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TM, especially TME45, maintains vascular integrity, at least in part, via Src signaling.
We conclude that pp60(Src) can directly inhibit DDAH (zeige DDAH2 Proteine) II and this is involved in the increased ADMA levels that enhance eNOS (zeige NOS3 Proteine) uncoupling during the development of acute lung injury (ALI).
Ambra1 (zeige AMBRA1 Proteine) binds to both FAK (zeige PTK2 Proteine) and Src in cancer cells. When FAK (zeige PTK2 Proteine) is present, Ambra1 (zeige AMBRA1 Proteine) is recruited to focal adhesions, promoting FAK (zeige PTK2 Proteine)-regulated cancer cell direction-sensing and invasion. However, when Ambra1 (zeige AMBRA1 Proteine) cannot bind to FAK (zeige PTK2 Proteine), abnormally high levels of phospho-Src and phospho-FAK (zeige PTK2 Proteine) accumulate at focal adhesions, positively regulating adhesion and invasive migration.
Thus we propose that Cx43 (zeige GJA1 Proteine) might enhance the activation of Nrf2 (zeige NFE2L2 Proteine)/ARE pathway by means of inhibiting c-Src activity to hinder the nuclear export of Nrf2 (zeige NFE2L2 Proteine), and then reduce expression of FN, ICAM-1 (zeige ICAM1 Proteine) and TGF-b1, ultimately attenuating renal fibrosis in diabetes.
Osteoprotegerin (zeige TNFRSF11B Proteine) may induce podosome reassembly and peripheral adhesive structure detachment by modulating phosphorylation of Pyk2 (zeige PTK2B Proteine) and Src and their intracellular distribution in osteoclasts.
BMP2 (zeige BMP2 Proteine) also requires Src for filamentous actin polymerization in Tgfbr3 (zeige TGFBR3 Proteine)(-/-) epicardial cells.
v-Src prevents nuclear exclusion of YAP (zeige YAP1 Proteine) through a decrease in the phosphorylation of YAP (zeige YAP1 Proteine) at Ser127 in multinucleated cells.
These results revealed that vascular sprouting and permeability are both controlled through the VEGFR2-TSAd-c-Src signaling pathway in a subset of tissues, which may be useful in developing strategies to control tissue-specific pathological angiogenesis.
The TBK1 (zeige TBK1 Proteine) Y179A mutant failed to rescue type I IFN production by virally infected RAW264.7 macrophages deficient in TBK1 (zeige TBK1 Proteine).
identified both Syk (zeige SYK Proteine) and Src signaling pathways as ones that participate in Borrelia burgdorferi phagocytosis and the resulting cytokine activation.
Src64 controls actin dynamics to mediate proper ring canal formation during incomplete cytokinesis during germline cyst development in vivo
that Brat represses the translation of src64B, an upstream regulator of a conserved Rho-dependent pathway previously shown to promote axon retraction
Results show that Src42a and Src64b are required for the normal division capacity of Drosophila intestinal progenitor cells, and that these genes as well as Ack cause progenitor overproliferation in the intestine via core cell cycle activation.
a novel essential role for Src in intestinal stem/progenitor cell proliferation and tumourigenesis initiation in vivo.
Data show that the actin-Capping Protein (zeige TMOD4 Proteine) (CP) alphabeta heterodimer, which regulates actin (zeige ACTB Proteine) filament (F-actin (zeige ACTB Proteine)) polymerization, limits Src-induced apoptosis or tissue overgrowth by restricting JNK (zeige MAPK8 Proteine) activation.
Dumbfounded/Neph1 (zeige NEPH1 Proteine), a key diaphragm constituent, is a target of the Src kinase (zeige CSK Proteine) Src64B. Loss of Src64B activity leads to a reduction in the number of diaphragms, and this effect is in part mediated by loss of Dumbfounded/Neph1 (zeige NEPH1 Proteine) tyrosine phosphorylation.
Homodimerization of the Wnt receptor DERAILED recruits the Src family kinase SRC64B in the developing embryonic central nervous system.
E4orf4 has a role in inducing PP2A (zeige PPP2R2B Proteine)- and Src-dependent cell death while inhibiting classic apoptosis pathways in Drosophila melanogaster
Mutations in a Drosophila src gene, src64, that alter the three HRD amino acids, were identified.
Src64B overexpression induced the formation of specialized haemocytes (lamellocytes), but had no effect on circulating plasmatocyte concentration. Src64B overexpression induced F-actin (zeige ACTB Proteine) formation and Jun kinase (zeige MAPK9 Proteine) activation in plasmatocytes.
