MAP3K2 Proteine (MAP3K2)

Bezeichnung:
Mitogen-Activated Protein Kinase Kinase Kinase 2 Proteine (MAP3K2)
Auf www.antikoerper-online.de finden Sie aktuell 7 Mitogen-Activated Protein Kinase Kinase Kinase 2 (MAP3K2) Proteine von 5 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen MAP3K2 Antikörper (55) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 68 MAP3K2 Produkte verfügbar.
Synonyme:
9630061B06Rik, AI585793, MEKK2, Mekk2b
alle Proteine anzeigen Gen GeneID UniProt
Ratte MAP3K2 MAP3K2 171492  
MAP3K2 10746 Q9Y2U5
MAP3K2 26405  

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Human Mitogen-Activated Protein Kinase Kinase Kinase 2 (MAP3K2) Interaktionspartner

  1. miR (zeige MLXIP Proteine)-34c-3p may regulate triple-negative breast cancer progression by directly targeting the 3'-untranslated region of mitogen-activated protein kinase kinase kinase 2 (MAP3K2).

  2. Study found miR (zeige MLXIP Proteine)-186 expression significantly decreased in lung cancer tissues and cells and MAP3K2 expression increased in the same cancer tissues. Also, results confirmed that MAP3K2 is a target gene of miR (zeige MLXIP Proteine)-186 and both expression correlated with prognosis.

  3. SMYD3-mediated methylation of MAP3K2 increases mutant K-Ras-induced activation of ERK1/2. (Review)

  4. Restoration of miR17/20a in solid tumor cells enhances the natural killer cell antitumor activity by targeting Mekk2

  5. HBXIP (zeige HBXIP Proteine) activated ERK1/2 through up-regulating MEKK2.

  6. MEKK2 has a novel function as a regulator of ubiquitylation-dependent paxillin (zeige PXN Proteine) redistribution in breast tumour cells.

  7. EBV microRNA BART (zeige BSND Proteine) 18-5p targets MAP3K2 to facilitate persistence in vivo by inhibiting viral replication in B cells.

  8. Inhibitors of apoptosis proteins regulate myogenic differentiation by directly suppressing MEKK2/3-MEK5 (zeige MAP2K5 Proteine)-ERK5 (zeige MAPK7 Proteine) signaling.

  9. methylation of MAP3K2 by SMYD3 increases MAP kinase signalling and promotes the formation of Ras-driven carcinomas

  10. results strongly support a role for MEKK2 as a regulator of signaling that modulates breast tumor cell spread area and migration through control of focal adhesion stability

Mouse (Murine) Mitogen-Activated Protein Kinase Kinase Kinase 2 (MAP3K2) Interaktionspartner

  1. FGF2 (zeige FGF2 Proteine)/MEKK2 pathway mediates an alternative nonclassical pathway for beta-catenin (zeige CTNNB1 Proteine) activation, and this pathway is a key regulator of bone formation by osteoblasts

  2. Stk38 (zeige STK38 Proteine) protein kinase (zeige CDK7 Proteine) has a role in inhibiting TLR9 (zeige TLR9 Proteine)-activated inflammatory responses by promoting MEKK2 ubiquitination in macrophages

  3. methylation of MAP3K2 by SMYD3 increases MAP kinase signalling and promotes the formation of Ras-driven carcinomas

  4. MEKK2 is regulated through a phosphorylation-dependent association with 14-3-3 (zeige YWHAQ Proteine), a group of adapters that modulate dimerization and association between proteins

  5. MEKK2 signaling contributes to right ventricular hypertrophy and altered myocardial inflammatory gene expression in response to hypoxia-induced pulmonary hypertension.

  6. MEKK2 alone can suppress T-cell TGF-beta (zeige TGFB1 Proteine) responses. MEKK2 or MEKK3 (zeige MAP3K3 Proteine) can cause ERK1/2 to phosphorylate SMAD2 (zeige SMAD2 Proteine)/3 and suppress R-SMAD (zeige SMAD1 Proteine)-dependent transcription. MEKK2 and MEKK3 (zeige MAP3K3 Proteine) play overlapping roles in regulating Th-cell differentiation via TGF-beta (zeige TGFB1 Proteine)

  7. Data show that HDAC4 (zeige HDAC5 Proteine) binds and promotes the deacetylation and activation of a key MAP3 kinase, MEKK2.

  8. Data from experiments with Mekk2(-/-) mice show that MEKK2 may be required for controlling the strength of T cell receptor/CD3 (zeige CD3E Proteine) signaling.

  9. PB1 (zeige GPR97 Proteine) domain mediates the association of MEKK2 and MEKK3 (zeige MAP3K3 Proteine) with MEK5 (zeige MAP2K5 Proteine) and that the respective PB1 (zeige GPR97 Proteine) domains of these kinases are critical for regulation of the ERK5 (zeige MAPK7 Proteine) pathway.

  10. Rap1 (zeige TERF2IP Proteine) and MEKK2 are critical upstream signaling molecules mediating BDNF (zeige BDNF Proteine) stimulation of ERK5 (zeige MAPK7 Proteine) in central nervous system neurons

MAP3K2 Protein Überblick

Protein Überblick

The protein encoded by this gene is a member of serine/threonine protein kinase family. This kinase preferentially activates other kinases involved in the MAP kinase signaling pathway. This kinase has been shown to directly phosphorylate and activate Ikappa B kinases, and thus plays a role in NF-kappa B signaling pathway. This kinase has also been found to bind and activate protein kinase C-related kinase 2, which suggests its involvement in a regulated signaling process.

Alternative names and synonyms associated with MAP3K2

  • mitogen activated protein kinase kinase kinase 2 (Map3k2)
  • mitogen-activated protein kinase kinase kinase 2 (MAP3K2)
  • mitogen-activated protein kinase kinase kinase 2 (Map3k2)
  • 9630061B06Rik Protein
  • AI585793 Protein
  • MEKK2 Protein
  • Mekk2b Protein

Bezeichner auf Proteinebene für MAP3K2

mitogen-activated protein kinase kinase kinase 2 , MAP/ERK kinase kinase 2 , MAPK/ERK kinase kinase 2 , MEK kinase 2 , MEKK 2 , mitogen activated protein kinase kinase kinase 2 , protein kinase MEKK2b

GENE ID SPEZIES
171492 Rattus norvegicus
10746 Homo sapiens
26405 Mus musculus
612902 Canis lupus familiaris
100050628 Equus caballus
504592 Bos taurus
424225 Gallus gallus
100621234 Sus scrofa
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