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anti-Complement Factor H (CFH) Antikörper

Bezeichnung:
anti-Complement Factor H Antikörper (CFH)
Auf www.antikoerper-online.de finden Sie aktuell 257 Complement Factor H (CFH) Antikörper von 26 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen Complement Factor H Kits (56) und Complement Factor H Proteine (19) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 341 Complement Factor H Produkte verfügbar.
Synonyme:
AHUS1, AMBP1, ARMD4, ARMS1, CFH, CFHL3, fH, FHL1, HF, HF1, HF2, HUS, im:7147412, Mud-1, NOM, Sas-1, Sas1, si:ch211-207o17.2

Meistgesuchte Reaktivitäten zu anti-Complement Factor H (CFH) Antikörper

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anti-Mouse (Murine) Complement Factor H Antikörper:

anti-Human Complement Factor H Antikörper:

anti-Rat (Rattus) Complement Factor H Antikörper:

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Am meisten referenzierte anti-Complement Factor H Antikörper

  1. Human Monoclonal Complement Factor H Primary Antibody für FACS - ABIN2660858 : Ripoche, Day, Harris, Sim: The complete amino acid sequence of human complement factor H. in The Biochemical journal 1988 (PubMed)
    Zeige alle 6 Referenzen für ABIN2660858

  2. Human Polyclonal Complement Factor H Primary Antibody für EIA, IF - ABIN951646 : Dieterich, Hammerschmidt, Richter, Skerka, Wallich, Matuschka, Zipfel, Kraiczy: Inadequate binding of immune regulator factor H is associated with sensitivity of Borrelia lusitaniae to human complement. in Infection and immunity 2010 (PubMed)
    Zeige alle 3 Referenzen für ABIN951646

  3. Human Monoclonal Complement Factor H Primary Antibody für EIA, FACS - ABIN181114 : Alexander, Quigg: The simple design of complement factor H: Looks can be deceiving. in Molecular immunology 2006 (PubMed)
    Zeige alle 2 Referenzen für ABIN181114

  4. Human Polyclonal Complement Factor H Primary Antibody für IF, IHC (p) - ABIN654896 : Scambi, La Verde, De Franceschi, Barausse, Poli, Benedetti, Sorio, Deriu, Roncada, Bortolami, Turrini, Caramaschi, Stranieri, Bambara, Biasi: Comparative proteomic analysis of serum from patients with systemic sclerosis and sclerodermatous GVHD. Evidence of defective function of factor H. in PLoS ONE 2010 (PubMed)
    Zeige alle 2 Referenzen für ABIN654896

  5. Horse (Equine) Polyclonal Complement Factor H Primary Antibody für EIA, ID - ABIN113017 : Chung, Liszewski, Nybakken, Davis, Townsend, Fremont, Atkinson, Diamond: West Nile virus nonstructural protein NS1 inhibits complement activation by binding the regulatory protein factor H. in Proceedings of the National Academy of Sciences of the United States of America 2006 (PubMed)

  6. Human Polyclonal Complement Factor H Primary Antibody für ELISA, WB - ABIN250548 : Klein, Zeiss, Chew, Tsai, Sackler, Haynes, Henning, SanGiovanni, Mane, Mayne, Bracken, Ferris, Ott, Barnstable, Hoh: Complement factor H polymorphism in age-related macular degeneration. in Science (New York, N.Y.) 2005 (PubMed)

Weitere Antikörper gegen Complement Factor H Interaktionspartner

Chimpanzee Complement Factor H (CFH) Interaktionspartner

  1. interaction between sialylated Neisseria gonorrhoeae and factor H [factor H]

Zebrafish Complement Factor H (CFH) Interaktionspartner

  1. Results report the molecular cloning and identification of complement factor H and complement factor H-like 1-4 (CFHL1 (zeige CFHR1 Antikörper)-4) in Danio rerio.