Findings indicate the importance of Src-Stat3 (zeige STAT3 Proteine) signaling cascade in gallic acid (GA)-mediated tumor-suppression activity and a therapeutic insight of GA for acquired resistance to EGF receptor (zeige EGFR Proteine) tyrosine kinase (zeige RET Proteine) inhibitors in lung cancer.
Memo (zeige MEMO1 Proteine) facilitates ER-alpha (zeige ESR1 Proteine) and c-Src interaction, ER-alpha (zeige ESR1 Proteine) Y537 phosphorylation, and has the ability to control ER-alpha (zeige ESR1 Proteine) extra-nuclear localization in breast cancer cells.
Data show that MLLT11/AF1q (zeige MLLT11 Proteine)-induced PDGFR (zeige PDGFRB Proteine) signaling enhanced STAT3 (zeige STAT3 Proteine) activity through Src kinase (zeige CSK Proteine) activation.
Loss of myristoylation abolished the tumorigenic potential of Src and its synergy with androgen receptor (zeige AR Proteine) in mediating tumor invasion.
N-WASP positively regulates demarcation membrane system development and proplatelet formation, and the Src family kinases in association with CDC42 regulate proplatelet formation through N-WASP
phosphorylation of mATG9 (zeige ATG9A Proteine) at Tyr8 by Src and at Ser14 by ULK1 (zeige ULK1 Proteine) functionally cooperate to promote interactions between mATG9 (zeige ATG9A Proteine) and the AP1 (zeige FOSB Proteine)/2 complex.
Data suggest that myristoylation of Src kinase (zeige CSK Proteine) is essential to facilitate Src-induced and high-fat diet-accelerated prostatic tumor progression; targeting Src kinase (zeige CSK Proteine) myristoylation, which is required for Src kinase (zeige CSK Proteine) association at cellular membrane, blocks dietary fat-accelerated tumorigenesis.
elevated levels of cellular Src in serum and phosphorylated Src in primary nasopharyngeal carcinoma tissue correlated with poor outcomes of these patients
Results indicate that src-family kinase (Src) is a upstream kinase of T-LAK cell-originated protein kinase (TOPK (zeige PBK Proteine)).
We suggest that the induction of SRC results in increased prostate cancer metastasis that is linked to the dysregulation of the AR signaling pathway through the inactivation of miR (zeige MLXIP Proteine)-203
RhoA (zeige RHOA Proteine) and membrane fluidity mediates the spatially polarized Src/FAK (zeige PTK2 Proteine) activation in response to shear stress.
AngII activates PKD via a mechanism involving Src family kinases and PKC, to underlie increased aldosterone production.
The Src gene possibly contributed to conducting association analysis and can be recognized as genetic marker in milk production traits and other performance for animal breeding and genetics.
src has a role in activation of 5'-AMP (zeige TMPRSS5 Proteine)-activated kinase during hypoxia-reoxygenation of bovine aortic endothelial cells
results indicate that integrin engagement disrupts VE-cadherin-containing adherens junctions via the activation of Src, but not Ras, possibly as a result of modulation of the actin network
These results suggest that TGF-beta1 (zeige TGFB1 Proteine)-induced monolayer permeability involves focal adhesion and cytoskeletal rearrangement through both FAK (zeige PTK2 Proteine)/Src-dependent and -independent pathways.
The findings are consistent with previous studies that indicate a link between Na,K-ATPase (zeige ATP1A1 Proteine) activity and SFK signaling.
Src kinase (zeige CSK Proteine) mediates hypoxia-induced caspase-1 (zeige CASP1 Proteine) activation in the cerebral cortex of newborn piglets
Expression of mutant alpha1 Na/K-ATPase (zeige ATP1A1 Proteine) defective in conformational transition attenuates Src-mediated signal transduction
20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism.
This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.
proto-oncogene tyrosine-protein kinase SRC
, proto-oncogene tyrosine-protein kinase src
, neuronal proto-oncogene tyrosine-protein kinase Src
, proto-oncogene c-Src
, Src proto oncogene sequence
, mRNA-like ncRNA in embryogenesis 5
, proto-oncogene tyrosine-protein kinase Src
, protooncogene SRC, Rous sarcoma
, tyrosine kinase pp60c-src
, tyrosine-protein kinase SRC-1
, Rous sarcoma oncogene
, tyrosine protein kinase c-src
, tyrosine protein kinase pp60-c-src
, v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
, src oncogene
, v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog
, non-tyrosine protein kinase