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Rat (Rattus) Prothrombin Protein expressed in Rat - ABIN491211
Rancourt, Veress, Ahmad, Hendry-Hofer, Rioux, Garlick, White: Tissue factor pathway inhibitor prevents airway obstruction, respiratory failure and death due to sulfur mustard analog inhalation. in Toxicology and applied pharmacology 2013
Prothrombin morpholino-injected zebrafish embryos yielded an early phenotype exhibiting severe abnormalities that later showed occasional bleeding
The great similarity of prothrombin among rhesus, human, and porcine confirm the great value of the pig-to-rhesus xenotransplantation model.
Platelet derived microparticles formed in sepsis are a potent inducer of thrombin generation via phosphatidylserine exposure, and activation of both the intrinsic and extrinsic pathway of coagulation.
These findings imply that a thrombin-pericyte interaction in the brain could be a significant mechanism responsible for blood-brain barrier dysfunction under obesity-associated diabetic conditions and thus could represent a therapeutic target for central nervous system complications of diabetes.
mutations were introduced into the endogenous fII gene, resulting in expression of prothrombin carrying 3 amino acid substitutions (R157A, R268A, and K281A) to limit activation events to yield only fIIa(Meizothrombin) Homozygous fII(MZ) mice are viable, express fII levels comparable with fII(Wild type) mice, and have reproductive success.
Biglycan (zeige BGN Proteine) plays a protective role during the progression of atherosclerosis in ApoE (zeige APOE Proteine)-deficient mice by inhibiting thrombin generation.
allosteric inhibitor SbO4L targets the glycoprotein Ibalpha (zeige GP1BA Proteine)-binding and heparin-binding site of thrombin
thrombin/PAR-1 (zeige MARK2 Proteine) interaction regulated MCP-1 (zeige CPT1B Proteine), TF, MCSF (zeige CSF1 Proteine) and IL-6 (zeige IL6 Proteine) production.
Observations illustrate the role of thrombin as a pleiotropic atherogenic molecule under conditions of hypercholesterolemia and suggest the utility of its inhibition with locally acting antithrombin (zeige SERPINC1 Proteine) nanoparticle therapeutics.
Thrombin-PAR1 (zeige F2R Proteine) signaling, via nitric oxide and EPCR (zeige PROCR Proteine), promotes hematopoietic stem cell (HSC (zeige FUT1 Proteine)) mobilization.
Primary tumor growth by colon cancer cells was reduced by reduction of circulating prothrombin. There were lower mitotic indices and invasiveness. This growth relied upon 2 targets of thrombin-mediated proteolysis, protease: PAR-1 and fibrinogen.
Thrombin promotes sustained signaling and inflammatory gene expression through the CDC25 (zeige CDC25C Proteine) and Ras-associating domains of phospholipase C epsilon (zeige PLCE1 Proteine).
Thrombin, via PAR1 (zeige MARK2 Proteine) activation, synergistically augments LPS (zeige IRF6 Proteine)-induced Human endometrial endothelial cells production of chemokines involved in immune cell recruitment and survival, suggesting a mechanism by which intrauterine abruption and bacterial infection may together be associated with an aggravated uterine inflammatory response.
Clinical significance of prothrombin G20210A mutation in homozygous patients.
The prevalence of FVL (zeige F5 Proteine) polymorphism (16.3 %) was higher in retinopathy of prematurity (ROP (zeige STXBP1 Proteine)) patients than control subjects in this Turkish cohort. We suggest a possible association of FVL (zeige F5 Proteine) mutation with ROP (zeige STXBP1 Proteine) at the end of the study.
Data suggest that, for all coagulation proteins tested (prothrombin, factor X, activated factor VII, activated protein C), tighter binding to lipid bilayers (lower Kd) is observed as the proportion of anionic phospholipid increases. These studies were conducted in high-throughput screening using phospholipid bilayers in nanodiscs with multiplexed silicon photonic sensor (micro-ring resonator) array technology.
Factor Va reduced by 100-fold the apparent Kd of myosin for factor Xa (zeige F10 Proteine) (Kd approximately 0.48 nM), primarily by reducing koff, indicating formation of a stable ternary complex of myosin:Xa:Va.
