MAP2K1 Proteine (MAP2K1)

Bezeichnung:
Mitogen-Activated Protein Kinase Kinase 1 Proteine (MAP2K1)
Auf www.antikoerper-online.de finden Sie aktuell 22 Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1) Proteine von 9 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen MAP2K1 Antikörper (619) und MAP2K1 Kits (31) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 711 MAP2K1 Produkte verfügbar.
Synonyme:
ATMEK1, CFC3, F20B18.180, F20B18_180, MAP kinase/ ERK kinase 1, MAPKK1, MEK, mek-2, MEK1, MEKK1, MITOGEN ACTIVATED PROTEIN KINASE KINASE, MITOGEN ACTIVATED PROTEIN KINASE KINASE 1, MKK1, NMAPKK, Prkmk1, si:ch211-242m18.2, wu:fj56a12, wu:fj61b01, zgc:56557
alle Proteine anzeigen Gen GeneID UniProt
MAP2K1 170851 Q01986
MAP2K1 5604 Q02750
MAP2K1 26395 P31938

Weitere Synonyme anzeigen

MAP2K1 Proteine (MAP2K1) nach Spezies

Wählen Sie die gewünschte Spezies

Am meisten referenzierte MAP2K1 Proteine

  1. Mouse (Murine) MAP2K1 Protein expressed in Baculovirus infected Insect Cells - ABIN3216428 : Duesbery, Webb, Leppla, Gordon, Klimpel, Copeland, Ahn, Oskarsson, Fukasawa, Paull, Vande Woude: Proteolytic inactivation of MAP-kinase-kinase by anthrax lethal factor. in Science (New York, N.Y.) 1998 (PubMed)
    Zeige alle 4 Referenzen für 3216428

Weitere Proteine zu MAP2K1 Interaktionspartnern

Human Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1) Interaktionspartner

  1. MEK1 is constitutively and mainly phosphorylated at the Thr (zeige TRH Proteine)-292, Ser (zeige SIGLEC1 Proteine)-298, Thr (zeige TRH Proteine)-386, and Thr (zeige TRH Proteine)-388 residues in vivo, and combinations of phosphorylations at these four residues produce at least six phosphorylated variants of MEK1. The phosphorylation statuses of Thr (zeige TRH Proteine)-292, Ser (zeige SIGLEC1 Proteine)-298, Thr (zeige TRH Proteine)-386, and Thr (zeige TRH Proteine)-388 residues vary widely during activation and deactivation of the MAPK (zeige MAPK1 Proteine) pathway.

  2. TNFRSF14 (zeige TNFRSF14 Proteine) and MAP2K1 mutations are the most frequent genetic alterations found in pediatric-type follicular lymphoma (PTFL) and occur independently in most cases, suggesting that both mutations might play an important role in PTFL lymphomagenesis.

  3. There was no statistically significant association between BRAF (zeige BRAF Proteine) or MAP2K1 mutation and anatomic site, unifocal versus multifocal presentation, or clinical outcome in Langerhans cell histiocytosis.

  4. High MEK1 expression is associated with inflammation.

  5. Lgr4 (zeige LGR4 Proteine) is a critical positive factor for skin tumorigenesis by mediating the activation of MEK1/ERK1/2 and Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) pathways.

  6. somatic mutations in MAP2K1 are a common cause of extracranial arteriovenous malformation

  7. MEK1 mutation is associated with central nervous system metastases of non-small cell lung cancer.

  8. The MAP2K1 mutation analysis of three hairy cell leukemia cases, one hairy cell leukemia-variant case, and three splenic marginal zone lymphoma cases revealed negative results.

  9. Data show that mitogen-activated protein kinase (zeige MAPK1 Proteine) kinases MEK1/2 inhibitor pimasertib (MEKI) sensitized the cells to apoptosis through its ability to promote a G1 cell cycle arrest.

  10. the purpose of this paper was to investigate MAPK (zeige MAPK1 Proteine) downstream signalling molecules in Natural killer cell phenotypes from Chronic Fatigue Syndrome/Myalgic Encephalomyelitis patients.

Mouse (Murine) Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1) Interaktionspartner

  1. Lgr4 (zeige LGR4 Proteine) is a critical positive factor for skin tumorigenesis by mediating the activation of MEK1/ERK1/2 and Wnt (zeige WNT2 Proteine)/beta-catenin (zeige CTNNB1 Proteine) pathways.