Mouse (Murine) Complement Factor H (CFH) Interaktionspartner

  1. environmental factors can drive retinal disease in these mice when linked to complement deficits impairing immune function. Both groups of mice had similar levels of retinal amyloid beta accumulation. Consequently there is no direct link between this and inflammation in Cfh(-/-) mice.

  2. absence of plasma CfH conferred susceptibility to glomerulonephritis

  3. This new understanding of the complicated interactions of CFH in AMD (zeige AMD1 Antikörper)-like pathology provides an improved foundation for the development of targeted therapies for AMD (zeige AMD1 Antikörper)

  4. data suggest that altered interactions of Cfh with MDA-modified proteins may be relevant in explaining the effects of the Cfh variant.

  5. Cfh and Cfhr2 (zeige CFHR2 Antikörper) genes are expressed in the mouse outer retina. Only Cfh mRNA was detected in the retinal pigment epithelium, but no protein.

  6. A spectrum of complement dysregulation was modeled on the APOE4 age related macular degeneration mouse model by crossing these mice to complement factor H knockout (cfh-/-) mice to test the impact of excess complement activation.

  7. Data indicate that co-deficiency of factor H (FH) and MASP-1/MASP-3 (zeige MASP1 Antikörper) did not ameliorate either the plasma Complement C3 (zeige C3 Antikörper) (C3) activation or glomerular C3 accumulation in FH-deficient mice.

  8. A2E accumulation altered retinal microglial complement regulation by decreasing complement factor H (and increasing complement factor B (zeige CFB Antikörper) expression), favoring increased complement activation and lipofuscin deposition in the outer retina.

  9. The exaggerated humoral immune response in CFH(-/-) mice was normalized in CFH(-/-)C5aR (zeige C5AR1 Antikörper)(-/-) double knockout mice, highlighting the C5aR (zeige C5AR1 Antikörper) dependence.

  10. Properdin (zeige CFB Antikörper) deficiency exacerbated renal injury in mice lacking complement factor H.

Human Complement Factor H (CFH) Interaktionspartner

  1. Our results show that age-related macular degeneration donors carrying the high risk allele for CFH (C) had significantly more mtDNA damage compared with donors having the wild-type genetic profile.

  2. Data suggest that Staphylococcus aureus surface protein SdrE (serine-aspartate repeat protein E (zeige CRISP1 Antikörper)) functions as a 'clamp (zeige PDZK1 Antikörper)' to capture C-terminal tail of human CFH (complement factor H) at a specific ligand-binding site/groove via unique close-dock-lock-latch mechanism and thereby sequesters CFH on surface of S. aureus for complement evasion (immune evasion).

  3. The haplotypic coinheritance of potentially functional variants (including missense variants, novel splice sites, and the CFHR3 (zeige CFHR3 Antikörper)-CFHR1 (zeige CFHR1 Antikörper) deletion) was described for the four common haplotypes. Expression of the short and long CFH transcripts differed markedly between the retina and liver.

  4. Data suggest that complement factor H (CFH) attaches to surface of host cells to inhibit complement activation and amplification, preventing destruction of the host cells; SdrE (serine-aspartate repeat protein) of Staphylococcus aureus binds to CFH allowing S. aureus to mimic a host cell and reducing bacterial killing by granulocytes. [Commentary]

  5. Interaction effects between supplement groups and individual complement factor H (CFH) Y402H and age-related maculopathy susceptibility 2 (ARMS2 (zeige ARMS2 Antikörper)) genotypes, and composite genetic risk groups combining the number of risk alleles for both loci, were evaluated for their association with progression

  6. EMD (zeige EMD Antikörper) were not AMD (zeige AMD1 Antikörper)-independently associated with CFH or ARMS2 (zeige ARMS2 Antikörper) genotypes. Our results indicate that patients without AMD (zeige AMD1 Antikörper) but with EMD (zeige EMD Antikörper) can serve as controls in studies evaluating AMD (zeige AMD1 Antikörper) risk factors.

