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The full length cDNA sequence of Atlantic salmon (Salmo salar) ssSTAT2 was determined and phylogenetic analysis of the amino acid sequence grouped this novel salmon gene to the STAT2 clade.
this study shows that STAT2 plays a critical role in TLR-induced dendritic cell activation and cross-presentation, and
this study shows that STAT2 plays a critical role in TLR-induced dendritic cell activation and cross-presentation
these studies identify phosphorylation of S734-STAT2 as a new regulatory mechanism that negatively controls the type I IFN-antiviral response.
IFN-I can mediate ISG expression inmixed glial cell cultures (MGCs) via ISGF3 (zeige IRF9 Proteine)-independent signaling pathways but with reduced efficiency, with delayed and prolonged kinetics, and is more dependent on STAT1 (zeige STAT1 Proteine) and STAT2 than IRF9 (zeige IRF9 Proteine); and 2) signaling pathways not involving STAT1 (zeige STAT1 Proteine), STAT2, or IRF9 (zeige IRF9 Proteine) play a minor role only in mediating IFN-alpha (zeige IFNA Proteine)-stimulated genes expression in MGCs.
transcriptional activation of Adar1 (zeige ADAR Proteine) by IFN occurs in the absence of STAT1 (zeige STAT1 Proteine) by a non-canonical STAT2-dependent pathway in mouse but not human cells.
IFN-alpha (zeige IFNA Proteine)/beta is able to drive the formation of a Stat2 and IRF-9 (zeige IRF9 Proteine) complex that drives the expression of a subset of IFN-stimulated genes, but with substantially delayed kinetics.
Activation of STAT2/IRF9 (zeige IRF9 Proteine) induces a prolonged ISGF3 (zeige IRF9 Proteine)-like transcriptome and generates an antiviral response.
In a mouse syngeneic tumor transplantation model STAT2 expression reduces tumor growth.
Data suggest a role for Vc in Nanog regulation networks and reveal a novel role for STAT2 in regulating Nanog expression.
Stat2 loss leads to reduced expression of NF-kappaB (zeige NFKB1 Proteine) target genes by affecting nuclear translocation of NF-kappaB (zeige NFKB1 Proteine).
data suggest that STAT2 plays a role in the psoriasis pathogenesis by regulating the expression of CXCL11 (zeige CXCL11 Proteine) and CCL5 (zeige CCL5 Proteine), and thereby attracting IFNgamma-producing immune cells to the skin
Interferon-alpha-enhanced IL-10 expression in human CD4 T cells is regulated by STAT3, STAT2, and BATF transcription factors.
the rate-limiting transition state for binding between the TAZ1 (zeige TAZ Proteine) domain of CREB binding protein (zeige CREBBP Proteine) and the intrinsically disordered transactivation domain of STAT2 (TAD (zeige CRTAM Proteine)-STAT2) by site-directed mutagenesis and kinetic experiments (Phi-value analysis) and found that the native protein-protein binding interface is not formed at the transition state for binding.
Data show that moringin (GMG-ITC) had a limited inhibitory effect on IFNalpha-induced STAT1 (zeige STAT1 Proteine) and STAT2 activity, indicating differentially targeting JAK (zeige JAK3 Proteine)/STAT (zeige STAT1 Proteine) signaling pathways.
study demonstrates that overexpression of Porcine deltacoronavirus (PDCoV) nsp5 (zeige SPECC1 Proteine) also antagonizes IFN signaling by cleaving STAT2, an essential component of transcription factor complex ISGF3 (zeige STAT1 Proteine), and that PDCoV infection reduces the levels of STAT2, which may affect the innate immune response
PKV VP3 associated with STAT2 and IRF9 (zeige IRF9 Proteine), and interfered with the formation of the STAT2-IRF9 (zeige IRF9 Proteine) and STAT2-STAT2 complex.
The authors have discovered a novel phosphorylation of STAT2 on T387 that negatively regulates signal from the type I interferon receptor (zeige IFNAR1 Proteine) to the genome by transcription factor ISGF3 (zeige STAT1 Proteine).
STAT2 recruits USP18 (zeige USP18 Proteine) to the type I IFN receptor subunit IFNAR2 (zeige IFNAR2 Proteine) via its constitutive membrane-distal STAT2-binding site.
These results establish that activation of STAT (zeige STAT1 Proteine) pathway is essential for anti-hepatitis c virus efficacy of IFN-alpha (zeige IFNA Proteine).
While La Piedad Michoacan Mexico Virus V protein does not affect the protein levels of STAT1 (zeige STAT1 Proteine) or STAT2, it does prevent the interferon (zeige IFNA Proteine)-induced phosphorylation and nuclear translocation of STAT1 (zeige STAT1 Proteine) and STAT2 thereby inhibiting cellular responses to interferon alpha (zeige IFNA Proteine)/beta.
Taken together, results of these experiments describe for the first time a novel mechanism by which foot-and-mouth disease virus evolves to inhibit IFN signaling via blocking STAT1 (zeige STAT1 Proteine)/STAT2 nuclear translocation.
Nsp1beta inhibits interferon-activated (zeige MNDA Proteine) STAT1 (zeige STAT1 Proteine)/STAT2 signal transduction by inducing karyopherin-alpha1 degradation.
the majority of the STAT1 (zeige STAT1 Proteine)/STAT2/IRF9 (zeige IRF9 Proteine) (IFN regulatory factor 9) heterotrimers remained in the cytoplasm of PRRSV-infected cells, which indicates that the nuclear translocation of the heterotrimers was blocked
Prolonged treatment with IFN-alpha (12-48 h) resulted in increased expression of STAT1 (zeige STAT1 Proteine) and, to a lesser extent, STAT2.
The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene.
, signal transducer and activator of transcription 2
, signal transducer and activator of transcription (AGAP000099-PA)
, interferon alpha induced transcriptional activator