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Results provide evidence that p38beta is an unusual enzyme that automodulates its basal, MAPKK-independent activity by several autophosphorylation events, which enhance and suppress its catalytic activity.
p38beta was significantly higher in esophageal squamous cell carcinoma tissues compared with paired normal controls. p38beta expression was observed to be significantly associated with overall prognosis.
Suggest that R-Ras regulates angiogenic activities of endothelial cells in part via inhibition of the p38MAPK-HSP27 axis of VEGF signaling.
These findings suggest that coronin 1A (zeige CORO1A ELISA Kits) modulates endothelial cell apoptosis by regulating p38beta expression and activation.
The MAPK11 gene was variably methylated in monozygotic twins discordant for depressive disorder.
p38beta is a novel regulatory target of the transcription factor Pokemon (zeige ZBTB7A ELISA Kits) and positively regulated by Pokemon (zeige ZBTB7A ELISA Kits) in hepatic cells.
Data show that the p38 MAPK (p38 (zeige MAPK14 ELISA Kits)) isoform (p38beta) mitogen-activated protein kinase 11 (MAPK11) is expressed in breast cancer cell.
Differential roles for p38alpha (zeige MAPK14 ELISA Kits) and p38beta in the HGF (zeige HGF ELISA Kits)-induced expression of key osteogenic markers.
study identified the structural motif responsible for the unique autophosphorylation capability of p38beta and the motif inhibiting this activity in living cells
Study identifies Hsp27 (zeige HSPB1 ELISA Kits) as a novel target of ILK (zeige ILK ELISA Kits)-p38beta signaling complexes, playing a key role in bladder cancer cell migration.
propose that active p38-Mapk14 (zeige MAPK14 ELISA Kits)/11 act as enablers, and Erk1/2 (zeige MAPK1/3 ELISA Kits) as drivers, of primitive endoderm differentiation during inner cell mass lineage specification and segregation.
Double deficiency of p38alpha (zeige MAPK14 ELISA Kits) and p38beta in naive CD4 (zeige CD4 ELISA Kits)(+) T cells resulted in an attenuation of MAPK (zeige MAPK1 ELISA Kits)-activated protein kinase (zeige CDK7 ELISA Kits) (MK)-dependent mTOR (zeige FRAP1 ELISA Kits) signaling after T cell receptor engagement, and enhanced their differentiation into regulatory T cells under appropriate inducing conditions.
Data indicate that alternatively activated p38alpha (zeige MAPK14 ELISA Kits) and p38beta up-regulates the transcription factors NFATc1 (zeige NFATC1 ELISA Kits) and IRF4 (zeige IRF4 ELISA Kits).
the cell autonomous defect in self-renewal in satellite cells from aged mice is due to an impaired response to FGF ligands and elevated p38alpha (zeige MAPK14 ELISA Kits)/beta MAPK (zeige MAPK1 ELISA Kits) activity
work reveals a 'seed and soil' mechanism where TGF-beta2 (zeige TGFB2 ELISA Kits) and TGF-beta (zeige TGFB1 ELISA Kits)-RIII signalling through p38alpha (zeige MAPK14 ELISA Kits)/beta regulates DTC dormancy and defines restrictive (BM) and permissive (lung) microenvironments for HNSCC metastasis
Results suggest that UBR2 (zeige UBR2 ELISA Kits) up-regulation in cachectic muscle is mediated by the p38beta-C/EBPbeta (zeige CEBPB ELISA Kits) signaling pathway responsible for the bulk of tumor-induced muscle proteolysis.
inhibition of the SOCE downstream target CaM kinase kinase beta (zeige CAMKK2 ELISA Kits) (CaMKKbeta) or knockdown of AMPKalpha1 (zeige PRKAA1 ELISA Kits) suppressed PAR-1 (zeige MARK2 ELISA Kits)-mediated phosphorylation of p38beta and hence STIM1 (zeige STIM1 ELISA Kits).
p27 (zeige CDKN1B ELISA Kits) inhibition of COX-2 (zeige COX2 ELISA Kits) expression was specifically due to phosphorylation of transcription factor cAMP response element binding (CREB (zeige CREB1 ELISA Kits)) phosphorylation mediated by p38beta and p38delta (zeige MAPK1/3 ELISA Kits).
p38beta MAPK (zeige MAPK1 ELISA Kits) is dispensable in the brain in regards to proinflammatory cytokine production and neurotoxicity induced by LPS (zeige TLR4 ELISA Kits) inflammatory insult
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation, and development. This kinase is most closely related to p38 MAP kinase, both of which can be activated by proinflammatory cytokines and environmental stress. This kinase is activated through its phosphorylation by MAP kinase kinases (MKKs), preferably by MKK6. Transcription factor ATF2/CREB2 has been shown to be a substrate of this kinase.
mitogen-activated protein kinase 11
, mitogen-activated protein kinase 11-like
, MAP kinase 11
, MAP kinase p38 beta
, MAPK 11
, mitogen-activated protein kinase p38 beta
, mitogen-activated protein kinase p38-2
, stress-activated protein kinase 2
, stress-activated protein kinase 2b
, stress-activated protein kinase-2
, stress-activated protein kinase-2b
, mitogen activated protein kinase 11
, protein kinase, mitogen activated kinase, 11, p38beta