Use your antibodies-online credentials, if available.
Keine Produkte auf Ihrer Vergleichsliste.
Ihr Warenkorb ist leer.
Weitere Synonyme anzeigen
Wählen Sie die gewünschte Spezies
Human JNK Protein expressed in Wheat germ - ABIN1310303
Prause, Christensen, Billestrup, Mandrup-Poulsen: JNK1 protects against glucolipotoxicity-mediated beta-cell apoptosis. in PLoS ONE 2014
Human JNK Protein expressed in Baculovirus infected Insect Cells - ABIN593493
Sury, McShane, Hernandez-Miranda, Birchmeier, Selbach et al.: Quantitative proteomics reveals dynamic interaction of c-Jun N-terminal kinase (JNK) with RNA transport granule proteins splicing factor proline- and glutamine-rich (Sfpq) and non-POU ... in Molecular & cellular proteomics : MCP 2015
Here we uncover a cell non-autonomous requirement for the Epidermal growth factor receptor (Egfr (zeige EGFR Proteine)) pathway in the lateral epidermis for sustained dpp (zeige TGFb Proteine) expression in the LE. Specifically, we demonstrate that Egfr (zeige EGFR Proteine) pathway activity in the lateral epidermis prevents expression of the gene scarface (scaf), encoding a secreted antagonist of JNK signaling
n addition to significantly increasing the number of JNK target genes identified so far, our results reveal that the LE is a highly heterogeneous morphogenetic organizer, sculpted through crosstalk between JNK, segmental and AP signalling. This fine-tuning regulatory mechanism is essential to coordinate morphogenesis and dynamics of tissue sealing
malignant transformation of the ras(V12)scrib(1) tumors requires bZIP protein Fos, the ETS (zeige ETS1 Proteine)-domain factor Ets21c and the nuclear receptor Ftz-F1 (zeige NR5A2 Proteine), all acting downstream of Jun-N-terminal kinase.
Diminished MTORC1-dependent JNK activation underlies the neurodevelopmental defects associated with lysosomal dysfunction.
ROS (zeige ROS1 Proteine)/JNK/p38 (zeige MAPK14 Proteine)/Upd (zeige UROD Proteine) stress responsive module restores tissue homeostasis. This module is not only activated after cell death induction but also after physical damage and reveals one of the earliest responses for imaginal disc regeneration.
Significantly, the JNK pathway is responsible for the majority of the phenotypes and transcriptional changes downstream of Notch (zeige NOTCH1 Proteine)-Src (zeige SRC Proteine) synergy.
This study demonstrated that the mechanism by which Bsk (zeige FRK Proteine) is required for pruning is through reducing the membrane levels of the adhesion molecule (zeige NCAM1 Proteine) Fasciclin II (zeige NCAM2 Proteine) (FasII)
Study solves the crystal structure of unphosphorylated DJNK in complex with adenylyl imidodiphosphate (AMP (zeige AMPH Proteine)-PNP (zeige NP Proteine)) and magnesium.
PERK/ATF4 activated the JNK pathway through Rac1 and Slpr activation in apoptotic cells.
Data show that oxidative stress and neuroinflammation are intrinsic components of TDP-43 (zeige TARDBP Proteine)-associated neurodegeneration and the balance between cytoprotective JNK and cytotoxic p38 (zeige MAPK14 Proteine) signaling dictates phenotypic outcome to TDP-43 (zeige TARDBP Proteine) expression in Drosophila.
These results suggest that Bacteroides fragilis enterotoxin induced accumulation of autophagosomes in endothelial cells, but activation of a signaling pathway involving JNK, AP-1 (zeige FOSB Proteine), and CHOP (zeige DDIT3 Proteine) may interfere with complete autophagy.
The findings indicate that ERK (zeige EPHB2 Proteine) and JNK signaling pathways, as well as NF-kappaB (zeige NFKB1 Proteine)-mediated signaling are important contributors to the pathogenesis of Kashin-Beck disease.
The data suggested that JNK-enhanced Tudor-SN phosphorylation promotes the interaction between Tudor-SN and G3BP (zeige G3BP1 Proteine) and facilitates the efficient recruitment of Tudor-SN into stress granules under conditions of sodium arsenite-induced oxidative stress.
