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These results identify MCL-1 as a critical prosurvival protein for preventing beta-cell death and clarify the mechanisms behind its downregulation by proinflammatory cytokines.
These data show that Mcl-1 is dispensable for the regulation of apoptosis during infection with different large DNA viruses.Bcl-XL, on the other hand, can be important to maintain survival of virus-infected cells
BCL-XL (zeige BCL2L1 Proteine) expression promotes survival of immature B cells, expression of BCL-2 (zeige BCL2 Proteine) is important for survival of mature B cells and long-lived plasma cells (PC), and expression of MCL-1 is important for survival throughout B-cell development.
miR (zeige MLXIP Proteine)-32/MCL-1 pathway members were identified as key early genetic events driving melanoma progression.
GSK3B-MCL1 signaling to regulate axonal autophagy might be important for the successful completion of Wallerian degeneration.
Specific downregulation of Mcl-1 significantly increases apoptosis of peritoneal macrophages and that the MAPK (zeige MAPK1 Proteine) signaling pathway is the primary mediator of Mcl-1 expression.
MCL1 plays a pivotal role in Leydig-cell steroidogenesis, and might provide novel insights into metabolic regulation in this cell
Although loss of one Mcl-1 allele did not noticeably impair the survival of normal B lymphoid cells, it markedly diminished the survival of Proto-Oncogene (zeige RAB1A Proteine) Proteins c-myc (zeige MYC Proteine) overexpressing B cell progenitors.
MCL-1 loss in early B-lymphoid progenitors delayed MYC (zeige MYC Proteine)-driven lymphomagenesis.
High Mcl-1 levels enhanced mTOR (zeige FRAP1 Proteine) phosphorylation and augmented the differentiation of terminal effector cells and effector memory CD8 (zeige CD8A Proteine) T cells.
Treatment with vorinostat and sorafenib synergistically induces apoptosis in chronic myelogenous leukemia cells through a process that involves Mcl1 down-regulation and inhibition of p21(CIP1 (zeige CDKN1A Proteine)) induction.
HB-EGF (zeige HBEGF Proteine) is implicated in DNA double strand breaks repair as silencing of HB-EGF (zeige HBEGF Proteine) increased gammaH2AX (zeige H2AFX Proteine) foci half-life as well as USP9X (zeige USP9X Proteine) expression, two features that could be linked to the observed effect on Mcl-1.
Augmentation of proteasome activity had a critical role in downregulation of Mcl-1 and c-FLIP (zeige CFLAR Proteine) expression at the post-translational level.
These findings provide new insights into MCL-1 ligands, and the interplay between DRP-1 (zeige CRMP1 Proteine) and the anti-apoptotic BCL-2 (zeige BCL2 Proteine) family members in the regulation of apoptosis
the c-FLIP (zeige CFLAR Proteine) and NOXA (zeige PMAIP1 Proteine)/Mcl-1 axis participated in the synergistic effect of pemetrexed plus cisplatin in human choroidal melanoma cells
that inhibition of Mcl-1 expression by siRNA considerably enhanced Pevonedistat-triggered the activation of caspase-3 (zeige CASP3 Proteine), PARP cleavage and apoptosis
Targeted Mcl-1 blockade using RNAi increased caspase (zeige CASP3 Proteine)-mediated cell death in ERalpha (zeige ESR1 Proteine)(+) breast cancer cells, resulting in sustained growth inhibition.
Expression level of MCL-1 is upregulated in renal cell carcinoma (zeige MOK Proteine).
Study indicates that two distinct micro-environmental factors, CD40L (zeige CD40LG Proteine) and Mphis, signal via CCR1 to induce AKT (zeige AKT1 Proteine) activation resulting in translational stabilization of MCL-1, and hence can contribute to CLL cell survival.
This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing.
bcl-2-related protein EAT/mcl1
, induced myeloid leukemia cell differentiation protein Mcl-1 homolog
, bcl-2-like protein 3
, induced myeloid leukemia cell differentiation protein Mcl-1
, myeloid cell leukemia ES
, myeloid cell leukemia protein 1