SRC Proteine (SRC)

Bezeichnung:
V-Src Sarcoma (Schmidt-Ruppin A-2) Viral Oncogene Homolog (Avian) Proteine (SRC)
Auf www.antikoerper-online.de finden Sie aktuell 22 V-Src Sarcoma (Schmidt-Ruppin A-2) Viral Oncogene Homolog (Avian) (SRC) Proteine von 10 unterschiedlichen Herstellern. Zusätzlich bieten wir Ihnen SRC Antikörper (451) und SRC Kits (20) und viele weitere Produktgruppen zu diesem Protein an. Insgesamt sind aktuell 519 SRC Produkte verfügbar.
Synonyme:
ASV, AW259666, c-Src, C-src1, CG7524, D-src, D-Src64B, Dmel\CG7524, DmHD-358, Dm SRC1, dsrc, Dsrc64, Dsrc64B, HD-358, MRE5, p60-Src, PP60C-SCR, pp60c-src, SDR, src, SRC1, src64, SRC 64B, src64b
alle Proteine anzeigen Gen GeneID UniProt
SRC 20779 P05480
SRC 6714 P12931
SRC 83805  

Weitere Synonyme anzeigen

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Am meisten referenzierte SRC Proteine

  1. Mouse (Murine) SRC Protein expressed in Baculovirus infected Insect Cells - ABIN2007642 : Czernilofsky, Levinson, Varmus, Bishop, Tischer, Goodman: Nucleotide sequence of an avian sarcoma virus oncogene (src) and proposed amino acid sequence for gene product. in Nature 1981 (PubMed)
    Zeige alle 3 Referenzen für 2007642

  2. Human SRC Protein expressed in Baculovirus infected Insect Cells - ABIN2003349 : Ma, Zhang: Lithium reduced N-methyl-D-aspartate receptor subunit 2A tyrosine phosphorylation and its interactions with Src and Fyn mediated by PSD-95 in rat hippocampus following cerebral ischemia. in Neuroscience letters 2003 (PubMed)
    Zeige alle 3 Referenzen für 2003349

Weitere Proteine zu SRC Interaktionspartnern

Mouse (Murine) V-Src Sarcoma (Schmidt-Ruppin A-2) Viral Oncogene Homolog (Avian) (SRC) Interaktionspartner

  1. PTPN2 (zeige PTPN2 Proteine) is a positive regulator of lipopolysaccharide-induced inflammatory response by enhancing the activity of Src through targeting the inhibitory phosphor-tyrosine527 of Src.

  2. demonstrated that both IL-10 (zeige IL10 Proteine) and TGF-beta (zeige TGFB1 Proteine) upregulated TIM-3 (zeige HAVCR2 Proteine) surface expression on dendritic cells via a common signaling pathway that involved sequential activation of c-Src and Bruton's tyrosine kinase (zeige BTK Proteine)

  3. Results suggest that interleukin-6 (IL-6 (zeige IL6 Proteine)) increases VEGF-C (zeige VEGFC Proteine) induction and lymphangiogenesis may involve, at least in part, Src-FAK (zeige PTK2 Proteine)-STAT3 (zeige STAT3 Proteine) cascade in lymphatic endothelial cells (LECs).

  4. Transcriptional signature induced by a metastasis-promoting c-Src mutant in a human breast cell line has been reported.

  5. Data show that the essential oil (EO) decreased focal adhesion and invadopodia formation which was accompanied by a drastic downregulation of focal adhesion kinase (FAK) and proto-oncogene protein Src.

  6. miR (zeige MLXIP Proteine)-222-3p serves as an inhibitor of osteoclastogenesis and c-Src mediates its inhibition of cathepsin K (zeige CTSK Proteine) and TRAP.

  7. results suggest that LPS (zeige TLR4 Proteine)-stimulated macrophage mediators attenuate both FAK (zeige PTK2 Proteine) and Src activations in osteoblast, suggesting a novel role for TNFalpha (zeige TNF Proteine) on osteoblast performance

  8. Src has a role in priming Pyk2 (zeige PTK2B Proteine) (but not FAK (zeige PTK2 Proteine)) phosphorylation and subsequent activation downstream of integrins

  9. Heritable pulmonary arterial hypertension (PAH) results from increased SRC activation, cellular contraction, and vascular resistance, but antagonism of HTR2B prevents SRC phosphorylation and development of PAH.

  10. Periodic axial motility of epithelial basal cell projections is controlled by c-Src.

Fruit Fly (Drosophila melanogaster) V-Src Sarcoma (Schmidt-Ruppin A-2) Viral Oncogene Homolog (Avian) (SRC) Interaktionspartner

  1. Src64 controls actin dynamics to mediate proper ring canal formation during incomplete cytokinesis during germline cyst development in vivo

  2. that Brat represses the translation of src64B, an upstream regulator of a conserved Rho-dependent pathway previously shown to promote axon retraction

  3. Results show that Src42a and Src64b are required for the normal division capacity of Drosophila intestinal progenitor cells, and that these genes as well as Ack cause progenitor overproliferation in the intestine via core cell cycle activation.

  4. a novel essential role for Src in intestinal stem/progenitor cell proliferation and tumourigenesis initiation in vivo.

  5. Data show that the actin-Capping Protein (zeige TMOD4 Proteine) (CP) alphabeta heterodimer, which regulates actin (zeige ACTB Proteine) filament (F-actin (zeige ACTB Proteine)) polymerization, limits Src-induced apoptosis or tissue overgrowth by restricting JNK (zeige MAPK8 Proteine) activation.