Over the first 500 s, approximately 92,000 molecules of thrombin were generated per surface TF molecule for the 250-mum-long coating.
EPCR (zeige PROCR Proteine) occupancy recruits G-protein coupled receptor kinase 5 (zeige GRK5 Proteine), thereby inducing beta-arrestin-2 (zeige ARRB2 Proteine) biased PAR1 (zeige MARK2 Proteine) signaling by both APC (zeige APC Proteine) and thrombin. In
Data suggest that subtilisin, a serine protease secreted by non-pathogenic bacterium Bacillus subtilis, induces plasma clotting by proteolytically activating prothrombin with single "non-canonical" cleavage at Ala470-Asn471 bond.
An in silico and in vitro approach to elucidate the impact of residues flanking the cleavage scissile bonds of FVIII (zeige F8 Proteine) by thrombin has been presented.
These studies clarify the role of PKCdelta (zeige PKCd Proteine) in endothelial cell cytoskeleton regulation.
the weaker rapid interaction between prothrombin and membranes is the most important in vivo when considering the activation of prothrombin at the cell surface.
novel pyranosic sulfated (zeige SULF1 Proteine) arabinan Ab1 exerts its anticoagulant activity on thrombin by a mechanism different from those found previously for other sulfated (zeige SULF1 Proteine) polysaccharides and glycosaminoglycans
Exogenous delivery of thrombin enhances microvascular collateral development in response to ischemic insult, and accelerates tissue reperfusion.
the signaling pathways of MAPK (zeige MAPK1 Proteine), MSK1 (zeige RPS6KA5 Proteine), and NF-kappaB (zeige NFKB1 Proteine) play important roles in thrombin-induced iNOS (zeige NOS2 Proteine) expression in alveolar macrophages
High glucose enhances smooth muscle cell responsiveness to thrombin through transcriptional upregulation of PAR-4, mediated via PKC and NFkappaB.
Thrombin induces a sustained contraction in the normal pulmonary artery, by activating PAR(1 (zeige F2R Proteine)) and thereby increasing the sensitivity of the myofilament to Ca(2 (zeige CA2 Proteine)+).
kinetic and structural analysis of interactions between thrombin and the Factor XIII (zeige UGDH Proteine) activation peptide
analysis of staphylocoagulase-mediated bovine prothrombin activation
thrombin and factor Xa (zeige F10 Proteine) diffusion along the heparin molecule explains the effects of extended heparin chain lengths
A comparison of recombinant thrombin to bovine thrombin as a hemostatic ancillary in patients undergoing peripheral arterial bypass and arteriovenous graft procedures.
thrombin stimulates transglutaminase activity in articular cartilage by directly cleaving factor XIII (zeige UGDH Proteine) and by receptor-mediated up-regulation of factor XIII (zeige UGDH Proteine) synthesis
In conclusion, thrombin activates pro-MMP-2 (zeige MMP2 Proteine) in the absence of elevated pro-MMP-2 (zeige MMP2 Proteine) expression and secretion in CSMCs, and thrombin induces CSMC mitogenesis involving its action on MMP-2 (zeige MMP2 Proteine)
Thrombin stimulates swine smooth muscle cell differentiation from peripheral blood mononuclear cells via protease-activated receptor-1, RhoA, and myocardin.
Coagulation factor II is proteolytically cleaved to form thrombin in the first step of the coagulation cascade which ultimately results in the stemming of blood loss. F2 also plays a role in maintaining vascular integrity during development and postnatal life. Mutations in F2 leads to various forms of thrombosis and dysprothrombinemia.
, cell division cycle 34 homolog
, serine protease
, ubiquitin-conjugating enzyme Cdc34
, ubiquitin-conjugating enzyme E2 R1
, mast cell chymase
, mast cell protease I
, coagulation factor 2
, prepro-coagulation factor II
, prothrombin B-chain
, C1 esterase
, complement C1s-A subcomponent
, complement component 1 subcomponent s-A
, complement component C1SA