anti-Maus p38 Antikörper für Flow Cytometry

Recommended p38 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
MAP kinase p38 (p38) Antikörper
  • CSBP
  • CSBP1
  • CSBP2
  • CSPB1
  • EXIP
  • Mxi2
  • PRKM14
  • PRKM15
  • RK
  • SAPK2A
  • p38
  • p38ALPHA
  • mitogen-activated protein kinase 14
  • MAPK14
Epitop
pThr180
67
57
31
15
15
10
10
6
5
5
4
4
3
3
3
2
2
2
2
1
1
1
1
1
1
1
1
1
Reaktivität
Human, Maus, Ratte (Rattus)
280
222
216
38
22
22
21
20
19
18
18
18
15
15
12
4
1
1
Wirt
Maus
198
84
Klonalität
Monoklonal
Konjugat
Dieser p38 Antikörper ist unkonjugiert
7
7
7
7
6
5
3
3
3
3
3
3
3
3
3
3
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
2
1
1
1
1
1
Applikation
Flow Cytometry (FACS), Immunofluorescence (IF), Western Blotting (WB)
223
161
110
69
60
56
48
28
26
18
13
10
6
6
2
2
1
1
1
1
1
Optionen
Hersteller
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Bilder

Produktnummer ABIN968800
Preis und Verfügbarkeit auf Anfrage.
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN968799 FACS IF WB Mouse IgG1 pThr180 Anmelden zum Anzeigen 30-p38 MAPK 3
1 ABIN2737307 FACS IP IHC WB Rabbit IgG Anmelden zum Anzeigen Polyclonal
1 ABIN2666054 FACS Rabbit IgG Anmelden zum Anzeigen Polyclonal 5
1 ABIN2666053 FACS Rabbit IgG Anmelden zum Anzeigen Polyclonal
1 ABIN3059743 FACS IP IHC WB Rabbit Anmelden zum Anzeigen Polyclonal

General

Antigen MAP kinase p38 (p38) Antikörper
Epitop pThr180
(67), (57), (31), (15), (15), (10), (10), (6), (5), (5), (4), (4), (3), (3), (3), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reaktivität Human, Maus, Ratte (Rattus)
(280), (222), (216), (38), (22), (22), (21), (20), (19), (18), (18), (18), (15), (15), (12), (4), (1), (1)
Wirt Maus
(198), (84)
Klonalität (Klon)
Monoklonal   ( )
Konjugat Dieser p38 Antikörper ist unkonjugiert
(7), (7), (7), (7), (6), (5), (3), (3), (3), (3), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1)
Applikation Flow Cytometry (FACS), Immunofluorescence (IF), Western Blotting (WB)
(223), (161), (110), (69), (60), (56), (48), (28), (26), (18), (13), (10), (6), (6), (2), (2), (1), (1), (1), (1), (1)
Pubmed 3 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-p38 Antikörper

Target Details p38 Anwendungsinformationen Handhabung Referenzen für anti-p38 Antikörper (ABIN968800) Bilder
Kreuzreaktivität Maus, Ratte (Rattus)
Produktmerkmale 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Please refer to us for technical protocols.
Reinigung The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Immunogen Human p38 MAPK (pT180/pY182)
Klon 30-p38 MAPK
Isotyp IgG1

Target Details p38

Produktdetails anti-p38 Antikörper Anwendungsinformationen Handhabung Referenzen für anti-p38 Antikörper (ABIN968800) Bilder zurück nach oben
Antigen
Andere Bezeichnung p38 MAPK (p38 Antibody Abstract)
Hintergrund Activation of the immune and inflammatory responses often involves the recognition of bacterial endotoxin (lipopolysaccharide or LPS). Binding of LPS by monocytic cells results in the production and release of proinflammatory cytokines, such as IL-1 and TNF-alpha. LPS-induced signaling cascades involve members of the Ser/Thr protein kinase family known as the mitogen activated protein kinases (MAPKs). MAPK signal transduction pathways mediate the effects of various extracellular stimuli on biological processes such as proliferation, differentiation, and death. The p38 MAP kinases include p38alpha, beta, gamma, and delta. These ser/thr kinases are activated by dual phosphorylation on Thr and Tyr within the motif Thr-Gly-Tyr located in kinase subdomain VIII. Activation of p38 MAPK is mediated specifically by the MAP kinase kinases, MKK3, MKK4, and MKK6. This leads to the activation of multiple transcription factors (NF-kappaB, ATF-2, Elk-1, and CHOP) that induce expression of many different genes, including proinflammatory cytokine genes. Thus, p38 MAPKs are central kinases in muliple signal transduction pathways.
Molekulargewicht 38-42 kDa
Forschungsgebiet Kinases/Phosphatases
Pathways MAPK Signalweg, Neurotrophin Signalübertragung, Activation of Innate immune Response, Cellular Response to Molecule of Bacterial Origin, Regulation of Muscle Cell Differentiation, Hepatitis C, Toll-Like Receptors Cascades, Autophagie, Thromboxane A2 Receptor Signaling

Anwendungsinformationen

Produktdetails anti-p38 Antikörper Target Details p38 Handhabung Referenzen für anti-p38 Antikörper (ABIN968800) Bilder zurück nach oben
Kommentare

Related Products: ABIN968535, ABIN968632, ABIN967389, ABIN968769

Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-p38 Antikörper Target Details p38 Anwendungsinformationen Referenzen für anti-p38 Antikörper (ABIN968800) Bilder zurück nach oben
Format Liquid
Konzentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store undiluted at -20°C.

Referenzen für anti-p38 Antikörper (ABIN968800)

Produktdetails anti-p38 Antikörper Target Details p38 Anwendungsinformationen Handhabung Bilder zurück nach oben
Produkt verwendet in:

Winston, Chan, Johnson, Riches: "Activation of p38mapk, MKK3, and MKK4 by TNF-alpha in mouse bone marrow-derived macrophages." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 159, Issue 9, pp. 4491-7, 1997

Brunet, Pouysségur: "Identification of MAP kinase domains by redirecting stress signals into growth factor responses." in: Science (New York, N.Y.), Vol. 272, Issue 5268, pp. 1652-5, 1996

Han, Lee, Bibbs, Ulevitch: "A MAP kinase targeted by endotoxin and hyperosmolarity in mammalian cells." in: Science (New York, N.Y.), Vol. 265, Issue 5173, pp. 808-11, 1994

Bilder

Produktdetails anti-p38 Antikörper Target Details p38 Anwendungsinformationen Handhabung Referenzen für anti-p38 Antikörper (ABIN968800) zurück nach oben
Bilder des Herstellers
Western Blotting (WB) image for anti-MAP kinase p38 (p38) (pThr180) antibody (ABIN968800) Western blot analysis for p38 MAPK (pT180/pY182) (left figure). HeLa cells (Human cer...
Immunofluorescence (IF) image for anti-MAP kinase p38 (p38) (pThr180) antibody (ABIN968800) Immunofluorescence staining for p38 MAPK (pT180/pY182) (right figure). HeLa cells (Hu...