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anti-Human TYK2 Antikörper:
anti-Mouse (Murine) TYK2 Antikörper:
anti-Rat (Rattus) TYK2 Antikörper:
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Human Monoclonal TYK2 Primary Antibody für IF, IP - ABIN967792
Blesofsky, Mowen, Arduini, Baker, Murphy, Bowtell, David: Regulation of STAT protein synthesis by c-Cbl. in Oncogene 2001
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Human Monoclonal TYK2 Primary Antibody für IF, IP - ABIN967793
Masuda, Matsuguchi, Yamaki, Hayakawa, Kubo, LaRochelle, Yoshikai: Interleukin-15 induces rapid tyrosine phosphorylation of STAT6 and the expression of interleukin-4 in mouse mast cells. in The Journal of biological chemistry 2000
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Human Monoclonal TYK2 Primary Antibody für ELISA, WB - ABIN967218
Shaw, Freeman, Scott, Fox, Bzik, Belkaid, Yap: Tyk2 negatively regulates adaptive Th1 immunity by mediating IL-10 signaling and promoting IFN-gamma-dependent IL-10 reactivation. in Journal of immunology (Baltimore, Md. : 1950) 2006
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Human Polyclonal TYK2 Primary Antibody für IHC - ABIN967219
Gauzzi, Velazquez, McKendry, Mogensen, Fellous, Pellegrini: Interferon-alpha-dependent activation of Tyk2 requires phosphorylation of positive regulatory tyrosines by another kinase. in The Journal of biological chemistry 1996
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Human Monoclonal TYK2 Primary Antibody für ELISA, WB - ABIN969448
Seto, Nakajima, Suto, Shimoda, Saito, Nakayama, Iwamoto: Enhanced Th2 cell-mediated allergic inflammation in Tyk2-deficient mice. in Journal of immunology (Baltimore, Md. : 1950) 2003
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Human Polyclonal TYK2 Primary Antibody für ICC, IF - ABIN4363628
Forsström, Axnäs, Stengele, Bühler, Albert, Richmond, Hu, Nilsson, Hudson, Rockberg, Uhlen: Proteome-wide epitope mapping of antibodies using ultra-dense peptide arrays. in Molecular & cellular proteomics : MCP 2014
High TYK2 expression is associated with B-cell lymphoma.
These data indicate that germline activating TYK2 mutations predispose to the development of ALL.
TYK2 rs280519 genotype was significantly related to severe necroinflammatory activity (NIA) grade of chronic hepatitis C patients.
TYK2 is associated with systemic sclerosis susceptibility and reinforce the relevance of the IL-12 (zeige IL12A Antikörper) pathway in SSc (zeige CYP11A1 Antikörper) pathophysiology.
Clinical genomic analysis of the current series of NF1 (zeige NF1 Antikörper)-MPNST cases found that TYK2 is a new gene mutated in MPNST.
Results demonstrates that the TYK2 rs2304256 and rs12720356 polymorphisms are associated with susceptibility to rheumatic diseases, rs2304256 polymorphism is associated with systemic lupus erythematous (SLE) in Caucasians, and rs280519 polymorphism is associated with SLE in Caucasians and Asians. [meta-analysis]
demonstration of the single marker association of tyrosine kinase-2 polymorphisms with ulcerative colitis and Crohn's disease in Turkish population.
The TYK2 promoter variant is associated with an overall risk for diabetes.
Genetic associations and gene-gene interactions of IRF5 and TYK2 were significantly detected in Han Chinese with systemic lupus erythematosus
the role of TYK2 in the pathogenesis of rheumatoid arthritis
Results show that loss of TYK2 does not affect disease severity of JAK2VF-induced murine myeloproliferative neoplasms (MPN (zeige PRSS27 Antikörper)) indicating that TYK2 has no cooperative effects with JAK2VF at the onset of MPN (zeige PRSS27 Antikörper).
mutated form which lacks tyrosine kinase (zeige TYRO3 Antikörper) activity restores differentiation of brown preadipocytes
Decreased Tyk2 expression in pancreatic beta cells due to mutation determines susceptibility to virus-induced diabetes mellitus.
Tyk2 protects against acute colitis in part by amplifying inflammation-induced epithelial IL-22 (zeige IL22 Antikörper) signaling to STAT3 (zeige STAT3 Antikörper)
A reduced survival fitness of the Th17 in the absence of Tyk-2 mediated by the up-regulation of SOCS3 (zeige SOCS3 Antikörper).
Data indicate the important role of Tyk2 in skin inflammation and the therapeutic potential of Tyk2 inhibition in psoriasis.
The conditional Tyk2 mouse strain will be instrumental to further dissect TYK2 functions in infection, inflammation and cancer.
In cellular assays, SAR (zeige SRL Antikörper)-20347 dose dependently (1 nM-10 muM) inhibited JAK1 (zeige JAK1 Antikörper)- and/or TYK2-dependent signaling from the IL-12 (zeige IL12A Antikörper)/IL-23 (zeige IL23A Antikörper), IL-22 (zeige IL22 Antikörper), and IFN-alpha (zeige IFNA Antikörper) receptors.
this report identifies Tyk2 as a prerequisite factor in the molecular networks that are involved in generation of IL-27 (zeige IL27 Antikörper).
Tyk2-mediated IL-12 (zeige IL12A Antikörper) signaling is differentially required for the development of different Th1 (zeige HAND1 Antikörper) cell subsets but similarly induces their bystander IFN-gamma (zeige IFNG Antikörper) production
This gene encodes a member of the tyrosine kinase and, more specifically, the Janus kinases (JAKs) protein families. This protein associates with the cytoplasmic domain of type I and type II cytokine receptors and promulgate cytokine signals by phosphorylating receptor subunits. It is also component of both the type I and type III interferon signaling pathways. As such, it may play a role in anti-viral immunity. A mutation in this gene has been associated with hyperimmunoglobulin E syndrome (HIES) - a primary immunodeficiency characterized by elevated serum immunoglobulin E.
non-receptor tyrosine-protein kinase TYK2
, tyrosine kinase TYK2
, non-receptor tyrosine kinase Tyk2