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Human BCL2 Protein expressed in Wheat germ - ABIN1346542
Su, Guo, Qi: Threonine 56 phosphorylation of Bcl-2 is required for LRRK2 G2019S-induced mitochondrial depolarization and autophagy. in Biochimica et biophysica acta 2014
The BAK1 (zeige BAK1 Proteine)/BCL2 ratio was positively correlated with the results of audiometric tests. Our results indicate that BAK (zeige BAK1 Proteine)-mediated apoptosis may be a core mechanism in the progression of age-related hearing impairment in humans
A decrease in miR (zeige MLXIP Proteine)-184 level by E6 oncoprotein may predict unfavorable response to cisplatin-based chemotherapy in HPV-infected non-small cell lung carcinoma patients via increasing Bcl-2 expression.
these findings confirm that over-expression of BCL2 and MYC (zeige MYC Proteine) proteins by IHC in DLBCL is associated with a poor prognosis in R-CHOP (zeige DDIT3 Proteine)-treated patients.
dose-intensified immunochemotherapy with or without HDC (zeige HDC Proteine)/ASCT was not effective in patients with de novo DLBCL, who had advanced disease and concurrent overexpression of MYC (zeige MYC Proteine) and BCL2 protein.
These results suggested together that tBHQ could ameliorate arsenic-induced cytotoxicity and apoptosis, which might be linked with the induction of Nrf2 (zeige GABPA Proteine)-dependent antioxidant responses as well as stabilization of anti-apoptotic factor Bcl-2 in human keratinocytes.
There were higher expressions of XIAP (zeige XIAP Proteine) (p = 0.0032) and Bcl-2 (p = 0.0351) in the glioblastoma samples compared to the control samples of normal brain. These results raise the question of whether Bcl-2 and XIAP (zeige XIAP Proteine) genes can be responsible for the inhibition of programmed cell death in glioblastomas.
These findings uncover a novel mechanism through which mitochondrial PKM2 phosphorylates Bcl2 and inhibits apoptosis directly.
Study reveals a previously unrecognized synergism between ETV6 (zeige ETV6 Proteine)/RUNX1 (zeige RUNX1 Proteine) and BCL2 impacting on malignant disease and autoimmunity.
beta-asarone changed the cellular morphology, inhibited cell proliferation, and enhanced the expression of P53 (zeige TP53 Proteine), LC3 (zeige MAP1LC3A Proteine)-II/I, Beclin-1 (zeige BECN1 Proteine), AMPK (zeige PRKAA1 Proteine), and pAMPK while inhibiting the expression of P62 (zeige GTF2H1 Proteine), Bcl-2, mTOR (zeige FRAP1 Proteine), and pmTOR in glioma cells.
anti-apoptotic molecules BclxL (zeige BCL2L1 Proteine) and Bcl-2 and the pro-apoptotic factors BAD and BID (zeige BID Proteine) cooperate to promote migration of triple-negative breast cancer cells stimulated with cl-CD95L (zeige FASL Proteine).
Bcl2 is the autophagy-related target of miR (zeige MLXIP Proteine)-449a.
Acute ethanol exposure induced autophagy-mediated heart toxicity and injury mainly through the ROS (zeige ROS1 Proteine)-JNK (zeige MAPK8 Proteine)-Bcl-2 signaling pathway.
Th17 cells are resistant to glucocorticoid-induced apoptosis and cytokine suppression, at least in part due to high levels of BCL-2. These findings support a role of Th17 cells in glucocorticoid-resistant inflammatory conditions such as certain endotypes of asthma.
E2 protects skeletal myoblasts against apoptosis induced by H2 O2 modulating p53 (zeige TP53 Proteine) and FoxO (zeige FOXO3 Proteine) transcription factors and then their target genes Bcl-2, Bim (zeige BCL2L11 Proteine), Puma (zeige BBC3 Proteine), PERP (zeige PERP Proteine), and MDM2 (zeige MDM2 Proteine), without affecting Noxa (zeige PMAIP1 Proteine) gene.
Bcl-2 expression has a significant impact on the mineralogical content of enamel crystals of tooth structure
The results suggest that CARP (zeige ANKRD1 Proteine) can protect against hypoxia-reperfusion induced cardiomyocyte apoptosis, possibly through increasing anti-apoptosis Bcl2 gene expression.
This study provides evidence from transgenic mouse models that Crebbp (zeige CREBBP Proteine) deletion results in deficits in B-cell development and can cooperate with Bcl2 overexpression to promote B-cell lymphoma.
an essential role for the binding of BCL2 to BIM (zeige BCL2L11 Proteine) in the survival of noncycling NK cells.
LIGHT signalling pathway combined with IFN-gamma (zeige IFNG Proteine) induces beta cells apoptosis via an NF-kappaB (zeige NFKB1 Proteine)/Bcl2-dependent mitochondrial pathway.
