Die folgenden Gennamen und Gensymbole werden für Antigen Presenilin 1 über verschiedene Spezies hinweg verwendet:

presenilin 1 (PSEN1), presenilin 1 (Psen1), presenilin (psen1), presenilin 1 (psen1), presenilin 1 (Alzheimer disease 3) (PSEN1)

Zu den weiteren Synonymen zählen:

AD3, FAD, PS1, S182, Ad3h, PS-1, pre1, psen, zfPS1, zf-PS1, PSEN1, ad3, fad, ps1, s182, X-PS-beta, X-PS-alpha, DKFZp469K2026

Auf Proteinebene tauchen folgende Bezeichner für Antigen Presenilin 1 auf:

presenilin 1 – OTTHUMP00000180589 – presenilin-1 – PS-1 – presenilin 1 (Alzheimer disease 3) – Presenilin-1 – presenilin-1-like

Presenilin 1 erfüllt eine Reihe von Funktionen:

PDZ domain binding – beta-catenin binding – endopeptidase activity – peptidase activity – cadherin binding – hydrolase activity – protein binding – calcium channel activity

Presenilin 1 spielt in den folgenden Prozessen eine Rolle:

Notch receptor processing – amyloid precursor protein catabolic process – anti-apoptosis – apoptosis – cell death – cell-cell adhesion – chromosome segregation – endoplasmic reticulum calcium ion homeostasis – induction of apoptosis by extracellular signals – intracellular signaling cascade – membrane protein ectodomain proteolysis – membrane protein intracellular domain proteolysis – positive regulation of catalytic activity – protein processing – regulation of phosphorylation – Cajal-Retzius cell differentiation – L-glutamate transport – Notch signaling pathway – T cell activation involved in immune response – T cell receptor signaling pathway – activation of MAPKK activity – anagen – autophagic vacuole assembly – autophagy – beta-amyloid metabolic process – blood vessel development – brain development – brain morphogenesis – cell adhesion – cell fate specification – cellular calcium ion homeostasis – cellular protein metabolic process – cerebral cortex cell migration – cerebral cortex development – choline transport – dorsal/ventral neural tube patterning – embryo development – embryonic limb morphogenesis – epithelial cell proliferation – forebrain development – heart development – heart looping – hemopoietic progenitor cell differentiation – intracellular signaling pathway – learning or memory – locomotion – memory – mitochondrial transport – myeloid leukocyte differentiation – negative regulation of axonogenesis – negative regulation of neuron apoptosis – negative regulation of protein amino acid phosphorylation – negative regulation of protein kinase activity – neurogenesis – neuron apoptosis – neuron development – neuron differentiation – neuron migration – positive regulation of MAP kinase activity – positive regulation of apoptosis – positive regulation of coagulation – positive regulation of protein amino acid phosphorylation – positive regulation of protein kinase activity – post-embryonic development – protein amino acid glycosylation – protein maturation – protein maturation by peptide bond cleavage – protein transport – regulation of epidermal growth factor receptor activity – regulation of protein binding – regulation of resting membrane potential – regulation of synaptic plasticity – regulation of synaptic transmission, glutamatergic – response to DNA damage stimulus – response to oxidative stress – segmentation – skeletal system morphogenesis – smooth endoplasmic reticulum calcium ion homeostasis – somitogenesis – synaptic vesicle targeting – thymus development – eye photoreceptor cell development – T cell activation during immune response – autophagic vacuole formation – embryonic development

Presenilin 1 ist wie folgt lokalisiert:

Golgi apparatus – cell surface – endoplasmic reticulum – integral to nuclear inner membrane – integral to plasma membrane – kinetochore – membrane fraction – mitochondrion – nuclear outer membrane – plasma membrane – axon – ciliary rootlet – cytoplasmic vesicle – dendrite – dendritic shaft – growth cone – integral to membrane – intracellular – lysosomal membrane – membrane – membrane raft – membrane-bounded organelle – mitochondrial inner membrane – neuromuscular junction – neuronal cell body – nucleus – protein complex – synaptosome – Golgi membrane – centrosome – endoplasmic reticulum membrane – gamma-secretase complex – nuclear membrane – rough endoplasmic reticulum – smooth endoplasmic reticulum – intrinsic to membrane – cell soma

Quelle: NCBI Entrez Gene, Gene Ontology