anti-Human Coagulation Factor XII (Hageman Factor) Antikörper für Enzyme Immunoassay

Recommended Coagulation Factor XII (Hageman Factor) Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Coagulation Factor XII (Hageman Factor) (F12) Antikörper
  • HAE3
  • HAEX
  • HAF
  • FXII
  • coagulation factor XII (Hageman factor)
  • F12
Epitop
AA 13-43, N-Term
21
16
14
7
6
5
4
3
3
3
3
2
1
1
1
1
1
1
1
1
1
Reaktivität
Human
153
34
29
2
1
Wirt
Kaninchen
89
30
24
18
1
Klonalität
Polyklonal
Konjugat
Unkonjugiert
12
9
8
4
4
4
1
1
1
1
1
1
1
1
1
Applikation
Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
106
88
21
20
11
9
8
5
5
4
4
2
2
2
2
2
1
1
1
Hersteller
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Bilder

Produktnummer ABIN951608
407,00 €
Zzgl. Versandkosten 20,00 € und MWSt
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anti-Coagulation Factor XII (Hageman Factor) Antikörper für Enzyme Immunoassay mit den meisten Publikationen

Ähnliche anti-Coagulation Factor XII (Hageman Factor) Antikörper

Applikation / Reaktivität Human
ELISA 81 Antikörper
ELISA (Capture) 1 Antikörper
ELISA (Detection) 5 Antikörper
Enzyme Immunoassay (EIA) 9 Antikörper
Functional Studies (Func) 2 Antikörper
Immunochromatography (IC) 1 Antikörper
Immunocytochemistry (ICC) 3 Antikörper
Immunodiffusion (ID) 5 Antikörper
Immunoelectrophoresis (IEP) 4 Antikörper
Immunofluorescence (IF) 2 Antikörper
Immunofluorescence (fixed cells) (IF/ICC) 1 Antikörper
Immunofluorescence (Paraffin-embedded Sections) (IF (p)) 11 Antikörper
Immunohistochemistry (IHC) 19 Antikörper
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) 21 Antikörper
Immunoprecipitation (IP) 8 Antikörper
Neutralization (Neut) 1 Antikörper
Proximity Ligation Assay (PLA) 2 Antikörper

General

Antigen Coagulation Factor XII (Hageman Factor) (F12) Antikörper
Epitop AA 13-43, N-Term
(21), (16), (14), (7), (6), (5), (4), (3), (3), (3), (3), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reaktivität Human
(153), (34), (29), (2), (1)
Wirt Kaninchen
(89), (30), (24), (18), (1)
Klonalität
Polyklonal
Konjugat Unkonjugiert
(12), (9), (8), (4), (4), (4), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation Enzyme Immunoassay (EIA), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(106), (88), (21), (20), (11), (9), (8), (5), (5), (4), (4), (2), (2), (2), (2), (2), (1), (1), (1)
Pubmed 7 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails

Antigendetails Anwendungsinformationen Handhabung Referenzen Bilder
Spezifität This antibody recognizes Human Coagulation factor XII (F12) (N-term).
Reinigung Affinity Chromatography on Protein A
Immunogen KLH conjugated synthetic peptide between 13~43 amino acids from the N-terminal region of human F12
Isotyp Ig

Antigendetails

Produktdetails Anwendungsinformationen Handhabung Referenzen Bilder zurück nach oben
Antigen
Andere Bezeichnung Coagulation Factor XII (F12) (F12 Antibody Abstract)
Hintergrund This gene encodes coagulation factor XII which circulates in blood as a zymogen. This single chain zymogen is converted to a two-chain serine protease with an heavy chain (alpha-factor XIIa) and a light chain. The heavy chain contains two fibronectin-type domains, two epidermal growth factor (EGF)-like domains, a kringle domain and a proline-rich domain, whereas the light chain contains only a catalytic domain. On activation, further cleavages takes place in the heavy chain, resulting in the production of beta-factor XIIa light chain and the alpha-factor XIIa light chain becomes beta-factor XIIa heavy chain. Prekallikrein is cleaved by factor XII to form kallikrein, which then cleaves factor XII first to alpha-factor XIIa and then to beta-factor XIIa. The active factor XIIa participates in the initiation of blood coagulation, fibrinolysis, and the generation of bradykinin and angiotensin. It activates coagulation factors VII and XI.Synonyms: HAF, Hageman factor
Molekulargewicht 67818 Da
Gen-ID 2161
NCBI Accession NP_000496
Pathways Komplementsystem