These results suggest a role for mitochondrial p53 (zeige TP53 Proteine) activity in promoting hair cell death due to aminoglycosides, likely upstream of Bax (zeige BAX Proteine) and Bcl2.
Zebrafish gene expressions of P53 (zeige TP53 Proteine), Bcl-2, Bax (zeige BAX Proteine) and caspase-3 (zeige CASP3 Proteine) were elevated after exposure with microcystin-LR under different ambient temperatures.
Analysis using clinical biopsy specimens revealed autophagy and increased levels of BCL2, S1P1 (zeige S1PR1 Proteine), and ICAM1 (zeige ICAM1 Proteine) in human T-lymphoblastic lymphoma compared with T-lymphoblastic leukemia.
Real-time RT-PCR revealed acetaminophen treatment of zebrafish embryos decreased the expression of cox2 and bcl2, but increased p53 (zeige TP53 Proteine) expression.
Leukemia onset was dramatically accelerated in transgenic fish overexpressing human Notch1 (zeige NOTCH1 Proteine) and fish bcl-2, indicating synergy between the Notch (zeige NOTCH1 Proteine) pathway and the bcl2-mediated antiapoptotic pathway.
Over-expression of STC-1 (zeige STC1 Proteine) up-regulated Bcl-2 protein expression and slightly down-regulated caspase-3 (zeige CASP3 Proteine) production in the damaged cells. Findings from this study suggest that STC-1 (zeige STC1 Proteine) plays a protective role in intestinal cells through an antioxidant mechanism.
BoHV-5 replication apparently modulates BCL-2 expression and gene transcription, enhancing production of virus progeny, but does not increase Bax (zeige BAX Proteine) expression.
G3139, a BCL-2 antisesnse oligonucleotide is a promising candidate for treatment of patients with imatinib-resistant Ph-positive leukemia.
role of vascular endothelial growth factor receptor-1 (zeige FLT1 Proteine) in Bcl-2 expression
apoptosis-inducing factor (zeige AIFM1 Proteine) was expressed in luminal alveolar cells and, in concert with a change in bax (zeige BAX Proteine) protein to bcl-2 protein ratio, might contribute to signalling of a change in the dynamic balance of the cell population as lactation progresses
mRNA expression of Bax (zeige BAX Proteine), Bcl-2, caspase-3 (zeige CASP3 Proteine) and-7 cannot be used as a reliable apoptosis detection method.
These results propose an additional mechanism whereby resveratrol may exert its cardioprotective effects and suggest a key role for Bcl-2 in the resveratrol anti-apoptotic action, especially in disrupting peroxynitrite-triggered mitochondrial pathway.
bcl-2 and bax (zeige BAX Proteine) were expressed strongly in denervated guinea-pig facial muscle. [bcl-2; bax (zeige BAX Proteine)]
excessive apoptosis does occur in acetabular cartilage with developmental dislocations of the hip, and is positively correlated with high caspase-3 (zeige CASP3 Proteine) expression as well as low Bcl-2 expression.
These results indicate that RI-PostC can ameliorate myocardial ischemia-reperfusion injury and increase the Bcl-2/Bax ratio through a mechanism involving protein kinase C.
Cinobufagin can remarkably inhibit the proliferation and induce the apoptosis of lens epithelial cells by increasing expression of bax (zeige BAX Proteine) and decreasing expression of bcl2.
Elevated local temperature of the testis buried in the inguinal pocket increases the apoptosis of spermatogenic cells, and the spermatogenic cell apoptosis is highly correlated with the decreased expression of Bcl-2 and increased expression of Bax (zeige BAX Proteine).
Our data indicate that exposure to rabbits to Pb(Ac)(2) caused a significant increase of apoptosis protein p53 (zeige TP53 Proteine) and decrease in the antiapoptotic BCl2 proteins.
Isoflurane delayed preconditioning can inhibit the apoptosis of myocardium by up-regulating the expression of Bcl-2 and down-regulating the activation of caspase-3 (zeige CASP3 Proteine).
Data show that the damaged electron transport chain leads to bcl-2 depletion and MPT opening.
This gene encodes an integral outer mitochondrial membrane protein that blocks the apoptotic death of some cells such as lymphocytes. Constitutive expression of BCL2, such as in the case of translocation of BCL2 to Ig heavy chain locus, is thought to be the cause of follicular lymphoma. Two transcript variants, produced by alternate splicing, differ in their C-terminal ends.
apoptosis regulator Bcl-2
, protein phosphatase 1, regulatory subunit 50
, B cell lymphoma 2 associated oncogene
, B-cell leukemia/lymphoma 2
, Bcl2-like protein
, BCL2B-cell CLL/lymphoma 2
, B-cell lymphoma protein 2
, B-cell CLL/lymphoma 2
, LOW QUALITY PROTEIN: apoptosis regulator Bcl-2
, Apoptosis regulator Bcl-2