STAT2 Proteine (STAT2)

Bezeichnung:
Signal Transducer and Activator of Transcription 2, 113kDa Proteine (STAT2)
Auf www.antikoerper-online.de finden Sie aktuell 10 Signal Transducer and Activator of Transcription 2, 113kDa (STAT2) Proteine von 6 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen STAT2 Antikörper (271) und STAT2 Kits (37) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 328 STAT2 Produkte verfügbar.
Synonyme:
1600010G07Rik, AW496480, ISGF-3, P113, stat2, STAT113, wu:fj84d07
alle Proteine anzeigen Gen GeneID UniProt
STAT2 20847  
STAT2 288774  
STAT2 6773 P52630

Weitere Synonyme anzeigen

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Weitere Proteine zu STAT2 Interaktionspartnern

Atlantic Salmon (Salmo salar) Signal Transducer and Activator of Transcription 2, 113kDa (STAT2) Interaktionspartner

  1. The full length cDNA sequence of Atlantic salmon (Salmo salar) ssSTAT2 was determined and phylogenetic analysis of the amino acid sequence grouped this novel salmon gene to the STAT2 clade.

Mouse (Murine) Signal Transducer and Activator of Transcription 2, 113kDa (STAT2) Interaktionspartner

  1. this study shows that STAT2 plays a critical role in TLR-induced dendritic cell activation and cross-presentation, and

  2. this study shows that STAT2 plays a critical role in TLR-induced dendritic cell activation and cross-presentation

  3. these studies identify phosphorylation of S734-STAT2 as a new regulatory mechanism that negatively controls the type I IFN-antiviral response.

  4. IFN-I can mediate ISG expression inmixed glial cell cultures (MGCs) via ISGF3 (zeige IRF9 Proteine)-independent signaling pathways but with reduced efficiency, with delayed and prolonged kinetics, and is more dependent on STAT1 (zeige STAT1 Proteine) and STAT2 than IRF9 (zeige IRF9 Proteine); and 2) signaling pathways not involving STAT1 (zeige STAT1 Proteine), STAT2, or IRF9 (zeige IRF9 Proteine) play a minor role only in mediating IFN-alpha (zeige IFNA Proteine)-stimulated genes expression in MGCs.

  5. transcriptional activation of Adar1 (zeige ADAR Proteine) by IFN occurs in the absence of STAT1 (zeige STAT1 Proteine) by a non-canonical STAT2-dependent pathway in mouse but not human cells.

  6. IFN-alpha (zeige IFNA Proteine)/beta is able to drive the formation of a Stat2 and IRF-9 (zeige IRF9 Proteine) complex that drives the expression of a subset of IFN-stimulated genes, but with substantially delayed kinetics.

  7. Activation of STAT2/IRF9 (zeige IRF9 Proteine) induces a prolonged ISGF3 (zeige IRF9 Proteine)-like transcriptome and generates an antiviral response.

  8. In a mouse syngeneic tumor transplantation model STAT2 expression reduces tumor growth.

  9. Data suggest a role for Vc in Nanog regulation networks and reveal a novel role for STAT2 in regulating Nanog expression.

  10. Stat2 loss leads to reduced expression of NF-kappaB (zeige NFKB1 Proteine) target genes by affecting nuclear translocation of NF-kappaB (zeige NFKB1 Proteine).

Human Signal Transducer and Activator of Transcription 2, 113kDa (STAT2) Interaktionspartner

  1. the rate-limiting transition state for binding between the TAZ1 (zeige TAZ Proteine) domain of CREB binding protein (zeige CREBBP Proteine) and the intrinsically disordered transactivation domain of STAT2 (TAD (zeige CRTAM Proteine)-STAT2) by site-directed mutagenesis and kinetic experiments (Phi-value analysis) and found that the native protein-protein binding interface is not formed at the transition state for binding.

  2. these studies identify phosphorylation of S734-STAT2 as a new regulatory mechanism that negatively controls the type I IFN-antiviral response.

  3. Data show that moringin (GMG-ITC) had a limited inhibitory effect on IFNalpha-induced STAT1 (zeige STAT1 Proteine) and STAT2 activity, indicating differentially targeting JAK (zeige JAK3 Proteine)/STAT (zeige STAT1 Proteine) signaling pathways.

  4. study demonstrates that overexpression of Porcine deltacoronavirus (PDCoV) nsp5 (zeige SPECC1 Proteine) also antagonizes IFN signaling by cleaving STAT2, an essential component of transcription factor complex ISGF3 (zeige STAT1 Proteine), and that PDCoV infection reduces the levels of STAT2, which may affect the innate immune response

  5. PKV VP3 associated with STAT2 and IRF9 (zeige IRF9 Proteine), and interfered with the formation of the STAT2-IRF9 (zeige IRF9 Proteine) and STAT2-STAT2 complex.