Anwendungsinformationen

Produktdetails Antigendetails Handhabung Referenzen Bilder zurück nach oben
Applikationshinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails Antigendetails Anwendungsinformationen Referenzen Bilder zurück nach oben
Format Liquid
Konzentration 0.25 mg/mL
Buffer PBS containing 0.09 % (W/V) Sodium Azide as preservative
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Handhabung Avoid repeated freezing and thawing.
Lagerung 4 °C/-20 °C
Informationen zur Lagerung Store undiluted at 2-8 °C for one month or (in aliquots) at -20 °C for longer.

Referenzen

Produktdetails Antigendetails Anwendungsinformationen Handhabung Bilder zurück nach oben
Allgemeine Veröffentlichungen

Houlihan, Davies, Tenesa, Harris, Luciano, Gow, McGhee, Liewald, Porteous, Starr, Lowe, Visscher, Deary: "Common variants of large effect in F12, KNG1, and HRG are associated with activated partial thromboplastin time." in: American journal of human genetics, Vol. 86, Issue 4, pp. 626-31, 2010

Katakami, Takahara, Kaneto, Shimizu, Ohno, Ishibashi, Osonoi, Kashiwagi, Kawamori, Shimomura, Matsuhisa, Yamasaki: "Accumulation of gene polymorphisms related to plaque disruption and thrombosis is associated with cerebral infarction in subjects with type 2 diabetes." in: Diabetes Care, Vol. 33, Issue 2, pp. 390-5, 2010

Bäck, Sanchez, Elgue, Ekdahl, Nilsson: "Activated human platelets induce factor XIIa-mediated contact activation." in: Biochemical and biophysical research communications, Vol. 391, Issue 1, pp. 11-7, 2010

Joseph, Tholanikunnel, Kaplan: "Treatment of episodes of hereditary angioedema with C1 inhibitor: serial assessment of observed abnormalities of the plasma bradykinin-forming pathway and fibrinolysis." in: Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology, Vol. 104, Issue 1, pp. 50-4, 2010

Calafell, Almasy, Sabater-Lleal, Buil, Mordillo, Ramírez-Soriano, Sikora, Souto, Blangero, Fontcuberta, Soria: "Sequence variation and genetic evolution at the human F12 locus: mapping quantitative trait nucleotides that influence FXII plasma levels." in: Human molecular genetics, Vol. 19, Issue 3, pp. 517-25, 2009

Bunkenborg, Pilch, Podtelejnikov, Wi?niewski: "Screening for N-glycosylated proteins by liquid chromatography mass spectrometry." in: Proteomics, Vol. 4, Issue 2, pp. 454-65, 2004

Hiller, Lichte, Oberpichler, Kocourek, Tschesche: "Matrix metalloproteinases collagenase-2, macrophage elastase, collagenase-3, and membrane type 1-matrix metalloproteinase impair clotting by degradation of fibrinogen and factor XII." in: The Journal of biological chemistry, Vol. 275, Issue 42, pp. 33008-13, 2000

Bilder

Produktdetails Antigendetails Anwendungsinformationen Handhabung Referenzen zurück nach oben
Bilder des Herstellers
Western Blotting (WB) image for anti-Coagulation Factor XII (Hageman Factor) (F12) (AA 13-43), (N-Term) Antikörper (ABIN951608) Western blot analysis of F12 Antibody (N-term) in K562,CEM,MDA-MB435 cell line lysate...