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anti-Human MAP4K3 Antikörper:
anti-Mouse (Murine) MAP4K3 Antikörper:
anti-Rat (Rattus) MAP4K3 Antikörper:
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Authors report that miR (zeige MLXIP Antikörper)-199a-5p and let-7c cooperatively and efficiently inhibit HCC (zeige FAM126A Antikörper) cell migration and invasion by targeting the metastasis promoter MAP4K3 and MAP4K3-mediated drug sensitization.
This report details the first structure of GLK (zeige GCK Antikörper); comparison of its activation loop sequence and P-loop structure to that of Map4k4 (zeige MAP4K4 Antikörper) suggests ideas for designing inhibitors that can distinguish between these family members to achieve selective pharmacological inhibitors.
ITGB3 (zeige ITGB3 Antikörper) and MAP4K3 are directly repressed by let-7c, altering the metastatic potential of lung cancer cells.
MAP4K3 expression is required for leucine-induced mTORC1 activation in human primary fibroblasts.
Significantly higher median frequencies of circulating GLK (zeige GCK Antikörper)-expressing T-cells were observed in patients with adult-onset Still's disease (31.85%) than in healthy volunteers (8.93%, P <0.001).
Amino acid sufficiency phosphorylates MAP4K3/Ser170, activating mTORC1, but amino acid restriction causes MAP4K3 to interact with PP2A (zeige PPP2R4 Antikörper)(T61 epsilon), promoting dephosphorylation of Ser170, MAP4K3 inhibition, and, inhibition of mTORC1 signaling.
MAP4K3 orchestrates activation of BAX (zeige BAX Antikörper) via the concerted posttranscriptional modulation of PUMA (zeige BBC3 Antikörper), BAD, and BIM (zeige BCL2L11 Antikörper).
This gene encodes a member of the mitogen-activated protein kinase kinase kinase kinase family. The encoded protein activates key effectors in cell signalling, among them c-Jun. Alternatively spliced transcripts encoding multiple isoforms have been observed for this gene.
MAPK/ERK kinase kinase kinase 3
, MEK kinase kinase 3
, germinal center kinase-like kinase
, germinal center kinase-related protein kinase
, MEKKK 3
, mitogen activated protein kinase kinase kinase kinase 3