Optineurin Proteine (OPTN)

Bezeichnung:
Optineurin Proteine (OPTN)
Auf www.antikoerper-online.de finden Sie aktuell 8 Optineurin (OPTN) Proteine von 6 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Optineurin Antikörper (95) und Optineurin Kits (11) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 128 Optineurin Produkte verfügbar.
Synonyme:
4930441O07Rik, ALS12, Fip2, fj52f04, GLC1E, HIP7, HYPL, NRP, si:ch211-240l19.3, TFIIIA-INTP, wu:fj52f04, zgc:66386, zgc:77868
alle Proteine anzeigen Gen GeneID UniProt
OPTN 10133 Q96CV9
OPTN 246294 Q8R5M4
OPTN 71648 Q8K3K8

Weitere Synonyme anzeigen

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Human Optineurin (OPTN) Interaktionspartner

  1. This study therefore provides novel information regarding the role of Optn during T-cell activation, suggesting the possible importance of Optn during inflammation and/or autoimmune diseases.

  2. Frontotemporal dementia -linked mutations in gene OPTN encoding autophagy adaptor proteins , indicate that impaired autophagy might cause Frontotemporal dementia.

  3. The present study provides insight into the genetic or haplotype variants of MYOC (zeige MYOC Proteine) and OPTN genes contributing to primary glaucoma. Haplotype variants identified in the present study may be regarded as potential contributing factors of primary glaucoma in Korea.

  4. the E50K OPTN mutation markedly reduced the levels of miR (zeige MLXIP Proteine)-9, which led to alterations in REST and reduced expression levels of BDNF (zeige BDNF Proteine) in RGC-5 cells.

  5. ALS (zeige IGFALS Proteine)-linked mutations in OPTN and TBK1 (zeige TBK1 Proteine) can interfere with mitophagy, suggesting that inefficient turnover of damaged mitochondria may represent a key pathophysiological mechanism contributing to neurodegenerative disease.

  6. We conclude that OPTN mutations are associated with Amyotrophic lateral sclerosis

  7. In combination with phosphorylation of S177 and S513, this posttranslational modification promotes recruitment and retention of OPTN/TBK1 (zeige TBK1 Proteine) on ubiquitinated, damaged mitochondria

  8. Familial linkage studies for primary angle-closure glaucoma have been performed and identified OPTN causative primary angle-closure glaucoma disease

  9. Nine OPTN variants were identified in Chinese sporadic ALS patients, including 5 known SNPs and four novel missense mutations: c.407C > T (p.A136V), c.1184A > G (p.K395R), c.1352T > C (p.I451T), and c.1546G > C (p.E516Q) (all heterozygous).

  10. OPTN 691_692insAG is a founder mutation in Moroccan and Ashkenazi Jews with ALS.

Mouse (Murine) Optineurin (OPTN) Interaktionspartner

  1. This study therefore provides novel information regarding the role of Optn during T-cell activation, suggesting the possible importance of Optn during inflammation and/or autoimmune diseases.

  2. Report establishes optineurin as a positive regulator TBK1 (zeige TBK1 Proteine) via a bipartite interaction between these molecules.

  3. OPTN-deficient mice were more susceptible to infection with Salmonella, confirming in vivo the importance of OPTN in bacterial clearance.

  4. Optineurin knockdown enhances osteoclast differentiation. Optineurin inhibits osteoclast formation by modulating NF-kappaB (zeige NFKB1 Proteine) and IFN-beta (zeige IFNB1 Proteine) signaling.

  5. Mutation in Optineurin gene is associated with Glaucoma.

  6. Disruption in optineurin and myosin VI (zeige MYO6 Proteine)-mediated cellular trafficking is associated with amyotrophic lateral sclerosis.

  7. OPTN plays a role in acute inflammation and neutrophil recruitment, potentially via defective macrophage proinflammatory cytokine secretion.

  8. that ubiquitin (Ub)-binding domain mutants compromise the maturation of autophagosomes, which in turn interfered with optineurin-mediated autophagy and clearance of inclusion bodies

  9. results indicated that optineurin trimers may be the basic unit of these oligomers. The oligomeric state can be affected by many factors that induce covalent bonds, such as H2O2 or E50K

  10. Loss of optineurin in vivo results in elevated cell death and alters axonal trafficking dynamics

Zebrafish Optineurin (OPTN) Interaktionspartner

  1. Loss of optineurin in vivo results in elevated cell death and alters axonal trafficking dynamics

Rhesus Monkey Optineurin (OPTN) Interaktionspartner

  1. The optineurin gene and protein are evolutionary conserved between humans and the rhesus monkey. High similarity of ocular expression and tissue distribution between the two optineurin proteins.

Optineurin (OPTN) Protein Überblick

Protein Überblick

This gene encodes the coiled-coil containing protein optineurin. Optineurin may play a role in normal-tension glaucoma and adult-onset primary open angle glaucoma. Optineurin interacts with adenovirus E3-14.7K protein and may utilize tumor necrosis factor-alpha or Fas-ligand pathways to mediate apoptosis, inflammation or vasoconstriction. Optineurin may also function in cellular morphogenesis and membrane trafficking, vesicle trafficking, and transcription activation through its interactions with the RAB8, huntingtin, and transcription factor IIIA proteins. Alternative splicing results in multiple transcript variants encoding the same protein.

Alternative names and synonyms associated with Optineurin (OPTN)

  • optineurin (OPTN)
  • optineurin (optn)
  • optineurin (LOC100219034)
  • optineurin (Optn)
  • 4930441O07Rik Protein
  • ALS12 Protein
  • Fip2 Protein
  • fj52f04 Protein
  • GLC1E Protein
  • HIP7 Protein
  • HYPL Protein
  • NRP Protein
  • si:ch211-240l19.3 Protein
  • TFIIIA-INTP Protein
  • wu:fj52f04 Protein
  • zgc:66386 Protein
  • zgc:77868 Protein

Bezeichner auf Proteinebene für Optineurin Proteine (OPTN)

optineurin , optineurin-like , E3-14.7K-interacting protein , FIP-2 , HIP-7 , Huntingtin interacting protein L , huntingtin yeast partner L , huntingtin-interacting protein 7 , huntingtin-interacting protein L , nemo-related protein , optic neuropathy-inducing protein , transcription factor IIIA-interacting protein , transcrption factor IIIA-interacting protein , tumor necrosis factor alpha-inducible cellular protein containing leucine zipper domains , 14.7K-interacting protein 2 , FIP-2-like protein , TFIIIA-INTP , ag9-C5

GENE ID SPEZIES
736417 Pan troglodytes
100144665 Xenopus (Silurana) tropicalis
100195260 Salmo salar
100219034 Taeniopygia guttata
100398129 Callithrix jacchus
100597487 Nomascus leucogenys
10133 Homo sapiens
246294 Rattus norvegicus
478003 Canis lupus familiaris
397011 Sus scrofa
534150 Bos taurus
71648 Mus musculus
336159 Danio rerio
496250 Xenopus laevis
374079 Gallus gallus
100172952 Pongo abelii
574252 Macaca mulatta
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