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Rat (Rattus) MAP2K1 ELISA Kit für Sandwich ELISA - ABIN433773
Du, Wang, Wang: Role of RhoA/MERK1/ERK1/2/iNOS signaling in ocular ischemic syndrome. in Graefe's archive for clinical and experimental ophthalmology 2016
Human MAP2K1 ELISA Kit für Sandwich ELISA - ABIN419235
El-Ansary, Hassan, Qasem, Das: Identification of Biomarkers of Impaired Sensory Profiles among Autistic Patients. in PLoS ONE 2016
High MEK1 expression is associated with neuroblastoma (zeige ARHGEF16 ELISA Kits).
mutations in MAP2K1, which are frequently associated with neurological complications and intellectual disability, can be associated with a milder clinical and neurocognitive profile more typical of individuals with Noonan syndrome. Variability of expression may arise from a complex interplay between RAS/MAPK (zeige MAPK1 ELISA Kits) pathway genotype, epigenetics, medical and obstetric factors, and environmental influences.
High MEK1 expression is associated with infant acute lymphoblastic leukemia.
Data show that combined therapy using HER2 (zeige ERBB2 ELISA Kits) inhibitor and BRAF (zeige BRAF ELISA Kits)/MEK inhibitor presented more significant redifferentiation effect on papillary thyroid cancer cells harboring BRAFV600E than BRAF (zeige BRAF ELISA Kits)/MEK inhibitor alone.
MEK1 is constitutively and mainly phosphorylated at the Thr (zeige TRH ELISA Kits)-292, Ser (zeige SIGLEC1 ELISA Kits)-298, Thr (zeige TRH ELISA Kits)-386, and Thr (zeige TRH ELISA Kits)-388 residues in vivo, and combinations of phosphorylations at these four residues produce at least six phosphorylated variants of MEK1. The phosphorylation statuses of Thr (zeige TRH ELISA Kits)-292, Ser (zeige SIGLEC1 ELISA Kits)-298, Thr (zeige TRH ELISA Kits)-386, and Thr (zeige TRH ELISA Kits)-388 residues vary widely during activation and deactivation of the MAPK (zeige MAPK1 ELISA Kits) pathway.
TNFRSF14 (zeige TNFRSF14 ELISA Kits) and MAP2K1 mutations are the most frequent genetic alterations found in pediatric-type follicular lymphoma (PTFL) and occur independently in most cases, suggesting that both mutations might play an important role in PTFL lymphomagenesis.
There was no statistically significant association between BRAF (zeige BRAF ELISA Kits) or MAP2K1 mutation and anatomic site, unifocal versus multifocal presentation, or clinical outcome in Langerhans cell histiocytosis.
High MEK1 expression is associated with inflammation.
Lgr4 (zeige LGR4 ELISA Kits) is a critical positive factor for skin tumorigenesis by mediating the activation of MEK1/ERK1/2 (zeige MAPK1/3 ELISA Kits) and Wnt (zeige WNT2 ELISA Kits)/beta-catenin (zeige CTNNB1 ELISA Kits) pathways.
somatic mutations in MAP2K1 are a common cause of extracranial arteriovenous malformation
High MEK1 expression is associated with Melanoma Metastasis.
cartilage-specific inactivation of miR322 in mice linked the loss of miR (zeige MLXIP ELISA Kits)-322 to decreased MEK1 levels and to increased RAF (zeige RAF1 ELISA Kits)/MEK (zeige MDK ELISA Kits)/ERK (zeige EPHB2 ELISA Kits) pathway activation.
fluid shear stress induces autocrine TGF-beta (zeige TGFB1 ELISA Kits)/ALK5 (zeige TGFBR1 ELISA Kits)-induced target gene expression in renal epithelial cells, which is partially restrained by MEK1/2-mediated signaling.
FGF2 (zeige FGF2 ELISA Kits) is an extracellular inducer of COUP-TFII (zeige NR2F2 ELISA Kits) expression and may suppress the osteogenic potential of mesenchymal cells by inducing COUP-TFII (zeige NR2F2 ELISA Kits) expression prior to the onset of osteogenic differentiation
REDD1 (zeige DDIT4 ELISA Kits) is required for normal insulin (zeige INS ELISA Kits)-stimulated signaling, and a subtle balance exists between MEK1/2, REDD1 (zeige DDIT4 ELISA Kits), and mTOR (zeige FRAP1 ELISA Kits)
blood glucose levels are reduced by suppression of MEK1 expression in the liver of db/db (zeige LEPR ELISA Kits) mice
MEK1 and MEK2 (zeige MAP2K2 ELISA Kits) can substitute for each other but a minimum amount of MEK (zeige MDK ELISA Kits) is critical for placenta development and embryo survival
Aberrant phosphorylation of AKT (zeige AKT1 ELISA Kits) and MEK (zeige MDK ELISA Kits) signalling pathways was identified in cells carrying mutant huntingtin (zeige HTT ELISA Kits).
