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The study identifies MKK3 as a negative regulator of mitochondrial function and inflammatory responses to cigarette smoke and suggests that MKK3 could be a therapeutic target.
MEK2 (zeige MAP2K2 ELISA Kits) was essential for the phosphorylation of MKK3/MKK6 (zeige MAP2K6 ELISA Kits) and p38 MAPK (zeige MAPK14 ELISA Kits) that directly impacted on cyclin D1 (zeige CCND1 ELISA Kits) expression.
High MKK3 expression is associated with lung cancer.
The results revealed upregulation of MEK3, as well as phosphorylated MEK3 and phosphorylated p38 MAPK (zeige MAPK14 ELISA Kits), in CMM patients. These results provide a "fingerprint" for mechanistic studies of CMM in the future and highlight the importance of MEK3-p38 MAPK (zeige MAPK14 ELISA Kits) activation in CMM.
miR (zeige MLXIP ELISA Kits)-21 targets MKK3 in vivo and in vitro, inhibiting the downstream factors IL-6 (zeige IL6 ELISA Kits) and TNF-alpha (zeige TNF ELISA Kits), in ischemia pretreatment protection from ischemia-reperfusion induced kidney injury.
MKK3 overexpression upregulated the cyclin-dependent kinase (zeige CDK1 ELISA Kits) inhibitors, p16 INK4A and p15 INK4B (zeige CDKN2B ELISA Kits) in hepatocellular carcinoma cells was Bim1, was downregulated following MKK3 overexpression.
Our results suggest that asthma is associated with MKK3 over-expression in CD8 (zeige CD8A ELISA Kits)+ cells; we have also demonstrated that MKK3 may be critical for airway neutrophilia
MicroRNA-21 promotes hepatocellular carcinoma HepG2 cell proliferation through repression of mitogen-activated protein kinase-kinase 3.
study detected higher MKK3 activation in isolated peripheral blood mononuclear cells from septic patients compared with nonseptic controls
study concludes MAP2K3 is a reproducible obesity locus that may affect body weight via complex mechanisms involving appetite regulation and hypothalamic inflammation
The study identifies MKK3 as a negative regulator of mitochondrial function and inflammatory responses to cigarette smoke.
MAP2K6 (zeige MAP2K6 ELISA Kits) functions in mouse testis determination, via positive effects on Sry (zeige SRY ELISA Kits), and a minor role for MAP2K3.
ATF3 (zeige ATF3 ELISA Kits) upregulation in cardiac fibroblasts in response to hypertensive stimuli protects the heart by suppressing Map2K3 expression and subsequent p38 (zeige CRK ELISA Kits)-transforming growth factor-beta signaling.
miR (zeige MLXIP ELISA Kits)-21a-5p inhibited BPA (zeige DST ELISA Kits) induced adipocyte differentiation by targeting map2k3 through MKK3/p38/MAPK (zeige MAPK14 ELISA Kits) in 3T3-L1 cells
this study demonstrates that MKK3 influences mitochondrial quality by affecting the expression of mitochondrial proteins, including TCA cycle enzymes, and mitophagy, which consequently regulates the inflammatory response.
Exendin-4 treatment improves cardiac function, attenuates cardiac remodeling, and promotes angiogenesis in the infarcted myocardium through MKK3 and Akt-1 (zeige AKT1 ELISA Kits) pathway.
MKK3 and MKK6 (zeige MAP2K6 ELISA Kits) differentially regulate bone loss due to estrogen withdrawal. MKK3 directly mediates osteoclastogenesis while MKK6 (zeige MAP2K6 ELISA Kits) likely contributes to pro-inflammatory cytokine production that promotes osteoclast formation.
results designate MKK3 as a novel, positive regulator of SCF (zeige KITLG ELISA Kits)-induced mast cell proliferation and a critical signaling protein for AP-1 (zeige JUN ELISA Kits)-dependent IL-6 (zeige IL6 ELISA Kits) production
The protein encoded by this gene is a dual specificity protein kinase that belongs to the MAP kinase kinase family. This kinase is activated by mitogenic and environmental stress, and participates in the MAP kinase-mediated signaling cascade. It phosphorylates and thus activates MAPK14/p38-MAPK. This kinase can be activated by insulin, and is necessary for the expression of glucose transporter. Expression of RAS oncogene is found to result in the accumulation of the active form of this kinase, which thus leads to the constitutive activation of MAPK14, and confers oncogenic transformation of primary cells. The inhibition of this kinase is involved in the pathogenesis of Yersina pseudotuberculosis. Multiple alternatively spliced transcript variants that encode distinct isoforms have been reported for this gene.
MAP kinase kinase 3
, MAPK/ERK kinase 3
, MAPKK 3
, MEK 3
, SAPK kinase 2
, dual specificity mitogen-activated protein kinase kinase 3
, stress-activated protein kinase kinase 2
, mitogen activated protein kinase kinase 3
, protein kinase, mitogen-activated, kinase 3
, MAP kinase kinase 6
, MAPKK 6
, dual specificity mitogen-activated protein kinase kinase 6
, mitogen-activated protein kinase kinase 3