined by the user.
Kommentare

Detects ~38kDa protein corresponding to p38α MAPK when loaded with 6 ng of purified p38α by chemiluminescent immunoblot analysis using Goat anti-mouse IgG:HRP as the secondary antibody.

Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-p38 Antikörper Target Details p38 Anwendungsinformationen ProductDetails: References for anti-p38 antibody (ABIN361680) Bilder zurück nach oben
Format Liquid
Konzentration 1 mg/mL
Buffer PBS, 50 % glycerol, 0.09 % sodium azide
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C

ProductDetails: References for anti-p38 antibody (ABIN361680)

Produktdetails anti-p38 Antikörper Target Details p38 Anwendungsinformationen Handhabung Bilder zurück nach oben
Allgemeine Veröffentlichungen

Nemes, Petrovski, Aerts, Sergeant, Devreese, Fuesues: "Transglutaminase-mediated intramolecular cross-linking of membrane-bound alpha-synuclein promotes amyloid formation in Lewy bodies." in: The Journal of biological chemistry, Vol. 284, Issue 40, pp. 27252-64, 2009

Fan, Chen, Qiao, Luo, Ma, Li, Jiang, Niu, Yin: "Opposing effects of ERK and p38 MAP kinases on HeLa cell apoptosis induced by dipyrithione." in: Molecules and cells, Vol. 23, Issue 1, pp. 30-8, 2007

Medicherla, Protter, Ma, Mangadu, Almirez, Koppelman, Kerr, Navas, Movius, Reddy, Liu, Luedtke, Perumattam, Mavunkel, Dugar, Schreiner: "Preventive and therapeutic potential of p38 alpha-selective mitogen-activated protein kinase inhibitor in nonobese diabetic mice with type 1 diabetes." in: The Journal of pharmacology and experimental therapeutics, Vol. 318, Issue 1, pp. 99-107, 2006

Salojin, Owusu, Millerchip, Potter, Platt, Oravecz: "Essential role of MAPK phosphatase-1 in the negative control of innate immune responses." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 176, Issue 3, pp. 1899-907, 2006

Van Laethem, Van Kelst, Lippens, Declercq, Vandenabeele, Janssens, Vandenheede, Garmyn, Agostinis: "Activation of p38 MAPK is required for Bax translocation to mitochondria, cytochrome c release and apoptosis induced by UVB irradiation in human keratinocytes." in: FASEB journal : official publication of the Federation of American Societies for Experimental Biology, Vol. 18, Issue 15, pp. 1946-8, 2004

Deng, Ren, Yang, Lin, Wu: "A JNK-dependent pathway is required for TNFalpha-induced apoptosis." in: Cell, Vol. 115, Issue 1, pp. 61-70, 2003

Pearson, Robinson, Beers Gibson, Xu, Karandikar, Berman, Cobb: "Mitogen-activated protein (MAP) kinase pathways: regulation and physiological functions." in: Endocrine reviews, Vol. 22, Issue 2, pp. 153-83, 2001

Han, Lee, Bibbs, Ulevitch: "A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells." in: Science (New York, N.Y.), Vol. 265, Issue 5173, pp. 808-11, 1994

Bilder

Produktdetails anti-p38 Antikörper Target Details p38 Anwendungsinformationen Handhabung ProductDetails: References for anti-p38 antibody (ABIN361680) zurück nach oben
Bilder des Herstellers
 image for anti-p38 Antikörper (MAP kinase p38) (ABIN361680) p38 MAPkinase (9F12), human cell lines.