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High MEK1 expression is associated with infant acute lymphoblastic leukemia.
Data show that combined therapy using HER2 (zeige ERBB2 Proteine) inhibitor and BRAF (zeige BRAF Proteine)/MEK inhibitor presented more significant redifferentiation effect on papillary thyroid cancer cells harboring BRAFV600E than BRAF (zeige BRAF Proteine)/MEK inhibitor alone.
MEK1 is constitutively and mainly phosphorylated at the Thr (zeige TRH Proteine)-292, Ser (zeige SIGLEC1 Proteine)-298, Thr (zeige TRH Proteine)-386, and Thr (zeige TRH Proteine)-388 residues in vivo, and combinations of phosphorylations at these four residues produce at least six phosphorylated variants of MEK1. The phosphorylation statuses of Thr (zeige TRH Proteine)-292, Ser (zeige SIGLEC1 Proteine)-298, Thr (zeige TRH Proteine)-386, and Thr (zeige TRH Proteine)-388 residues vary widely during activation and deactivation of the MAPK (zeige MAPK1 Proteine) pathway.
TNFRSF14 (zeige TNFRSF14 Proteine) and MAP2K1 mutations are the most frequent genetic alterations found in pediatric-type follicular lymphoma (PTFL) and occur independently in most cases, suggesting that both mutations might play an important role in PTFL lymphomagenesis.
There was no statistically significant association between BRAF (zeige BRAF Proteine) or MAP2K1 mutation and anatomic site, unifocal versus multifocal presentation, or clinical outcome in Langerhans cell histiocytosis.
High MEK1 expression is associated with inflammation.
Lgr4 (zeige LGR4 Proteine) is a critical positive factor for skin tumorigenesis by mediating the activation of MEK1/ERK1/2 and Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) pathways.
somatic mutations in MAP2K1 are a common cause of extracranial arteriovenous malformation
MEK1 mutation is associated with central nervous system metastases of non-small cell lung cancer.
The MAP2K1 mutation analysis of three hairy cell leukemia cases, one hairy cell leukemia-variant case, and three splenic marginal zone lymphoma cases revealed negative results.
fluid shear stress induces autocrine TGF-beta (zeige TGFB1 Proteine)/ALK5 (zeige TGFBR1 Proteine)-induced target gene expression in renal epithelial cells, which is partially restrained by MEK1/2-mediated signaling.
FGF2 (zeige FGF2 Proteine) is an extracellular inducer of COUP-TFII (zeige NR2F2 Proteine) expression and may suppress the osteogenic potential of mesenchymal cells by inducing COUP-TFII (zeige NR2F2 Proteine) expression prior to the onset of osteogenic differentiation
REDD1 (zeige DDIT4 Proteine) is required for normal insulin (zeige INS Proteine)-stimulated signaling, and a subtle balance exists between MEK1/2, REDD1 (zeige DDIT4 Proteine), and mTOR (zeige FRAP1 Proteine)
blood glucose levels are reduced by suppression of MEK1 expression in the liver of db/db (zeige LEPR Proteine) mice
MEK1 and MEK2 (zeige MAP2K2 Proteine) can substitute for each other but a minimum amount of MEK (zeige MDK Proteine) is critical for placenta development and embryo survival
Aberrant phosphorylation of AKT (zeige AKT1 Proteine) and MEK (zeige MDK Proteine) signalling pathways was identified in cells carrying mutant huntingtin (zeige HTT Proteine).
An essential function for MEK1 in macrophages in regulating the ERK1/2 and STAT4 (zeige STAT4 Proteine) pathways in response to TLR4 (zeige TLR4 Proteine) activation.
Nuclear enrichment of MEK1 physically sequesters peroxisome proliferator-activated receptor gamma (PPARgamma (zeige PPARG Proteine)), inhibiting adipogenesis and disrupting ERK (zeige EPHB2 Proteine) signaling.