  2. FGF2 (zeige FGF2 Proteine) is an extracellular inducer of COUP-TFII (zeige NR2F2 Proteine) expression and may suppress the osteogenic potential of mesenchymal cells by inducing COUP-TFII (zeige NR2F2 Proteine) expression prior to the onset of osteogenic differentiation

  3. REDD1 (zeige DDIT4 Proteine) is required for normal insulin (zeige INS Proteine)-stimulated signaling, and a subtle balance exists between MEK1/2, REDD1 (zeige DDIT4 Proteine), and mTOR (zeige FRAP1 Proteine)

  4. blood glucose levels are reduced by suppression of MEK1 expression in the liver of db/db (zeige LEPR Proteine) mice

  5. MEK1 and MEK2 (zeige MAP2K2 Proteine) can substitute for each other but a minimum amount of MEK (zeige MDK Proteine) is critical for placenta development and embryo survival

  6. Aberrant phosphorylation of AKT (zeige AKT1 Proteine) and MEK (zeige MDK Proteine) signalling pathways was identified in cells carrying mutant huntingtin (zeige HTT Proteine).

  7. An essential function for MEK1 in macrophages in regulating the ERK1/2 and STAT4 (zeige STAT4 Proteine) pathways in response to TLR4 (zeige TLR4 Proteine) activation.

  8. Nuclear enrichment of MEK1 physically sequesters peroxisome proliferator-activated receptor gamma (PPARgamma (zeige PPARG Proteine)), inhibiting adipogenesis and disrupting ERK (zeige EPHB2 Proteine) signaling.

  9. MEK1 is inhibited by phosphorylation at Thr (zeige TRH Proteine)-292/286 by Cdk5 (zeige CDK5 Proteine), ERK (zeige EPHB2 Proteine), and Cdk1 (zeige CDK1 Proteine).

  10. The effect of Akt1 (zeige AKT1 Proteine) and Mek1 on extracellular matrix synthesis was reconciled through the activation of p70 S6-kinase (zeige PRKACB Proteine).

Xenopus laevis Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1) Interaktionspartner

  1. in FGFR1 (zeige FGFR1 Proteine) signalling JNK1 (zeige MAPK8 Proteine) phosphorylation depends on ERK2 (zeige MAPK1 Proteine)

  2. The data demonstrate that ERK (zeige MAPK1 Proteine) phosphorylation of UBF prevents DNA bending by its first two HMG (zeige SSRP1 Proteine) boxes, leading to a cooperative unfolding of the enhancesome

  3. We propose that Erk2 MAP kinase (zeige MAPK1 Proteine) phosphorylation of Vg1RBP (zeige IGF2BP3 Proteine) regulates the protein:protein-mediated association of Vg1 mRNP with the cytoskeleton and/or ER.

Rabbit Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1) Interaktionspartner

  1. Extracellular signal-regulated kinase (ERK (zeige MAPK1 Proteine)) pathway plays a role in dedifferentiation of rabbit articular chondrocytes.

  2. KSR (zeige KSR1 Proteine) interacts with a regulatory Raf (zeige RAF1 Proteine) molecule in cis (zeige CISH Proteine) to induce a conformational switch of MEK, facilitating MEK's phosphorylation by a separate catalytic Raf (zeige RAF1 Proteine) molecule in trans

Pig (Porcine) Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1) Interaktionspartner

  1. 20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism.

Arabidopsis thaliana Mitogen-Activated Protein Kinase Kinase 1 (MAP2K1) Interaktionspartner

  1. Data indicate that MEKK2 (zeige MAP3K2 Proteine) is required for the mekk1 (zeige MAP3K1 Proteine), mkk1 mkk2 (zeige MAP2K2 Proteine), and mpk4 (zeige MAPK4 Proteine) autoimmune phenotypes.

  2. Data suggest that the MEKK1 (zeige MAP3K1 Proteine)-MKK1/MKK2 (zeige MAP2K2 Proteine)-MPK4 (zeige MAPK4 Proteine) kinase cascade negatively regulates MEKK2 (zeige MAP3K2 Proteine) and activation of MEKK2 (zeige MAP3K2 Proteine) triggers SUMM2-mediated immune responses.

