Ran GTPase Activating Protein 1 Proteine (RANGAP1)

Auf www.antikoerper-online.de finden Sie aktuell 6 Ran GTPase Activating Protein 1 (RANGAP1) Proteine von 4 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Ran GTPase Activating Protein 1 Antikörper (96) und Ran GTPase Activating Protein 1 Kits (2) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 112 Ran GTPase Activating Protein 1 Produkte verfügbar.
Synonyme:
ATRANGAP1, C79654, Fug1, mKIAA1835, RANGAP, rangap1, rangap1a, rangap1b, RAN GTPASE-ACTIVATING PROTEIN 1, RAN GTPase activating protein 1, rna1p, SD
alle Proteine anzeigen Gen GeneID UniProt
RANGAP1 5905 P46060
RANGAP1 19387 P46061
Ratte RANGAP1 RANGAP1 362965  

Ran GTPase Activating Protein 1 Proteine (RANGAP1) nach Spezies

Weitere Proteine zu Ran GTPase Activating Protein 1 Interaktionspartnern

Human Ran GTPase Activating Protein 1 (RANGAP1) Interaktionspartner

  1. RanGAP1 upregulation is associated with drug resistance in Chronic Myeloid Leukemia (zeige BCL11A Proteine).

  2. Abnormal localization of RanGAP1 was found in cortex of Huntington's disease patients.

  3. our results elucidate that RanGAP1 is actively transported between the nuclear and cytoplasmic compartments, and that the cytoplasmic and NPC (zeige NPC1 Proteine) localization of RanGAP1 is dependent on CRM1 (zeige XPO1 Proteine)-mediated nuclear export.

  4. immune cell adaptor SLP-76 (zeige LCP2 Proteine) binds directly to SUMO-RanGAP1 of cytoplasmic fibrils of the nuclear pore complex, and this interaction is needed for optimal NFATc1 (zeige NFATC1 Proteine) and NF-kappaB (zeige NFKB1 Proteine) p65 (zeige GORASP1 Proteine) nuclear entry in T cells

  5. Differentiation of human coronary artery smooth muscle cell to a contractile phenotype by stepwise serum depletion leads to significant reduction of RanGAP1 protein levels.

  6. Determinants of small ubiquitin-like modifier 1 (SUMO1 (zeige SUMO1 Proteine)) protein specificity, E3 ligase, and SUMO-RanGAP1 binding activities of nucleoporin (zeige AGFG2 Proteine) RanBP2.

  7. Analysis of the dynamics of E2(Ubc9)-SUMO-Target(RanGAP1) in the absence and presence of E3(RanBP2) revealed that two different allosteric sites regulate the ligase activity.

  8. the RanGAP1 consensus sumoylation site and SUMO-1 (zeige SUMO1 Proteine) C terminus are both conformationally flexible

  9. the 3.0-A crystal structure of a four-protein complex of Ubc9, a Nup358/RanBP2 E3 ligase domain (IR1-M) and SUMO-1 conjugated to the carboxy-terminal domain of RanGAP1

  10. RanGAP1 is phosphorylated on Ser (zeige SIGLEC1 Proteine)-358 in vivo & in vitro. Phosphorylated RanGAP1, but not a mutant at 358S, formed a stable ternary complex with Ran and RanBP1 (zeige RANBP1 Proteine) in vivo, suggesting that its 358S phosphorylation affects the Ran system.

Mouse (Murine) Ran GTPase Activating Protein 1 (RANGAP1) Interaktionspartner

  1. data suggest that remodeling of the RanGAP-mediated nuclear transport system plays a key role in cell cycle exit for terminal differentiation of cortical neurons

  2. nuclear localization of Ran was strongly increased in MYCBP2-deficient DRGs

  3. immune cell adaptor SLP-76 (zeige LCP2 Proteine) binds directly to SUMO-RanGAP1 of cytoplasmic fibrils of the nuclear pore complex, and this interaction is needed for optimal NFATc1 (zeige NFATC1 Proteine) and NF-kappaB (zeige NFKB1 Proteine) p65 (zeige NFkBP65 Proteine) nuclear entry in T cells

  4. These data suggest a dual function of the Nup358-RanGAP1 complex as a coordinator of importin beta (zeige KPNB1 Proteine) recycling and reformation of novel import complexes.