MEK1 is inhibited by phosphorylation at Thr (zeige TRH Proteine)-292/286 by Cdk5 (zeige CDK5 Proteine), ERK (zeige EPHB2 Proteine), and Cdk1 (zeige CDK1 Proteine).
in FGFR1 (zeige FGFR1 Proteine) signalling JNK1 (zeige MAPK8 Proteine) phosphorylation depends on ERK2 (zeige MAPK1 Proteine)
The data demonstrate that ERK (zeige MAPK1 Proteine) phosphorylation of UBF prevents DNA bending by its first two HMG (zeige SSRP1 Proteine) boxes, leading to a cooperative unfolding of the enhancesome
We propose that Erk2 MAP kinase (zeige MAPK1 Proteine) phosphorylation of Vg1RBP (zeige IGF2BP3 Proteine) regulates the protein:protein-mediated association of Vg1 mRNP with the cytoskeleton and/or ER.
Extracellular signal-regulated kinase (ERK (zeige MAPK1 Proteine)) pathway plays a role in dedifferentiation of rabbit articular chondrocytes.
KSR (zeige KSR1 Proteine) interacts with a regulatory Raf (zeige RAF1 Proteine) molecule in cis (zeige CISH Proteine) to induce a conformational switch of MEK, facilitating MEK's phosphorylation by a separate catalytic Raf (zeige RAF1 Proteine) molecule in trans
20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism.
Data indicate that MEKK2 (zeige MAP3K2 Proteine) is required for the mekk1 (zeige MAP3K1 Proteine), mkk1 mkk2 (zeige MAP2K2 Proteine), and mpk4 (zeige MAPK4 Proteine) autoimmune phenotypes.
Data suggest that the MEKK1 (zeige MAP3K1 Proteine)-MKK1/MKK2 (zeige MAP2K2 Proteine)-MPK4 (zeige MAPK4 Proteine) kinase cascade negatively regulates MEKK2 (zeige MAP3K2 Proteine) and activation of MEKK2 (zeige MAP3K2 Proteine) triggers SUMM2-mediated immune responses.
miR (zeige MYLIP Proteine)-1826 plays an important role as tumor suppressor via CTNNB1 (zeige CTNNB1 Proteine)/MEK1/VEGFC (zeige VEGFC Proteine) downregulation in bladder cancer.
ETS1 (zeige ETS1 Proteine) is probably mediating high CIP2A (zeige KIAA1524 Proteine) expression in human cancers with increased EGFR (zeige EGFR Proteine)-MEK1/2-ERK (zeige MAPK1 Proteine) pathway activity
An analysis of the interation of MEKK1 (zeige MAP3K1 Proteine) and MEK1 in response to wounding stress in A. thaliana seedlings is presented.
This study demonstrated that the MKK1 signalling pathway modulates the expression of genes responding to elicitors and plays an important role in pathogen defence.
These results suggest that the formation of SUMO-1 (zeige SUMO1 Proteine) foci is regulated by the MEK-ERK (zeige MAPK1 Proteine) pathway and may induce apoptosis.
AtMEK1 is a crucial mediator in plant stress signal transduction.
double loss-of-function mutant (mkk1/2) of MKK1 and MKK2 (zeige MAP2K2 Proteine) is shown to have marked phenotypes in development and disease resistance similar to those of the single mekk1 (zeige MAP3K1 Proteine) and mpk4 (zeige MAPK4 Proteine) mutants
Activation of MPK4 (zeige MAPK4 Proteine) by flg22 is impaired in the mkk1 mkk2 (zeige MAP2K2 Proteine) double mutants, suggesting that MKK1 and MKK2 (zeige MAP2K2 Proteine) function together with MPK4 (zeige MAPK4 Proteine) and MEKK1 (zeige MAP3K1 Proteine) in a MAP kinase (zeige MAPK1 Proteine) cascade to negatively regulate innate immune responses in plants.
The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development.
ERK activator kinase 1
, MAP kinase kinase 1
, MAP kinase/Erk kinase 1
, MAPK/ERK kinase 1
, MAPKK 1
, dual specificity mitogen-activated protein kinase kinase 1
, mitogen-activated protein kinase kinase 1
, MEK 1
, protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1)
, dual specificity mitogen activated protein kinase kinase 1
, mitogen activated protein kinase kinase 1
, protein kinase, mitogen activated, kinase 1, p45
, MAP kinase kinase or Erk Kinase, Dual specificity mitogen-activated protein kinase kinase, involved in ras mediated vulval induction, LEThal LET-537 (42.8 kD) (mek-2)