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Human MAPK14 Protein expressed in Baculovirus infected Insect Cells - ABIN2002027
Tamura, Sudo, Senftleben, Dadak, Johnson, Karin: Requirement for p38alpha in erythropoietin expression: a role for stress kinases in erythropoiesis. in Cell 2000
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results suggest that ET-1 (zeige EDN1 Proteine)-induced activation of proMMP-2 is mediated via cross-talk between NADPH oxidase (zeige NOX1 Proteine)-PKCalpha (zeige PKCa Proteine)-p(38)MAPK (zeige MAPK1 Proteine) and NFkappaB-MT1MMP (zeige MMP14 Proteine) signaling pathways along with a marked decrease in TIMP-2 (zeige TIMP2 Proteine) expression in the cells
cross-talk between p(38)MAPK (zeige MAPK1 Proteine) and Gialpha play a pivotal role for full activation of cPLA2 (zeige PLA2G4A Proteine) during ET-1 (zeige EDN1 Proteine) stimulation of pulmonary artery smooth muscle cells.
MAPK14 signalling pathway is largely involved in heat-induced sperm damage.
p38 MAPK is an early redox sensor in the laminar shear stress with hydrogen peroxide being a signaling mediator.
Blockade of p38 enhances chondrocyte phenotype in monolayer culture and may promote more efficient cartilage tissue regeneration for cell-based therapies.
p38 phosphorylation and MMP13 (zeige MMP13 Proteine) expression are regulated by Rho/ROCK activation, and support the potential novel pathway that Rho/ROCK is in the upper part of the mechanical stress-induced matrix degeneration cascade in cartilage.
These data suggest that the p38 and JNK (zeige MAPK8 Proteine) signaling pathways play pivotal roles in PRRSV replication and may regulate immune responses during virus infection.
findings support the hypothesis that ischemic factor stimulation of the blood-brain barrier Na-K-Cl cotransporter (zeige SLC12A1 Proteine) involves activation of p38 and JNK (zeige MAPK8 Proteine) MAPKs
These data suggest a differential requirement of JNK1 (zeige MAPK8 Proteine) and p38 MAPK in TNF (zeige TNF Proteine) regulation of E2F1 (zeige E2F1 Proteine). Targeted inactivation of JNK1 (zeige MAPK8 Proteine) at arterial injury sites may represent a potential therapeutic intervention for ameliorating TNF (zeige TNF Proteine)-mediated EC dysfunction.
p38 MAPK (MAPK14) is redox-regulated in reactive oxygen species-dependent endothelial barrier dysfunction.
ROS (zeige ROS1 Proteine)/JNK (zeige MAPK8 Proteine)/p38/Upd (zeige UROD Proteine) stress responsive module restores tissue homeostasis. This module is not only activated after cell death induction but also after physical damage and reveals one of the earliest responses for imaginal disc regeneration.
Taken together, our findings indicate that the p38 MAP Kinase is an integral component of the core circadian clock of Drosophila in addition to playing a role in stress-input pathways.
Data show that the genetic interaction between p38b MAPK (zeige MAPK1 Proteine) and Rack1 (zeige GNB2L1 Proteine) controls muscle aggregate formation, locomotor function, and longevity.
The interaction of any of several Drosophila Delta class glutathione transferases and p38b mitogen-activated protein kinase (zeige MAPK1 Proteine) can affect the substrate specificity of either enzyme, which suggests induced conformational changes affecting catalysis.
found a correlation between the depth of integration of individual p38 kinases into the protein interaction network and their functional significance; propose a central role of p38b in the p38 signaling module with p38a and p38c playing more peripheral auxiliary roles
Loss of p38 MAPK causes early lethality and precipitates age-related motor dysfunction and stress sensitivity.
The p38 pathway-mediated stress response contribute to Drosophila host defense against microbial infection.
p38b MAPK (zeige MAPK1 Proteine) plays a crucial role in the balance between intestinal stem cell proliferation and proper differentiation in the adult Drosophila midgut.
the D-p38b gene is regulated by the DREF (zeige ZBED1 Proteine) pathway and DREF (zeige ZBED1 Proteine) is involved in the regulation of proliferation and differentiation of Drosophila ISCs (zeige NFS1 Proteine) and progenitors
p38 mitogen-activated protein kinase is crucial for bovine papillomavirus type-1 transformation of equine fibroblasts.
p38 Mitogen-activated protein kinase (MAPK (zeige MAPK1 Proteine)) is essential for drug-induced COX-2 (zeige PTGS2 Proteine) expression in leukocytes, suggesting that p38 MAPK is a potential target for anti-inflammatory therapy.
