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Given the critical roles of TBK1 (zeige TBK1 Proteine), important regulatory mechanisms are required to regulate its activity. Among these, Optineurin (Optn) was shown to negatively regulate the interferon (zeige IFNA Proteine) response, in addition to its important role in membrane trafficking, protein secretion, autophagy and cell division.
E50K, M98K, Q398X and E478G mutations in OPTN affect neuronal viability under normal or oxidative stress conditions.
These results suggest that the IRAK1 (zeige IRAK1 Proteine)-binding protein OPTN negatively regulates IL-1beta (zeige IL1B Proteine)/LPS (zeige IRF6 Proteine)-induced NF-kappaB (zeige NFKB1 Proteine) activation by preventing polyubiquitination of TRAF6 (zeige TRAF6 Proteine).
This study therefore provides novel information regarding the role of Optn during T-cell activation, suggesting the possible importance of Optn during inflammation and/or autoimmune diseases.
Frontotemporal dementia -linked mutations in gene OPTN encoding autophagy adaptor proteins , indicate that impaired autophagy might cause Frontotemporal dementia.
The present study provides insight into the genetic or haplotype variants of MYOC (zeige MYOC Proteine) and OPTN genes contributing to primary glaucoma. Haplotype variants identified in the present study may be regarded as potential contributing factors of primary glaucoma in Korea.
the E50K OPTN mutation markedly reduced the levels of miR (zeige MLXIP Proteine)-9, which led to alterations in REST and reduced expression levels of BDNF (zeige BDNF Proteine) in RGC-5 cells.
ALS (zeige IGFALS Proteine)-linked mutations in OPTN and TBK1 (zeige TBK1 Proteine) can interfere with mitophagy, suggesting that inefficient turnover of damaged mitochondria may represent a key pathophysiological mechanism contributing to neurodegenerative disease.
We conclude that OPTN mutations are associated with Amyotrophic lateral sclerosis
In combination with phosphorylation of S177 and S513, this posttranslational modification promotes recruitment and retention of OPTN/TBK1 (zeige TBK1 Proteine) on ubiquitinated, damaged mitochondria
These results suggest that the IRAK1 (zeige IRAK1 Proteine)-binding protein OPTN negatively regulates IL-1beta (zeige IL1B Proteine)/LPS (zeige TLR4 Proteine)-induced NF-kappaB (zeige NFKB1 Proteine) activation by preventing polyubiquitination of TRAF6 (zeige TRAF6 Proteine).
Report establishes optineurin as a positive regulator TBK1 (zeige TBK1 Proteine) via a bipartite interaction between these molecules.
OPTN-deficient mice were more susceptible to infection with Salmonella, confirming in vivo the importance of OPTN in bacterial clearance.
Optineurin knockdown enhances osteoclast differentiation. Optineurin inhibits osteoclast formation by modulating NF-kappaB (zeige NFKB1 Proteine) and IFN-beta (zeige IFNB1 Proteine) signaling.
Mutation in Optineurin gene is associated with Glaucoma.
Disruption in optineurin and myosin VI (zeige MYO6 Proteine)-mediated cellular trafficking is associated with amyotrophic lateral sclerosis.
OPTN plays a role in acute inflammation and neutrophil recruitment, potentially via defective macrophage proinflammatory cytokine secretion.
that ubiquitin (Ub)-binding domain mutants compromise the maturation of autophagosomes, which in turn interfered with optineurin-mediated autophagy and clearance of inclusion bodies
results indicated that optineurin trimers may be the basic unit of these oligomers. The oligomeric state can be affected by many factors that induce covalent bonds, such as H2O2 or E50K
Loss of optineurin in vivo results in elevated cell death and alters axonal trafficking dynamics
The optineurin gene and protein are evolutionary conserved between humans and the rhesus monkey. High similarity of ocular expression and tissue distribution between the two optineurin proteins.
This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.
, E3-14.7K-interacting protein
, Huntingtin interacting protein L
, huntingtin yeast partner L
, huntingtin-interacting protein 7
, huntingtin-interacting protein L
, nemo-related protein
, optic neuropathy-inducing protein
, transcription factor IIIA-interacting protein
, transcrption factor IIIA-interacting protein
, tumor necrosis factor alpha-inducible cellular protein containing leucine zipper domains
, 14.7K-interacting protein 2
, FIP-2-like protein