An essential function for MEK1 in macrophages in regulating the ERK1/2 (zeige MAPK1/3 ELISA Kits) and STAT4 (zeige STAT4 ELISA Kits) pathways in response to TLR4 (zeige TLR4 ELISA Kits) activation.
in FGFR1 (zeige FGFR1 ELISA Kits) signalling JNK1 (zeige MAPK8 ELISA Kits) phosphorylation depends on ERK2 (zeige MAPK1 ELISA Kits)
The data demonstrate that ERK (zeige MAPK1 ELISA Kits) phosphorylation of UBF prevents DNA bending by its first two HMG (zeige SSRP1 ELISA Kits) boxes, leading to a cooperative unfolding of the enhancesome
We propose that Erk2 MAP kinase (zeige MAPK1 ELISA Kits) phosphorylation of Vg1RBP (zeige IGF2BP3 ELISA Kits) regulates the protein:protein-mediated association of Vg1 mRNP with the cytoskeleton and/or ER.
Extracellular signal-regulated kinase (ERK (zeige MAPK1 ELISA Kits)) pathway plays a role in dedifferentiation of rabbit articular chondrocytes.
KSR (zeige KSR1 ELISA Kits) interacts with a regulatory Raf (zeige RAF1 ELISA Kits) molecule in cis (zeige CISH ELISA Kits) to induce a conformational switch of MEK, facilitating MEK's phosphorylation by a separate catalytic Raf (zeige RAF1 ELISA Kits) molecule in trans
20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism.
Data indicate that MEKK2 (zeige MAP3K2 ELISA Kits) is required for the mekk1 (zeige MAP3K1 ELISA Kits), mkk1 mkk2 (zeige MAP2K2 ELISA Kits), and mpk4 (zeige MAPK4 ELISA Kits) autoimmune phenotypes.
Data suggest that the MEKK1 (zeige MAP3K1 ELISA Kits)-MKK1/MKK2 (zeige MAP2K2 ELISA Kits)-MPK4 (zeige MAPK4 ELISA Kits) kinase cascade negatively regulates MEKK2 (zeige MAP3K2 ELISA Kits) and activation of MEKK2 (zeige MAP3K2 ELISA Kits) triggers SUMM2-mediated immune responses.
miR (zeige MYLIP ELISA Kits)-1826 plays an important role as tumor suppressor via CTNNB1 (zeige CTNNB1 ELISA Kits)/MEK1/VEGFC (zeige VEGFC ELISA Kits) downregulation in bladder cancer.
ETS1 (zeige ETS1 ELISA Kits) is probably mediating high CIP2A (zeige KIAA1524 ELISA Kits) expression in human cancers with increased EGFR (zeige EGFR ELISA Kits)-MEK1/2-ERK (zeige MAPK1 ELISA Kits) pathway activity
An analysis of the interation of MEKK1 (zeige MAP3K1 ELISA Kits) and MEK1 in response to wounding stress in A. thaliana seedlings is presented.
This study demonstrated that the MKK1 signalling pathway modulates the expression of genes responding to elicitors and plays an important role in pathogen defence.
These results suggest that the formation of SUMO-1 (zeige SUMO1 ELISA Kits) foci is regulated by the MEK-ERK (zeige MAPK1 ELISA Kits) pathway and may induce apoptosis.
AtMEK1 is a crucial mediator in plant stress signal transduction.
double loss-of-function mutant (mkk1/2) of MKK1 and MKK2 (zeige MAP2K2 ELISA Kits) is shown to have marked phenotypes in development and disease resistance similar to those of the single mekk1 (zeige MAP3K1 ELISA Kits) and mpk4 (zeige MAPK4 ELISA Kits) mutants
Activation of MPK4 (zeige MAPK4 ELISA Kits) by flg22 is impaired in the mkk1 mkk2 (zeige MAP2K2 ELISA Kits) double mutants, suggesting that MKK1 and MKK2 (zeige MAP2K2 ELISA Kits) function together with MPK4 (zeige MAPK4 ELISA Kits) and MEKK1 (zeige MAP3K1 ELISA Kits) in a MAP kinase (zeige MAPK1 ELISA Kits) cascade to negatively regulate innate immune responses in plants.
The protein encoded by this gene is a member of the dual specificity protein kinase family, which acts as a mitogen-activated protein (MAP) kinase kinase. MAP kinases, also known as extracellular signal-regulated kinases (ERKs), act as an integration point for multiple biochemical signals. This protein kinase lies upstream of MAP kinases and stimulates the enzymatic activity of MAP kinases upon wide variety of extra- and intracellular signals. As an essential component of MAP kinase signal transduction pathway, this kinase is involved in many cellular processes such as proliferation, differentiation, transcription regulation and development.
ERK activator kinase 1
, MAP kinase kinase 1
, MAP kinase/Erk kinase 1
, MAPK/ERK kinase 1
, MAPKK 1
, dual specificity mitogen-activated protein kinase kinase 1
, mitogen-activated protein kinase kinase 1
, MEK 1
, protein kinase, mitogen-activated, kinase 1 (MAP kinase kinase 1)
, dual specificity mitogen activated protein kinase kinase 1
, mitogen activated protein kinase kinase 1
, protein kinase, mitogen activated, kinase 1, p45
, MAP kinase kinase or Erk Kinase, Dual specificity mitogen-activated protein kinase kinase, involved in ras mediated vulval induction, LEThal LET-537 (42.8 kD) (mek-2)