These findings support a function for p38 MAPK in equine neutrophil migration and suggest the potential for the ability of p38 MAPK inhibition to limit neutrophilic inflammation in the laminae during acute laminitis.
Cultured equine digital vein endothelial cells were exposed to lipopolysaccharide and phosphorylation of p38 MAPK was assessed by Western blotting using phospho-specific antibodies.
S. aureus evades phagophores and prevents further degradation by a MAPK14/p38alpha MAP kinase (zeige MAPK1 Proteine)-mediated blockade of autophagy.
p38 (zeige CRK Proteine)-dependent mechanism that phosphorylates GATA-2 (zeige GATA2 Proteine) and increases GATA-2 (zeige GATA2 Proteine) target gene activation has been demonstrated. This mechanism establishes a growth-promoting chemokine (zeige CCL1 Proteine)/cytokine circuit in acute myeloid leukemia (zeige BCL11A Proteine) cells.
our results strongly indicate that the crosstalk between p38 (zeige CRK Proteine) and Akt (zeige AKT1 Proteine) pathways can determine special AT-rich sequence-binding protein 2 (zeige SATB2 Proteine) expression and epithelial character of non-small-cell lung carcinoma cells
Osmotic stress promotes TEAD4 (zeige TEAD4 Proteine) cytoplasmic translocation via p38 MAPK in a Hippo-independent manner. Stress-induced TEAD inhibition predominates YAP (zeige YAP1 Proteine)-activating signals and selectively suppresses YAP (zeige YAP1 Proteine)-driven cancer cell growth.
TGF-beta (zeige TGFB1 Proteine) induces p38alpha (mitogen-activated protein kinase 14 [MAPK14]), which in turn phosphorylates NR4A1 (zeige NR4A1 Proteine), resulting in nuclear export of the receptor.
Data suggest that suppression of nonsense-mediated RNA decay due to persistent DNA damage (from exposure to either mutagens, gamma rays, or oxidative stress) requires the activity of p38alpha MAPK (zeige MAPK1 Proteine) (MAPK14, mitogen-activated protein kinase 14, MAP kinase p38 alpha); mRNA of ATF3 (activating transcription factor 3 (zeige ATF3 Proteine)) is stabilized by persistent DNA damage in a p38alpha MAPK (zeige MAPK1 Proteine)-dependent manner.
VEGF (zeige VEGFA Proteine)-activated p38alpha phosphorylates coronin 1B (zeige CORO1B Proteine) at Ser2 (zeige JAG2 Proteine) and activates the Arp2 (zeige ACTR2 Proteine)/3 complex by liberating it from coronin 1B (zeige CORO1B Proteine).
findings show that endothelial MAPKs ERK (zeige EPHB2 Proteine), p38 (zeige CRK Proteine), and JNK (zeige MAPK8 Proteine) mediate diapedesis-related and diapedesis-unrelated functions of ICAM-1 (zeige ICAM1 Proteine) in cerebral and dermal microvascular endothelial cells
Tetraarsenic hexoxide (As4O6) induced G2/M arrest, apoptosis and autophagic cell death through PI3K (zeige PIK3CA Proteine)/Akt (zeige AKT1 Proteine) and p38 MAPK pathways alteration in SW620 colon cancer cells.
The N-Terminal phosphorylation of RB by p38 (zeige CRK Proteine) bypasses its inactivation by cyclin (zeige PCNA Proteine)-dependent kinases and prevents proliferation in cancer cells.
P38 MAPK-mediated YAP (zeige YAP1 Proteine) activation controls mechanical-tension-induced pulmonary alveolar regeneration.
The anti-inflammatory functions of p38 MAPK in macrophages are critically dependent on production of IL-10 (zeige IL10 Proteine).
this study shows that peripheral deletion of CD8 (zeige CD8A Proteine) T cells requires p38 MAPK in cross-presenting dendritic cells
Distal retinal ganglion cell axon transport loss and activation of p38 MAPK stress pathway following VEGF-A (zeige VEGFA Proteine) antagonism have been documented.
p38MAPK/MK2 (zeige KCNA2 Proteine) phosphorylation of RIPK1 (zeige RIPK1 Proteine) is a crucial checkpoint for cell fate in inflammation and infection that determines the outcome of bacteria-host cell interaction.
