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These results identify MCL-1 as a critical prosurvival protein for preventing beta-cell death and clarify the mechanisms behind its downregulation by proinflammatory cytokines.
These data show that Mcl-1 is dispensable for the regulation of apoptosis during infection with different large DNA viruses.Bcl-XL, on the other hand, can be important to maintain survival of virus-infected cells
BCL-XL (zeige BCL2L1 ELISA Kits) expression promotes survival of immature B cells, expression of BCL-2 (zeige BCL2 ELISA Kits) is important for survival of mature B cells and long-lived plasma cells (PC), and expression of MCL-1 is important for survival throughout B-cell development.
miR (zeige MLXIP ELISA Kits)-32/MCL-1 pathway members were identified as key early genetic events driving melanoma progression.
GSK3B (zeige GSK3b ELISA Kits)-MCL1 signaling to regulate axonal autophagy might be important for the successful completion of Wallerian degeneration.
Specific downregulation of Mcl-1 significantly increases apoptosis of peritoneal macrophages and that the MAPK (zeige MAPK1 ELISA Kits) signaling pathway is the primary mediator of Mcl-1 expression.
MCL1 plays a pivotal role in Leydig-cell steroidogenesis, and might provide novel insights into metabolic regulation in this cell
Although loss of one Mcl-1 allele did not noticeably impair the survival of normal B lymphoid cells, it markedly diminished the survival of Proto-Oncogene (zeige RAB1A ELISA Kits) Proteins c-myc (zeige MYC ELISA Kits) overexpressing B cell progenitors.
MCL-1 loss in early B-lymphoid progenitors delayed MYC (zeige MYC ELISA Kits)-driven lymphomagenesis.
High Mcl-1 levels enhanced mTOR (zeige FRAP1 ELISA Kits) phosphorylation and augmented the differentiation of terminal effector cells and effector memory CD8 (zeige CD8A ELISA Kits) T cells.
PTBP1 (zeige PTBP1 ELISA Kits) is a novel regulator of MCL1 mRNA by which it controls apoptotic response to antitubulin chemotherapeutics.
our results provide new insights into the critical role of NCTD in suppressing Mcl-1 via epigenetic upregulation of miR (zeige MLXIP ELISA Kits)-320d, resulting in PCa (zeige FLVCR1 ELISA Kits) cell apoptosis
knockdown of NAP1L1 (zeige NAP1L1 ELISA Kits) suppresses IkappaBalpha (zeige NFKBIA ELISA Kits) degradation and nuclear transport of p65 (zeige GORASP1 ELISA Kits) subunit after treatment with TNF-a (zeige TNF ELISA Kits) stimulation, leading to attenuation of the NF-kappaB (zeige NFKB1 ELISA Kits) transcriptional activity, whereas NAP1L4 (zeige NAP1L4 ELISA Kits) knockdown remains silent.results of this study suggest that NAP1L1 (zeige NAP1L1 ELISA Kits) downregulation renders the cell vulnerable to apoptotic cell death through attenuation of NF-kappaB (zeige NFKB1 ELISA Kits) transcriptional activity on the anti-apop...
induction of MCL-1 by IL-6 (zeige IL6 ELISA Kits)/IL-8 (zeige IL8 ELISA Kits) may surmount any direct down-regulation by miR (zeige MLXIP ELISA Kits)-29b via its 3'-UTR (zeige UTS2R ELISA Kits).
HB-EGF (zeige HBEGF ELISA Kits) is implicated in DNA double strand breaks repair as silencing of HB-EGF (zeige HBEGF ELISA Kits) increased gammaH2AX (zeige H2AFX ELISA Kits) foci half-life as well as USP9X (zeige USP9X ELISA Kits) expression, two features that could be linked to the observed effect on Mcl-1.
Augmentation of proteasome activity had a critical role in downregulation of Mcl-1 and c-FLIP (zeige CFLAR ELISA Kits) expression at the post-translational level.
These findings provide new insights into MCL-1 ligands, and the interplay between DRP-1 (zeige CRMP1 ELISA Kits) and the anti-apoptotic BCL-2 (zeige BCL2 ELISA Kits) family members in the regulation of apoptosis
the c-FLIP (zeige CFLAR ELISA Kits) and NOXA (zeige PMAIP1 ELISA Kits)/Mcl-1 axis participated in the synergistic effect of pemetrexed plus cisplatin in human choroidal melanoma cells
that inhibition of Mcl-1 expression by siRNA considerably enhanced Pevonedistat-triggered the activation of caspase-3 (zeige CASP3 ELISA Kits), PARP (zeige COL11A2 ELISA Kits) cleavage and apoptosis
This gene encodes an anti-apoptotic protein, which is a member of the Bcl-2 family. Alternative splicing results in multiple transcript variants. The longest gene product (isoform 1) enhances cell survival by inhibiting apoptosis while the alternatively spliced shorter gene products (isoform 2 and isoform 3) promote apoptosis and are death-inducing.
bcl-2-related protein EAT/mcl1
, induced myeloid leukemia cell differentiation protein Mcl-1 homolog
, bcl-2-like protein 3
, induced myeloid leukemia cell differentiation protein Mcl-1
, myeloid cell leukemia ES
, myeloid cell leukemia protein 1