Taken together, our data demonstrate that JNK regulates triple-negative breast cancer (TNBC)tumorigenesis by promoting CSC phenotype through Notch1 (zeige NOTCH1 Proteine) signaling via activation of c-Jun (zeige JUN Proteine) and indicate that JNK/c-Jun/Notch1 (zeige NOTCH1 Proteine) signaling is a potential therapeutic target for TNBC
Here, the authors show that the CDK (zeige CDK4 Proteine) inhibitor p21 (CDKN1A (zeige CDKN1A Proteine)) maintains the viability of DNA damage-induced senescent cells. Upon p21 (zeige CDKN1A Proteine) knockdown, senescent cells acquired multiple DNA lesions that activated ataxia telangiectasia mutated (ATM (zeige ATM Proteine)) and nuclear factor (NF)-kappaB (zeige NFKB1 Proteine) kinase, leading to decreased cell survival. NF-kappaB (zeige NFKB1 Proteine) activation induced TNF-alpha (zeige TNF Proteine) secretion and JNK activation to mediate death of senescent cells in a...
Results indicate that cordycepin promotes caveolin-1 (CAV1 (zeige CAV1 Proteine))upregulation to enhance c-jun N-terminal kinase (JNK)/forkhead box O3A (zeige FOXO3 Proteine) protein (Foxo3a (zeige FOXO3 Proteine)) signaling pathway activation, inducing apoptosis in lung cancer cells.
The combination of 2-deoxyglucose (2-DG) and ABT-199 initiated cell death through the reduction of myeloid cell leukemia sequence 1 protein (Mcl-1 (zeige MCL1 Proteine)) expression and c-Jun N-terminal kinase 1 (JNK1) activation and subsequent Bcl-xL (zeige BCL2L1 Proteine) protein degradation.
identified the c-Jun N-terminal kinase 1 (JNK1) as the kinase involved in the phosphorylation of NEIL1 (zeige NEIL1 Proteine)
This study suggests that advanced glycation end products (AGEs) and activation of AGEs receptor could induce the proliferation of smooth muscle cells from Saphenous vein but not smooth muscle cells from internal thoracic arteryvia MAP kinase (zeige MAPK1 Proteine) pathway in diabetes mellitus.
The increase in c-Jun N-terminal kinase (c-Jun) and specificity protein 1 (SP1 (zeige SP1 Proteine)) expressions was positively correlated with transforming growth factor beta 1 (TGFbeta1 (zeige TGFB1 Proteine)) in both high glucose-treated renal mesangial cells (HRMCs) and diabetic kidneys.
JNK1-mediated NLRP3 (zeige NLRP3 Proteine) phosphorylation at S194 is a critical priming event and is essential for NLRP3 (zeige NLRP3 Proteine) inflammasome activation.
The purpose of this study was to investigate mechanisms that govern the regulation of Npnt (zeige NPNT Proteine) gene expression by IL-1beta (zeige IL1B Proteine) in osteoblasts.
Doxorubicin (Dox)-administration to cardiomyocytes increased the levels of reactive oxygen species (ROS (zeige ROS1 Proteine)) in a time-dependent manner that followed the activation of stress-induced proteins p53 (zeige TP53 Proteine), p38 (zeige CRK Proteine) and JNK MAPKs, culminating in an increase in autophagy and apoptosis markers.
IL-6 (zeige IL6 Proteine) likely up-regulates IRP1 (zeige ACO1 Proteine) and DMT1 (zeige SLC11A2 Proteine) expression and down-regulates FPN1 (zeige SLC40A1 Proteine) expression in BV2 microglial cells through JNK signaling pathways
Study examined whether JNK is present at the presynaptic site and its activity after presynaptic NMDA receptors stimulation; found that JNK, via the JBD domain, acts as a physiological effector on T-SNARE (zeige VTI1B Proteine) proteins; data suggest that JNK-dependent phosphorylation of T-SNARE (zeige VTI1B Proteine) proteins may have an important functional role in synaptic plasticity.
JNK signaling, which is inversely correlated with WNT4 (zeige WNT4 Proteine), plays an important role in perinatal germline cyst breakdown and primordial follicle formation by regulating E-cadherin (zeige CDH1 Proteine) junctions between oocytes in mouse ovaries.
It was concluded that compounds targeting JNK1 activity in brain and adipose tissue, which do not accumulate in the skin, may be safer and most effective.
JNK1 activation suppresses antifungal immunity in mice. JNK1-deficient mice had a significantly higher survival rate than wild-type control mice in response to Candida albicans infection, and the expression of JNK1 in hematopoietic innate immune cells was critical for this effect.
activation of JNK in the endoplasmic reticulum stress response precedes activation of XBP1 (zeige XBP1 Proteine).
Data suggest that single muscle immobilization induces a shift of myosin heavy chain (MHC) isoforms composition toward a faster contractile phenotype and decreases the polymorphic profile of single fibres, and that activation of p38 and JNK could be a potential mechanism involved in these contractile phenotype modifications during muscle immobilization.
