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Erk5 role in the cardiac mitochondria and the Pgc-1alpha (zeige PPARGC1A ELISA Kits) regulation
FOXF1 (zeige FOXF1 ELISA Kits) promotes prostate tumor growth and progression by activating ERK5 signaling
Erk5 MAP kinase (zeige MAPK1 ELISA Kits) is activated in response to PDGF (zeige PDGFA ELISA Kits)-BB in the smooth muscle cell line MOVAS in a manner dependent on Mekk2 (zeige MAP3K2 ELISA Kits), Mek1 (zeige MAP2K1 ELISA Kits)/2, Mek5 (zeige MAP2K5 ELISA Kits), PI3-kinase (zeige PIK3CA ELISA Kits) and protein kinase C (PKC (zeige PKC ELISA Kits)).
Using compound selectivity engineering and CRISPR/Cas9 genome editing, distinct functions for Erk5 and Brd4 (zeige BRD4 ELISA Kits) in pluripotency regulation of mouse embryonic stem cells have been revealed.
These results suggest that YAP (zeige YAP1 ELISA Kits) promotes muscle differentiation by activating the Abl (zeige ABL1 ELISA Kits)/Src (zeige SRC ELISA Kits)/MEKK3 (zeige MAP3K3 ELISA Kits)/MEK5 (zeige MAP2K5 ELISA Kits)/ERK5 kinase cascade.
our results offer a preclinical proof of concept for ERK5 as a target to enhance T-cell infiltrates in prostate cancer
This study indicated that MAN can protect osteoblast against oxidative damage by modulation of ERK5/Nrf2 (zeige NFE2L2 ELISA Kits) signaling, which can be new agent for osteoporosis.
These findings suggest that atherogenic conditions critically regulate platelet CD36 (zeige CD36 ELISA Kits) signaling by increasing superoxide radical anion and hydrogen peroxide through a mechanism that promotes activation of MAPK (zeige MAPK1 ELISA Kits) ERK5.
Fluid shear stress acts on the Galphaq (zeige GNAQ ELISA Kits)-ERK5 signaling pathway to upregulate Cyclin B1 (zeige CCNB1 ELISA Kits) and CDK1 (zeige CDK1 ELISA Kits) expression, thereby resulting in MC3T3-E1 cell proliferation.
Finally, we demonstrated that miR (zeige MLXIP ELISA Kits)-24 plays the modulational role by directly repressing MAPK7, a key number in the MAPK (zeige MAPK1 ELISA Kits) signaling pathway. These data indicate that miR (zeige MLXIP ELISA Kits)-24 is a novel positive regulator of adipocyte differentiation by targeting MAPK7, which provides new insights into the molecular mechanism of miRNA-mediated cellular differentiation.
CCh induced TGF-beta1 (zeige TGFB1 ELISA Kits) self-sustaining signaling loops by potentiating ERK5 signaling and promoted myofibroblast activity. This autocrine signaling mechanism may be an attractive therapeutic target to block the fibrotic response, which was modulated by the combination of glycopyrronium and indacaterol.
In the current study, five structures of the ERK5 kinase domain co-crystallized with ERK5 inhibitors are reported. Interestingly, three of the compounds bind at a novel allosteric binding site in ERK5, while the other two bind at the typical ATP-binding site.
Our results indicate that overexpression of MAPK7 in human OS cells could promote cell proliferation, migration and invasion, whereas knockdown of MAPK7 expression had the opposite effect. All the results suggest that MAPK7 may serve as a potent target for drug development.
Statin mediated ERK5 activation and the resulting decrease in cardiac endothelial cell permeability may contribute to the cardioprotective effects of statins in reducing doxorubicin-induced cardiotoxicity.
expression of miR (zeige MLXIP ELISA Kits)-143 in osteosarcoma cells inhibited cell proliferation and migration/invasion. Bioinformatics and luciferase reporter assays confirmed that MAPK7 was targets gene of miR (zeige MLXIP ELISA Kits)-143.
miR (zeige MLXIP ELISA Kits)-143 down-regulated its target ERK5, leading to the suppression of epithelial-mesenchymal transition induced by GSK-3beta (zeige GSK3b ELISA Kits)/Snail (zeige SNAI1 ELISA Kits) signaling of breast cancer.
this study revealed the functional and mechanistic links between CDK5 (zeige CDK5 ELISA Kits) and the oncogenic ERK5-AP-1 (zeige FOSB ELISA Kits) signaling pathway in the pathogenesis of colorectal cancer.
Present study revealed the positive role of ERK5/AP-1 (zeige FOSB ELISA Kits) in benzidine-provoked urocystic epithelial-mesenchymal transition and the curcumin promising use in bladder cancer prevention and intervention via ERK5/AP-1 (zeige FOSB ELISA Kits) pathway.
Data showed that expression of the MKK7 (zeige MAP2K7 ELISA Kits) gene in wild-type plants is induced by pathogen infection. Reducing mRNA levels of MKK7 (zeige MAP2K7 ELISA Kits) by antisense RNA expression not only compromises basal resistance, but also blocks the induction of SAR (zeige SRL ELISA Kits).
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is specifically activated by mitogen-activated protein kinase kinase 5 (MAP2K5/MEK5). It is involved in the downstream signaling processes of various receptor molecules including receptor type kinases, and G protein-coupled receptors. In response to extracelluar signals, this kinase translocates to cell nucleus, where it regulates gene expression by phosphorylating, and activating different transcription factors. Four alternatively spliced transcript variants of this gene encoding two distinct isoforms have been reported.
, MAP kinase 4
, MAPK 4
, extracellular signal-regulated kinase 4
, mitogen activated protein kinase 4
, MAP kinase isoform p63
, BMK1 kinase
, MAP kinase 7
, MAPK 7
, big MAP kinase 1
, extracellular signal-regulated kinase 5
, extracellular-signal-regulated kinase 5
, extracellular signal regulated kinase 5
, mitogen activated protein kinase 7
, mitogen-activated kinase 7
, Big MAP kinase 1
, Extracellular signal-regulated kinase 5