  6. The authors have discovered a novel phosphorylation of STAT2 on T387 that negatively regulates signal from the type I interferon receptor (zeige IFNAR1 Proteine) to the genome by transcription factor ISGF3 (zeige STAT1 Proteine).

  7. STAT2 recruits USP18 (zeige USP18 Proteine) to the type I IFN receptor subunit IFNAR2 (zeige IFNAR2 Proteine) via its constitutive membrane-distal STAT2-binding site.

  8. These results establish that activation of STAT (zeige STAT1 Proteine) pathway is essential for anti-hepatitis c virus efficacy of IFN-alpha (zeige IFNA Proteine).

  9. These findings indicate that overexpression of IFITM1 (zeige IFITM1 Proteine) enhances the aggressive phenotype of triple-negative SUM149 IBC cells and that this effect is dependent on STAT2/BRG1 (zeige SMARCA4 Proteine) interaction.

  10. These results suggest that STAT6 (zeige STAT6 Proteine) plays an important role in regulating Sp1 (zeige PSG1 Proteine) and BCL6 (zeige BCL6 Proteine) through STAT2 to exert the anti-proliferative effects of type I IFN.

Pig (Porcine) Signal Transducer and Activator of Transcription 2, 113kDa (STAT2) Interaktionspartner

  1. While La Piedad Michoacan Mexico Virus V protein does not affect the protein levels of STAT1 (zeige STAT1 Proteine) or STAT2, it does prevent the interferon (zeige IFNA Proteine)-induced phosphorylation and nuclear translocation of STAT1 (zeige STAT1 Proteine) and STAT2 thereby inhibiting cellular responses to interferon alpha (zeige IFNA Proteine)/beta.

  2. Taken together, results of these experiments describe for the first time a novel mechanism by which foot-and-mouth disease virus evolves to inhibit IFN signaling via blocking STAT1 (zeige STAT1 Proteine)/STAT2 nuclear translocation.

  3. Nsp1beta inhibits interferon-activated (zeige MNDA Proteine) STAT1 (zeige STAT1 Proteine)/STAT2 signal transduction by inducing karyopherin-alpha1 degradation.

  4. the majority of the STAT1 (zeige STAT1 Proteine)/STAT2/IRF9 (zeige IRF9 Proteine) (IFN regulatory factor 9) heterotrimers remained in the cytoplasm of PRRSV-infected cells, which indicates that the nuclear translocation of the heterotrimers was blocked

Cow (Bovine) Signal Transducer and Activator of Transcription 2, 113kDa (STAT2) Interaktionspartner

  1. Prolonged treatment with IFN-alpha (12-48 h) resulted in increased expression of STAT1 (zeige STAT1 Proteine) and, to a lesser extent, STAT2.

STAT2 Protein Überblick

Protein Überblick

The protein encoded by this gene is a member of the STAT protein family. In response to cytokines and growth factors, STAT family members are phosphorylated by the receptor associated kinases, and then form homo- or heterodimers that translocate to the cell nucleus where they act as transcription activators. In response to interferon (IFN), this protein forms a complex with STAT1 and IFN regulatory factor family protein p48 (ISGF3G), in which this protein acts as a transactivator, but lacks the ability to bind DNA directly. Transcription adaptor P300/CBP (EP300/CREBBP) has been shown to interact specifically with this protein, which is thought to be involved in the process of blocking IFN-alpha response by adenovirus. Multiple transcript variants encoding different isoforms have been found for this gene.

Alternative names and synonyms associated with STAT2

  • signal transducer and activator of transcription 2 (stat2)
  • signal transducer and activator of transcription 2, 113kDa (STAT2)
  • signal transducer and activator of transcription (AGAP000099-PA) (STAT2)
  • signal transducer and activator of transcription 2 (Stat2)
  • signal transducer and activator of transcription 2 (LOC100344467)
  • signal transducer and activator of transcription 2-like (LOC100858732)
  • signal transducer and activator of transcription 2, 113kDa (Stat2)
  • 1600010G07Rik Protein
  • AW496480 Protein
  • ISGF-3 Protein
  • P113 Protein
  • stat2 Protein
  • STAT113 Protein
  • wu:fj84d07 Protein

Bezeichner auf Proteinebene für STAT2

fj84d07 , signal transducer and activator of transcription 2 , signal transducer and activator of transcription (AGAP000099-PA) , interferon alpha induced transcriptional activator

GENE ID SPEZIES
565200 Danio rerio
712694 Macaca mulatta
1272172 Anopheles gambiae str. PEST
100270812 Salmo salar
20847 Mus musculus
288774 Rattus norvegicus
100344467 Oryctolagus cuniculus
100858732 Gallus gallus
6773 Homo sapiens
481111 Canis lupus familiaris
100719719 Cavia porcellus
396923 Sus scrofa
451996 Pan troglodytes
511023 Bos taurus
101108211 Ovis aries
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