  3. miR (zeige MYLIP Proteine)-1826 plays an important role as tumor suppressor via CTNNB1 (zeige CTNNB1 Proteine)/MEK1/VEGFC (zeige VEGFC Proteine) downregulation in bladder cancer.

  4. ETS1 (zeige ETS1 Proteine) is probably mediating high CIP2A (zeige KIAA1524 Proteine) expression in human cancers with increased EGFR (zeige EGFR Proteine)-MEK1/2-ERK (zeige MAPK1 Proteine) pathway activity

  5. An analysis of the interation of MEKK1 (zeige MAP3K1 Proteine) and MEK1 in response to wounding stress in A. thaliana seedlings is presented.

  6. This study demonstrated that the MKK1 signalling pathway modulates the expression of genes responding to elicitors and plays an important role in pathogen defence.

  7. These results suggest that the formation of SUMO-1 (zeige SUMO1 Proteine) foci is regulated by the MEK-ERK (zeige MAPK1 Proteine) pathway and may induce apoptosis.

  8. AtMEK1 is a crucial mediator in plant stress signal transduction.

  9. double loss-of-function mutant (mkk1/2) of MKK1 and MKK2 (zeige MAP2K2 Proteine) is shown to have marked phenotypes in development and disease resistance similar to those of the single mekk1 (zeige MAP3K1 Proteine) and mpk4 (zeige MAPK4 Proteine) mutants

  10. Activation of MPK4 (zeige MAPK4 Proteine) by flg22 is impaired in the mkk1 mkk2 (zeige MAP2K2 Proteine) double mutants, suggesting that MKK1 and MKK2 (zeige MAP2K2 Proteine) function together with MPK4 (zeige MAPK4 Proteine) and MEKK1 (zeige MAP3K1 Proteine) in a MAP kinase (zeige MAPK1 Proteine) cascade to negatively regulate innate immune responses in plants.

MAP2K1 Protein Überblick

Protein Überblick

The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development.

Alternative names and synonyms associated with MAP2K1

  • mitogen activated protein kinase kinase 1 (Map2k1)
  • mitogen-activated protein kinase kinase 1 (MAP2K1)
  • mitogen-activated protein kinase kinase 1 (Map2k1)
  • mitogen-activated protein kinase kinase 1 (map2k1)
  • mitogen-activated protein kinase kinase 1 (MEK1)
  • ATMEK1 Protein
  • CFC3 Protein
  • F20B18.180 Protein
  • F20B18_180 Protein
  • MAP kinase/ ERK kinase 1 Protein
  • MAPKK1 Protein
  • MEK Protein
  • mek-2 Protein
  • MEK1 Protein
  • MEKK1 Protein
  • MITOGEN ACTIVATED PROTEIN KINASE KINASE Protein
  • MITOGEN ACTIVATED PROTEIN KINASE KINASE 1 Protein
  • MKK1 Protein
  • NMAPKK Protein
  • Prkmk1 Protein
  • si:ch211-242m18.2 Protein
  • wu:fj56a12 Protein
  • wu:fj61b01 Protein
  • zgc:56557 Protein

Bezeichner auf Proteinebene für MAP2K1

ERK activator kinase 1 , MAP kinase kinase 1 , MAP kinase/Erk kinase 1 , MAPK/ERK kinase 1 , MAPKK 1 , dual specificity mitogen-activated protein kinase kinase 1 , mitogen-activated protein kinase kinase 1 , MEK 1 , protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1) , dual specificity mitogen activated protein kinase kinase 1 , mitogen activated protein kinase kinase 1 , protein kinase, mitogen activated, kinase 1, p45 , MAP kinase kinase or Erk Kinase, Dual specificity mitogen-activated protein kinase kinase, involved in ras mediated vulval induction, LEThal LET-537 (42.8 kD) (mek-2) , MEK1

GENE ID SPEZIES
170851 Rattus norvegicus
5604 Homo sapiens
478347 Canis lupus familiaris
26395 Mus musculus
379991 Xenopus laevis
415549 Gallus gallus
533199 Bos taurus
406728 Danio rerio
100009316 Oryctolagus cuniculus
100233191 Sus scrofa
828713 Arabidopsis thaliana
450188 Pan troglodytes
Ausgewählte Anbieter für MAP2K1 Proteine (MAP2K1)
Haben Sie etwas anderes gesucht?