MAP3K12 Proteine (MAP3K12)

Bezeichnung:
Mitogen-Activated Protein Kinase Kinase Kinase 12 Proteine (MAP3K12)
Auf www.antikoerper-online.de finden Sie aktuell 7 Mitogen-Activated Protein Kinase Kinase Kinase 12 (MAP3K12) Proteine von 5 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen MAP3K12 Antikörper (59) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 71 MAP3K12 Produkte verfügbar.
Synonyme:
Delta1, DKFZp459K2433, DLK, DLK-1, FA1, map3k12, map3k12a, MEKK12, MGC151798, MUK, pG2, PK, Pref-1, PREF1, zgc:77370, ZOG, ZPK, ZPKP1
alle Proteine anzeigen Gen GeneID UniProt
MAP3K12 8788 P80370
MAP3K12 25579 Q63796
MAP3K12 26404 Q60700

Weitere Synonyme anzeigen

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Human Mitogen-Activated Protein Kinase Kinase Kinase 12 (MAP3K12) Interaktionspartner

  1. results demonstrate that miR (zeige MLXIP Proteine)-129-5p inhibits non-small cell lung cancer stemness and chemoresistance through direct targeting of DLK1 (zeige DLK1 Proteine)

  2. A complex defect of DLK1 (zeige DLK1 Proteine) ( approximately 14-kb deletion and 269-bp duplication) was identified in a family with central precocious puberty. This deletion included the 5' untranslated region and the first exon of DLK1 (zeige DLK1 Proteine), including the translational start site. Only family members who inherited the defect from their father have precocious puberty, consistent with the known imprinting of DLK1 (zeige DLK1 Proteine).

  3. Loss of DLK1 (zeige DLK1 Proteine) expression is associated with fetal growth retardation complications of pregnancy.

  4. LZK (zeige MAP3K13 Proteine) cooperates with DLK (zeige DAPK3 Proteine) to promote retinal ganglion cell death in response to axon injury.

  5. In neonatal skin, DLK1 (zeige DLK1 Proteine) exhibited a high degree of monoallelic expression from the paternal allele.

  6. The study evaluated the roles of extracellular soluble DLK1 (zeige DLK1 Proteine), comprising six EGF (zeige EGF Proteine)-like domains and juxtamembrane regions, in human pancreatic cancer MIA (zeige MIA Proteine) PaCa-2 cells in vitro and in vivo. Soluble DLK1 (zeige DLK1 Proteine) exerted antitumor effects not only in cancer cell migration and anchorage-independent cell growth but also in in vivo tumor growth.

  7. Treatment of mice with recombinant human DLK1 (zeige DLK1 Proteine) during pregnancy has significant effects on AT of the offspring. This can be associated with counter-regulatory changes in the Notch1 (zeige NOTCH1 Proteine) signaling cascade.

  8. NOTCH1 (zeige NOTCH1 Proteine) ligand Delta-like 1 (zeige DLL1 Proteine) homolog (DLK1 (zeige DLK1 Proteine)) self interacts

  9. Pref-1 (zeige DLK1 Proteine) induces insulin (zeige INS Proteine) synthesis and secretion via two independent pathways

  10. REVIEW: Regulation of Beta-Cell Function and Mass by the Dual Leucine Zipper Kinase

Mouse (Murine) Mitogen-Activated Protein Kinase Kinase Kinase 12 (MAP3K12) Interaktionspartner

  1. Results provide the first evidence that axon guidance genes are downstream targets of the dual leucine zipper kinase (DLK) signaling pathway, which through their regulation probably modulates neuronal cell development, structure and function.

  2. LZK (zeige MAP3K13 Proteine) cooperates with DLK (zeige DAPK3 Proteine) to promote retinal ganglion cell death in response to axon injury.

