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Data suggest that protein phosphatase 1 (zeige PPP1CB ELISA Kits), catalytic subunit, alpha isoform (PPP1CA) is a candidate sero-diagnostic and prognostic marker for badder cancer (BC).
Rif1 (zeige INSL6 ELISA Kits) can mediate MCM dephosphorylation at replication forks and that the stability of dephosphorylated replisomes strongly depends on Chk1 (zeige CHEK1 ELISA Kits) activity.
Data, including data from studies using cells from knockout mice, suggest that gasotransmitter H(2)S up-regulates eIF2a (zeige EIF2S1 ELISA Kits) phosphorylation by inhibiting PPP1CA via persulfidation, which in turn leads to transient suppression of global translation and activation of Atf4 (zeige ATF4 ELISA Kits) expression. (eIF2a (zeige EIF2S1 ELISA Kits) = eukaryotic initiation factor-2alpha (zeige EIF2S1 ELISA Kits); PPP1CA = protein phosphatase 1 catalytic subunit alpha; Atf4 (zeige ATF4 ELISA Kits) = activating transcription factor 4 (zeige ATF4 ELISA Kits))
Protein phosphatase 1 (zeige PPP1CB ELISA Kits) (PP1 (zeige PPA1 ELISA Kits)) forms stable complexes with PP1 (zeige PPA1 ELISA Kits)-interacting proteins (PIPs (zeige GPRASP1 ELISA Kits)) that guide the phosphatase throughout its life cycle and control its fate and function.
The authors found that RNA recognition motif 1 (RRM1) in SRSF1 binds PP1 and represses its catalytic function through an allosteric mechanism.
this study shows a pivotal role for PP1 (zeige PPA1 ELISA Kits) in impeding IRF7 (zeige IRF7 ELISA Kits)-mediated IFN-alpha (zeige IFNA ELISA Kits) production in host immune responses
The data support a model where Cdc7 (zeige CDC7 ELISA Kits) (de)phosphorylation is the molecular switch for the activation and inactivation of DNA replication in mitosis, directly connecting Cdc7 (zeige CDC7 ELISA Kits) and PP1a/Cdk1 (zeige CDK1 ELISA Kits) to the regulation of once-per-cell cycle DNA replication in mammalian cells.
These results indicate that PP1 (zeige PPA1 ELISA Kits) is recruited to the extracellular calcium-dependent E-cadherin (zeige CDH1 ELISA Kits)-catenin-PIP5K1a complex in the plasma membrane to activate PIP5K1a, which is required for PLC (zeige HSPG2 ELISA Kits)-g1 activation leading to keratinocyte differentiation.
Data suggest that targeting protein phosphatase 1 catalytic subunit (zeige PPP1CB ELISA Kits) (PP1alpha) or the androgen receptor AR (zeige AR ELISA Kits)-PP1alpha interaction may be effective in castration-resistant prostate cancer (CRPC).
Both PP-1 and PP-2A are directly involved in regulating eye development, and are aberrantly expressed in cataract and glaucoma patients. (Review)
Data, including data from studies using transgenic/knockout mice, suggest that Ppp1ca and Gnb1 (zeige GNB1 ELISA Kits) interact in quiescent platelets; then, Ppp1ca and Plcb3 (zeige PLCB3 ELISA Kits) interact during platelet aggregation; thus, Gnb1 (zeige GNB1 ELISA Kits) enlists Ppp1ca to modulate G protein-coupled receptor (zeige GPR34 ELISA Kits) signaling. (Ppp1ca = protein phosphatase 1 (zeige PPP1CB ELISA Kits), catalytic subunit alpha; Gnb1 (zeige GNB1 ELISA Kits) = guanine nucleotide-binding protein (zeige TRIM23 ELISA Kits), subunit beta-1; Plcb3 (zeige PLCB3 ELISA Kits) = phospholipase C (zeige PLC ELISA Kits), subunit beta-3)
Ang IV functions via regulating the activity of PP1
Cell surface expression of the major amyloid-beta peptide (Abeta (zeige APP ELISA Kits))-degrading enzyme, neprilysin (zeige MME ELISA Kits), depends on phosphorylation by mitogen-activated protein kinase (zeige MAPK1 ELISA Kits)/extracellular signal-regulated kinase kinase (MEK (zeige MDK ELISA Kits)) and dephosphorylation by protein phosphatase 1a (zeige PPM1A ELISA Kits).
analysis of selective regulation of NR2B (zeige GRIN2B ELISA Kits) by protein phosphatase-1 (zeige PPP1CB ELISA Kits) for the control of the NMDA receptor in neuroprotection
alteration of lipid rafts is an early event in the apoptotic cascade indirectly induced by interleukin-4 (zeige IL4 ELISA Kits) deprivation via PP1alpha activation, dephosphorylation of cytoplasmic Bad, and caspase (zeige CASP3 ELISA Kits) activation
Data show that Nck (zeige NCK1 ELISA Kits) (isoforms 1 and 2) as a component of the CReP (zeige PPP1R15B ELISA Kits)/PP1c holophosphatase complex contributes to maintain eIF2alpha (zeige EIF2A ELISA Kits) in a hypophosphorylated state, and modulates translation and eIF2alpha (zeige EIF2A ELISA Kits) signaling in response to ER stress.
Our system may be useful for the elucidation of the mechanism of morphological maturation of neuronal cells such as dorsal root ganglion neurons that express SREC-I (zeige SCARF1 ELISA Kits) during early development.
Ppp1ca was identified in the study.
overexpression of two out of five PPP1CA alternative spliced variants reduced tumor cell growth and the downregulation of the protein to hemizygosity increased the anchorage-independent growth
Results demonstrate myofilament regulation by protein phosphatase type 1 alpha and CapZ (zeige CAPZA1 ELISA Kits), and support the concept that cardiac Z-discs are vital components in intracellular signalling.
The protein encoded by this gene is one of the three catalytic subunits of protein phosphatase 1 (PP1). PP1 is a serine/threonine specific protein phosphatase known to be involved in the regulation of a variety of cellular processes, such as cell division, glycogen metabolism, muscle contractility, protein synthesis, and HIV-1 viral transcription. Increased PP1 activity has been observed in the end stage of heart failure. Studies in both human and mice suggest that PP1 is an important regulator of cardiac function. Mouse studies also suggest that PP1 functions as a suppressor of learning and memory. Three alternatively spliced transcript variants encoding different isoforms have been found for this gene.
protein phosphatase 1, catalytic subunit, alpha isoform
, serine/threonine protein phosphatase PP1-alpha 1 catalytic subunit
, serine/threonine-protein phosphatase PP1-alpha catalytic subunit
, Protein phosphatase type 1 alpha, catalytic subunit
, protein phosphatase-1d
, protein phosphatase 1, catalytic subunit, alpha
, protein phosphatase 1A
, protein phosphatase 1A (formerly 2C), magnesium-dependent, alpha isoform
, protein phosphatase 2C isoform alpha
, PP1 alpha
, protein phosphatase 1 alpha