Data suggest that Mapk14/p38alpha is activated and forms cystine disulfide-bound heterodimer with Map2k3/Mkk3 (zeige MAP2K3 Proteine) in cardiomyocytes and isolated hearts during oxidative stress. (Mapk14, mitogen-activated protein kinase 14; Mkk3 (zeige MAP2K3 Proteine) = mitogen-activated protein kinase kinase 3 (zeige MAP2K3 Proteine))
High-glucose induces tau hyperphosphorylation through activation of TLR9 (zeige TLR9 Proteine)-P38 MAPK pathway.
Doxorubicin (Dox)-administration to cardiomyocytes increased the levels of reactive oxygen species (ROS (zeige ROS1 Proteine)) in a time-dependent manner that followed the activation of stress-induced proteins p53 (zeige TP53 Proteine), p38 (zeige CRK Proteine) and JNK (zeige MAPK8 Proteine) MAPKs, culminating in an increase in autophagy and apoptosis markers.
Soluble epoxide hydrolase (zeige EPHX2 Proteine) inhibitor AUDA decreases bleomycin-induced pulmonary toxicity in mice by inhibiting the p38 (zeige CRK Proteine)/Smad3 (zeige SMAD3 Proteine) signaling pathway.
These findings suggest that the TQ-induced production of ROS (zeige ROS1 Proteine) causes dedifferentiation through the ERK (zeige MAPK1 Proteine) pathway and inflammation through the PI3K and p38 pathways in rabbit articular chondrocytes.
These results suggest that p38 MAPK signal transduction pathway is critical to NO-induced chondrocyte apoptosis, and p38 plays a role by way of stimulating NF-kappaB (zeige NFKB1 Proteine), p53 (zeige TP53 Proteine) and caspase-3 (zeige CASP3 Proteine) activation.
Porcine reproductive and respiratory syndrome virus strain CH-1a could significantly up-regulate IL-10 (zeige IL10 Proteine) production through p38 MAPK activation.
JNK (zeige MAPK8 Proteine) plays an active role in fragmentation of pig oocytes and p38 MAPK is not involved in this process.[p38MAPK]
Retinal ischemia-reperfusion alters expression of mitogen-activated protein kinases, particularly ERK1/2, in the neuroretina and retinal arteries.
cytochrome c (zeige CYCS Proteine) microinjection induces p38 phosphorylation through caspase-3 (zeige CASP3 Proteine) activation, and caspase (zeige CASP3 Proteine) inhibition reduces p38 activation induced by osmostress, indicating that a positive feedback loop is engaged by hyperosmotic shock
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various environmental stresses and proinflammatory cytokines. The activation requires its phosphorylation by MAP kinase kinases (MKKs), or its autophosphorylation triggered by the interaction of MAP3K7IP1/TAB1 protein with this kinase. The substrates of this kinase include transcription regulator ATF2, MEF2C, and MAX, cell cycle regulator CDC25B, and tumor suppressor p53, which suggest the roles of this kinase in stress related transcription and cell cycle regulation, as well as in genotoxic stress response. Four alternatively spliced transcript variants of this gene encoding distinct isoforms have been reported.
MAP kinase 14
, MAP kinase p38 alpha
, MAPK 14
, mitogen-activated protein kinase p38 alpha
, p38 mitogen activated protein kinase
, p38 mitogen-activated protein kinase
, stress-activated p38b MAP kinase
, p38 mitogen-activated kinase
, cytokine suppressive anti-inflammatory drug binding protein 1
, mitogen activated protein kinase 14
, p38 MAP kinase alpha
, p38 MAPK
, p38 alpha
, tRNA synthetase cofactor p38
, CSAIDS-binding protein 1
, mitogen-activated protein kinase 14A
, stress-activated protein kinase 2a
, Csaids binding protein
, MAP kinase 2
, MAP kinase Mxi2
, MAX-interacting protein 2
, cytokine suppressive anti-inflammatory drug binding protein
, cytokine-supressive anti-inflammatory drug binding protein
, mitogen-activated protein kinase 14
, p38 MAP kinase
, p38alpha Exip
, reactive kinase
, stress-activated protein kinase 2A
, MAPK p38
, Mitogen-activated protein kinase 2
, mitogen-activated Mitogen-activated protein kinase 2