  3. the prevention of the nuclear localization of DLK (zeige DAPK3 Proteine) as induced by prediabetic signals with consecutive suppression of beta-cell apoptosis might constitute a novel target in the therapy of diabetes mellitus

  4. Data assesses DLK's role in axons of adult, injured CNS neurons in vivo and shows that DLK (zeige DAPK3 Proteine) does not appear to have a critical function in axonal degeneration; function appears restricted to soma

  5. This study provides compelling evidence for the pivotal roles of the ZPK/DLK and MKK4/MAP2K4 (zeige MAP2K4 Proteine)-dependent mechanism in axotomy-induced motoneuron death in neonates

  6. DLK (zeige DAPK3 Proteine)-inducible knockouts displayed a modest increase in basal synaptic transmission but had an attenuation of the JNK/c-Jun stress response pathway activation and significantly reduced neuronal degeneration after kainic acid-induced seizures.

  7. Abundance of DLK (zeige DAPK3 Proteine) in turn controlled the levels of downstream JNK (zeige MAPK8 Proteine) signaling and apoptosis.

  8. DLK (zeige DAPK3 Proteine) is required for RGC JNK (zeige MAPK8 Proteine) activation and cell death in a rodent model of optic neuropathy

  9. The cell intrinsic factors that determine whether a neuron regenerates or undergoes apoptosis in response to axonal injury are not well defined. DLK (zeige DAPK3 Proteine) is an essential upstream mediator of both of these divergent outcomes in the same cell type.

  10. These data demonstrate that DLK (zeige DAPK3 Proteine) enhances regeneration by promoting a retrograde injury signal that is required for the activation of the neuronal proregenerative program.

MAP3K12 Protein Überblick

Protein Überblick

This gene encodes a member of the serine/threonine protein kinase family. This kinase contains a leucine-zipper domain and is predominately expressed in neuronal cells. The phosphorylation state of this kinase in synaptic terminals was shown to be regulated by membrane depolarization via calcineurin. This kinase forms heterodimers with leucine zipper containing transcription factors, such as cAMP responsive element binding protein (CREB) and MYC, and thus may play a regulatory role in PKA or retinoic acid induced neuronal differentiation. Alternatively spliced transcript variants encoding different proteins have been described.

Alternative names and synonyms associated with MAP3K12

  • mitogen-activated protein kinase kinase kinase 12 (map3k12)
  • mitogen-activated protein kinase kinase kinase 12 (MAP3K12)
  • mitogen-activated protein kinase kinase kinase 12 (map3k12-a)
  • delta-like 1 homolog (Drosophila) (DLK1)
  • mitogen activated protein kinase kinase kinase 12 (Map3k12)
  • mitogen-activated protein kinase kinase kinase 12 (Map3k12)
  • Delta1 Protein
  • DKFZp459K2433 Protein
  • DLK Protein
  • DLK-1 Protein
  • FA1 Protein
  • map3k12 Protein
  • map3k12a Protein
  • MEKK12 Protein
  • MGC151798 Protein
  • MUK Protein
  • pG2 Protein
  • PK Protein
  • Pref-1 Protein
  • PREF1 Protein
  • zgc:77370 Protein
  • ZOG Protein
  • ZPK Protein
  • ZPKP1 Protein

Bezeichner auf Proteinebene für MAP3K12

mitogen-activated protein kinase kinase kinase 12 , mitogen activated protein kinase kinase kinase 12 type A , fetal antigen 1 , preadipocyte factor 1 , protein delta homolog 1 , secredeltin , MAPK-upstream kinase , Mitogen activated protein kinase 12 (Zipper (leucine) protein kinase) , Zipper (leucine) protein kinase , dual leucine zipper bearing kinase , dual leucine zipper kinase , leucine-zipper protein kinase , mixed lineage kinase , dual leucine zipper kinase DLK , leucine zipper protein kinase , protein kinase MUK , mitogen activated protein kinase kinase kinase 12 , zipper (leucine) protein kinase

GENE ID SPEZIES
404626 Danio rerio
451940 Pan troglodytes
505427 Bos taurus
607170 Canis lupus familiaris
703059 Macaca mulatta
100064002 Equus caballus
100113430 Xenopus laevis
100172208 Pongo abelii
100358158 Oryctolagus cuniculus
100408788 Callithrix jacchus
100469942 Ailuropoda melanoleuca
100517714 Sus scrofa
8788 Homo sapiens
25579 Rattus norvegicus
7786 Homo sapiens
26404 Mus musculus
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