Hyperosmotic Shock Engages Two Positive Feedback Loops through Caspase-3 (zeige CASP3 Proteine)-dependent Proteolysis of JNK1-2 and Bid (zeige BID Proteine).
JNK signaling is required to establish microtubule stability and maintain tissue cohesion in the gut (zeige GUSB Proteine).
Data show that the death pathway is independent of ERK (zeige MAPK1 Proteine) but relies on activating Bad phosphorylation through the control of both kinases Cdk1 (zeige CDK1 Proteine) and JNK.
study reports MPK8 connects protein phosphorylation, Ca(2 (zeige CA2 Proteine))+ and ROS (zeige ROS1 Proteine) in wound-signaling pathway; suggests 2 major activation modes, Ca(2 (zeige CA2 Proteine))+/CaMs and MAP kinase (zeige MAPK1 Proteine) phosphorylation cascade, converge at MPK8 to monitor or maintain an essential part of ROS (zeige ROS1 Proteine) homeostasis
our data provide strong evidence that Jip3 in fact serves as an adapter protein linking these cargos to dynein
P38 (zeige MAPK14 Proteine) and JNK have opposing effects on persistence of in vivo leukocyte migration in zebrafish.
A dorsalization pathway that is exerted by Axin (zeige AXIN1 Proteine)/JNK signaling and its inhibitor Aida (zeige AIDA Proteine) during vertebrate embryogenesis, is defined.
JNK-Mmp13 (zeige MMP13 Proteine) signaling pathway plays an essential role in regulating the innate immune cell migration in response to severe injury in vivo
Our genetic study unravelled the underlying pathway where JNK-1 is acting independently of insulin (zeige INS Proteine)-IGF-1 (zeige IGF1 Proteine) signalling (IIS) pathway to modulate longevity. In support of in vivo results in silico docking study of UA with C. elegans JNK-1 ATP-binding site suggested promising binding affinity exhibiting binding energy of -8.11 kcalmol(-1). UA induced JNK-1 activation in wild-type animals underlie the importance of pharmacologi
JNK-1 directly interacts with and phosphorylates DAF-16. Moreover, in response to heat stress, JNK-1 promotes the translocation of DAF-16 into the nucleus.
The present study shows in Caenorhabditis elegans that ambient temperature (1-37 degrees C) specifically influences the activation (phosphorylation) of the MAP kinase JNK-1 as well as the nuclear translocation of DAF-16.
the stress response is controlled by a c-Jun N-terminal kinase (JNK)-like mitogen-activated protein kinase (zeige MAPK1 Proteine) (MAPK (zeige MAPK1 Proteine)) signaling pathway, which is regulated by MLK-1 (zeige MAP3K9 Proteine) MAPK (zeige MAPK1 Proteine) kinase kinase (MAPKKK), MEK-1 (zeige MAP2K1 Proteine) MAPK (zeige MAPK1 Proteine) kinase (MAPKK), and KGB-1 (zeige KCNJ3 Proteine) JNK-like MAPK (zeige MAPK1 Proteine).
The protein encoded by this gene is a member of the MAP kinase family. MAP kinases act as an integration point for multiple biochemical signals, and are involved in a wide variety of cellular processes such as proliferation, differentiation, transcription regulation and development. This kinase is activated by various cell stimuli, and targets specific transcription factors, and thus mediates immediate-early gene expression in response to cell stimuli. The activation of this kinase by tumor-necrosis factor alpha (TNF-alpha) is found to be required for TNF-alpha induced apoptosis. This kinase is also involved in UV radiation induced apoptosis, which is thought to be related to cytochrom c-mediated cell death pathway. Studies of the mouse counterpart of this gene suggested that this kinase play a key role in T cell proliferation, apoptosis and differentiation. Four alternatively spliced transcript variants encoding distinct isoforms have been reported.
, JUN kinase
, Jun N-terminal kinase
, Jun NH2-terminal kinase
, Jun-N-terminal kinase
, c-Jun N-terminal kinase
, c-Jun aminoterminal kinase
, c-Jun-N-terminal kinase
, drosophila JNK
, JUN N-terminal kinase
, MAP kinase 8
, c-Jun N-terminal kinase 1
, mitogen-activated protein kinase 8 isoform JNK1 alpha1
, mitogen-activated protein kinase 8 isoform JNK1 beta2
, stress-activated protein kinase 1
, stress-activated protein kinase 1c
, JNK1 beta1 protein kinase
, MAPK 8
, mitogen activated protein kinase 8
, protein kinase mitogen-activated 8
, stress-activated protein kinase JNK1
, SAPK gamma
, c-jun NH2-terminal kinase
, p54 gamma
, mitogen-activated protein kinase 8