  5. Protection from isopeptidase-mediated deconjugation regulates paralog-selective sumoylation of RanGAP1.

Arabidopsis thaliana Ran GTPase Activating Protein 1 (RANGAP1) Interaktionspartner

  1. The data show that plant development is differentially affected by RanGAP mutant allele combinations of increasing severity and requires the GAP activity of RanGAP, while the subcellular positioning of RanGAP is dispensable.

  2. AtRanGAP1 has a mitotic trafficking pattern uniquely different from that of vertebrate RanGAP.

  3. In a wip1-1/wip2-1/wip3-1 triple mutant, RanGAP1 is dislocated from the nuclear envelope in undifferentiated root-tip cells, whereas nuclear envelope targeting in differentiated root cells and targeting to the cell plate remain intact.

  4. Data suggest that an unanticipated complexity of RanGAP nuclear envelope targeting and at least one member of each NE-associated coiled-coil and transmembrane domains protein family is required for RanGAP targeting in root tip cells.

  5. propose that Arabidopsis RanGAP, a continuous positive protein marker of the plant division plane, has a role in spatial signaling during plant cell division

  6. These data suggest that both HSC70-1 and the WPP-domain proteins play a role in facilitating WIT1 nuclear envelope targeting; this may be the first described in planta activity for the WPP-domain proteins.

Ran GTPase Activating Protein 1 (RANGAP1) Protein Überblick

Protein Überblick

RanGAP1, is a homodimeric 65-kD polypeptide that specifically induces the GTPase activity of RAN, but not of RAS by over 1,000-fold. RanGAP1 is the immediate antagonist of RCC1, a regulator molecule that keeps RAN in the active, GTP-bound state. The RANGAP1 gene encodes a 587-amino acid polypeptide. The sequence is unrelated to that of GTPase activators for other RAS-related proteins, but is 88% identical to Fug1, the murine homolog of yeast Rna1p. RanGAP1 and RCC1 control RAN-dependent transport between the nucleus and cytoplasm. RanGAP1 is a key regulator of the RAN GTP/GDP cycle.

Alternative names and synonyms associated with Ran GTPase Activating Protein 1 (RANGAP1)

  • Ran GTPase activating protein 1 (RANGAP1)
  • ran GTPase activating protein 1 (TERG_02084)
  • Ran GTPase activating protein 1 (rangap1-b)
  • RAN GTPase activating protein 1 (Rangap1)
  • chondroadherin-like (CHADL)
  • Ran GTPase activating protein 1 (rangap1-a)
  • RAN GTPase-activating protein 1 (RANGAP1)
  • ATRANGAP1 Protein
  • C79654 Protein
  • Fug1 Protein
  • mKIAA1835 Protein
  • RANGAP Protein
  • rangap1 Protein
  • rangap1a Protein
  • rangap1b Protein
  • RAN GTPASE-ACTIVATING PROTEIN 1 Protein
  • RAN GTPase activating protein 1 Protein
  • rna1p Protein
  • SD Protein

Bezeichner auf Proteinebene für RANGAP1

ran GTPase-activating protein 1 , ran GTPase activating protein 1 , Ran GTPase activating protein 1 , Ran GTPase activating protein 1 b , segregation distorter homolog , segregation distortion , RAN GTPase activating protein 1 , RAN GTPase activating protein 1 a

GENE ID SPEZIES
100628308 Equus caballus
100153811 Sus scrofa
10378741 Trichophyton rubrum CBS 118892
100543860 Meleagris gallopavo
616055 Bos taurus
100337588 Xenopus laevis
5905 Homo sapiens
19387 Mus musculus
481234 Canis lupus familiaris
362965 Rattus norvegicus
417997 Gallus gallus
379922 Xenopus laevis
825488 Arabidopsis thaliana
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