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Neural crest cells are coattracted via the complement fragment C3a and its receptor C3aR (zeige C3AR1 Proteine), revealing an unexpected role of complement proteins in early vertebrate development.
Time-lapse video microscopy established the localization of the complement anaphylatoxin C3a and its receptor on enteric neural crest cells during their migration in the embryonic gut (zeige GUSB Proteine). C3a plays a role in regulating collective and directional cell migration, and in ganglia network organization during enteric nervous system ontogenesis. It regulates cell migration in a N-cadherin (zeige CDH2 Proteine)-dependent process.
Retinal C3 was expressed by microglia/macrophages located in the outer retina in AMD (zeige AMD1 Proteine) eyes. In rodent photo-oxidative damage, C3-expressing microglia/macrophages and complement activation were located in regions of lesion expansion in the outer retina over 2 months
Demonstrate local synthesis of complement proteins by both PDGFRbeta-positive pericytes and CD45 (zeige PTPRC Proteine)-positive cells in kidney fibrosis.
Wild-type C57BL/6 mice with pristane-induced lupus developed a strong IFN signature, which was absent in immunoglobulin-deficient (muMT), C3(-/-) , and CD18 (zeige ITGB2 Proteine)(-/-) mice. In vivo phagocytosis of dead cells was impaired in C3-deficient mice.
Study found that cancer-cell-derived C3 activates the C3a receptor in the choroid plexus epithelium to disrupt the blood-cerebrospinal fluid (CSF (zeige CSF2 Proteine)) barrier. This effect allows plasma components, including amphiregulin (zeige AREG Proteine), and other mitogens to enter the CSF (zeige CSF2 Proteine) and promote cancer cell growth.
We induced anti-myeloperoxidase (zeige MPO Proteine) vasculitis in mice and confirmed a role for complement activation by demonstrating protection in C3-deficient mice.
These data indicated that alpha7-nAChR (zeige CHRNA7 Proteine) caused the inhibition of ASPinduced activation of p38 (zeige CRK Proteine) kinase and NFkappa B to inhibit the production of MCP1 (zeige CCL2 Proteine) and keratinocytederived chemokine (zeige CCL1 Proteine).
This study provideed the evidence that C3a plays a critical role in cerebral endothelial activation and leukocyte recruitment during inflammation in the brain.
Demonstrate that cardiac Sirt1 (zeige SIRT1 Proteine) plays an essential role in caloritc restriction-induced cardioprotection against myocardial I/R injury by suppressing cardiac C3 expression.
The roles of C3, CfB (zeige CFB Proteine), and C3a receptor in the severity of S. aureus induced septic arthritis are reported.
This study uncovers the origin of the effect of ionic strength on C3d-CR2 interaction and deepens the understanding of the molecular mechanism of their interaction, which is valuable for the design of vaccines and small molecule inhibitors.
Studies indicate that the complement response lie the active fragments, C3a and C5a, acting through their specific receptors, C3aR (zeige C3AR1 Proteine), C5aR1 (zeige C5AR1 Proteine) and C5aR2 to direct the cellular response to inflammation.
exposure of neural stem cells to neutrophil-synthesized concentrations of C1q and C3a promoted astrogliogenesis and cell migrationtion.
THP (zeige UMOD Proteine) appears to participate directly in complement inactivation by its ability to act as a cofactor for C3b degradation.
Decreased C5a expression is associated with increased inflammation in cystic fibrosis (zeige S100A8 Proteine).
C3d-positive glomerular staining is an independent risk factor for the development of end-stage renal disease in ANCA-associated renal vasculitis.
Factor I binds C3b-Factor H (zeige CFH Proteine) between Factor H (zeige CFH Proteine) domains 2 and 3 and a reoriented C3b C-terminal domain and docks onto the first scissile bond, while stabilizing its catalytic domain for proteolytic activity.
The VEGF (zeige VEGFA Proteine) haplotype TGA (zeige TBX1 Proteine) could be used as a marker for poor visual prognosis in Tunisian patients with neovascular AMD (zeige AMD1 Proteine) treated with bevacizumab.
The uromodulin (zeige UMOD Proteine)-CFH (zeige CFH Proteine) interaction enhanced the cofactor activity of CFH (zeige CFH Proteine) for factor I-mediated cleavage of C3b to inactivated C3b.
Generated monoclonal antibody that can only bind to C3d when it manifests itself as the final end product of cleaved C3.
Complement component C3 plays a central role in the activation of complement system. Its activation is required for both classical and alternative complement activation pathways. People with C3 deficiency are susceptible to bacterial infection.
, complement component 3
, acylation stimulating protein
, complement C3
, complement component 3d
, complement factor 3
, C3 and PZP-like alpha-2-macroglobulin domain-containing protein 1
, C3a anaphylatoxin
, acylation-stimulating protein cleavage product
, complement component C3
, complement component C3a
, complement component C3b
, complement C3 alpha chain
, complement component C3d