  7. Despite limited power of this pilot study, our results suggest an association of HF with polymorphisms in ARMS2 (zeige ARMS2 Antikörper)/HTRA1 (zeige HTRA1 Antikörper), CFH, APOE4/TOMM40 (zeige TOMM40 Antikörper), and VEGFA (zeige VEGFA Antikörper) genes which could be triggered by modification of the extracellular matrix, altered complement system or lipid metabolism.

  8. data suggest that R1210C is a unique C-terminal complement factor H mutation that behaves as a partial complement factor H deficiency, predisposing individuals to diverse pathologies with distinct underlying pathogenic mechanisms; the final disease outcome is then determined by R1210C-independent genetic risk factors

  9. AMD (zeige AMD1 Antikörper) progression rate is influenced by CFH, and suggest that variants within CFH may have different effects on risk versus progression. However, since CFH:rs10737680 was not significant after Bonferroni correction and explained only a relatively small portion of variation in progression rate beyond that explained by age

  10. We describe a novel CFH/CFHR3 (zeige CFHR3 Antikörper) hybrid gene secondary to a de novo 6.3-kb deletion that arose through microhomology-mediated end joining rather than nonallelic homologous recombination. We confirmed a transcript from this hybrid gene and showed a secreted protein product that lacks the recognition domain of factor H and exhibits impaired cell surface complement regulation

Pig (Porcine) Complement Factor H (CFH) Interaktionspartner

Complement Factor H (CFH) Antigen-Profil

Beschreibung des Gens

This gene is a member of the Regulator of Complement Activation (RCA) gene cluster and encodes a protein with twenty short consensus repeat (SCR) domains. This protein is secreted into the bloodstream and has an essential role in the regulation of complement activation, restricting this innate defense mechanism to microbial infections. Mutations in this gene have been associated with hemolytic-uremic syndrome (HUS) and chronic hypocomplementemic nephropathy. Alternate transcriptional splice variants, encoding different isoforms, have been characterized.

Alternative names and synonyms associated with Complement Factor H (CFH)

  • complement factor H (CFH) Antikörper
  • complement factor H (cfh) Antikörper
  • complement component factor h (Cfh) Antikörper
  • complement factor H (Cfh) Antikörper
  • AHUS1 Antikörper
  • AMBP1 Antikörper
  • ARMD4 Antikörper
  • ARMS1 Antikörper
  • CFH Antikörper
  • CFHL3 Antikörper
  • fH Antikörper
  • FHL1 Antikörper
  • HF Antikörper
  • HF1 Antikörper
  • HF2 Antikörper
  • HUS Antikörper
  • im:7147412 Antikörper
  • Mud-1 Antikörper
  • NOM Antikörper
  • Sas-1 Antikörper
  • Sas1 Antikörper
  • si:ch211-207o17.2 Antikörper

Bezeichner auf Proteinebene für CFH

complement factor H , complement factor H related protein 3A4/5G4 , protein beta-1-H , H factor 1 (complement) , H factor 2 (complement) , adrenomedullin binding protein , age-related maculopathy susceptibility 1 , beta-1-H-globulin , beta-1H , factor H , factor H-like 1 , complement component factor H , complement inhibitory factor H , platelet complement factor H , complement regulator factor H

GENE ID SPEZIES
457601 Pan troglodytes
553060 Danio rerio
553297 Danio rerio
100399888 Callithrix jacchus
100451270 Pongo abelii
100465619 Ailuropoda melanoleuca
100600041 Nomascus leucogenys
12628 Mus musculus
3075 Homo sapiens
100051358 Equus caballus
155012 Rattus norvegicus
478952 Canis lupus familiaris
100733902 Cavia porcellus
100340175 Oryctolagus cuniculus
397525 Sus scrofa
280816 Bos taurus
429057 Gallus gallus
100174982 Ovis aries
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