  6. Dumbfounded/Neph1 (zeige NEPH1 Proteine), a key diaphragm constituent, is a target of the Src kinase (zeige CSK Proteine) Src64B. Loss of Src64B activity leads to a reduction in the number of diaphragms, and this effect is in part mediated by loss of Dumbfounded/Neph1 (zeige NEPH1 Proteine) tyrosine phosphorylation.

  7. Homodimerization of the Wnt receptor DERAILED recruits the Src family kinase SRC64B in the developing embryonic central nervous system.

  8. E4orf4 has a role in inducing PP2A (zeige PPP2R2B Proteine)- and Src-dependent cell death while inhibiting classic apoptosis pathways in Drosophila melanogaster

  9. Mutations in a Drosophila src gene, src64, that alter the three HRD amino acids, were identified.

  10. Src64B overexpression induced the formation of specialized haemocytes (lamellocytes), but had no effect on circulating plasmatocyte concentration. Src64B overexpression induced F-actin (zeige ACTB Proteine) formation and Jun kinase (zeige MAPK9 Proteine) activation in plasmatocytes.

Human V-Src Sarcoma (Schmidt-Ruppin A-2) Viral Oncogene Homolog (Avian) (SRC) Interaktionspartner

  1. Results indicate Src homology 3 (SH3) domain-binding glutamic acid-rich-like protein (SH3BGRL) in driving tumor metastasis through c-Src activation, and suggests that hSH3BGRL mutation status could be relevant to cancer diagnosis and therapy.

  2. overexpression of syndecan-1 confers to B-LCs an increased capacity to migrate in response to Tat, owing to a switch from a CXCR4/G-protein/Rac to a syndecan-1/alphavbeta3/pp60src/pp125FAK signal transduction pathway that depends on the formation of a complex in which syndecan-1 interacts with Tat via its HS-chains, with alphavbeta3 via its core protein ectodomain and with pp60src via its intracellular tail

  3. the direct binding of ERalpha (zeige ESR1 Proteine)-36 to ERK2 (zeige MAPK1 Proteine) prevents its dephosphorylation by MKP3 (zeige DUSP6 Proteine) and enhances the downstream signaling. These findings improve our understanding of the regulation of non-genomic estrogen signaling and open new avenues for personalized therapeutic approaches targeting Src or MEK (zeige MAP2K1 Proteine) in ERalpha (zeige ESR1 Proteine)-36-positive patients.

  4. Csk (zeige CSK Proteine) induced phosphorylation of Src at tyrosine 530.

  5. regulation of Src activation and translocation

  6. SDCBP (zeige SDCBP Proteine) might be an important marker for identifying Triple negative breast cancer cases that are suitable for dasatinib therapy.

  7. Restoring miR (zeige MLXIP Proteine)-34a expression resulted in down-regulation of c-SRC and phosphorylated (Tyr416) c-SRC protein in K-562 cells, which consequently triggered suppression of the RAF (zeige RAF1 Proteine)/MEK (zeige MAP2K1 Proteine)/ERK (zeige EPHB2 Proteine) signaling pathway to decrease cell proliferation.

  8. This study suggests PRL-3 and SFKs are key mediators of the IL6 (zeige IL6 Proteine)-driven signaling events.

  9. the N-terminus of survivin (zeige BIRC5 Proteine) is a mitochondrial-targeting sequence that regulates Src.

  10. These results suggest that the activation of endogenous levels of SFK renders the endothelial barrier more susceptible to low, physiologic doses of TNF-alpha (zeige TNF Proteine) through activation of p38 (zeige CRK Proteine) which leads to a loss of endothelial tight junctions.

Cow (Bovine) V-Src Sarcoma (Schmidt-Ruppin A-2) Viral Oncogene Homolog (Avian) (SRC) Interaktionspartner

  1. RhoA (zeige RHOA Proteine) and membrane fluidity mediates the spatially polarized Src/FAK (zeige PTK2 Proteine) activation in response to shear stress.

  2. AngII activates PKD via a mechanism involving Src family kinases and PKC, to underlie increased aldosterone production.

  3. The Src gene possibly contributed to conducting association analysis and can be recognized as genetic marker in milk production traits and other performance for animal breeding and genetics.

  4. src has a role in activation of 5'-AMP (zeige TMPRSS5 Proteine)-activated kinase during hypoxia-reoxygenation of bovine aortic endothelial cells

  5. results indicate that integrin engagement disrupts VE-cadherin-containing adherens junctions via the activation of Src, but not Ras, possibly as a result of modulation of the actin network

  6. These results suggest that TGF-beta1 (zeige TGFB1 Proteine)-induced monolayer permeability involves focal adhesion and cytoskeletal rearrangement through both FAK (zeige PTK2 Proteine)/Src-dependent and -independent pathways.

Pig (Porcine) V-Src Sarcoma (Schmidt-Ruppin A-2) Viral Oncogene Homolog (Avian) (SRC) Interaktionspartner

  1. The findings are consistent with previous studies that indicate a link between Na,K-ATPase (zeige ATP1A1 Proteine) activity and SFK signaling.

  2. Src kinase (zeige CSK Proteine) mediates hypoxia-induced caspase-1 (zeige CASP1 Proteine) activation in the cerebral cortex of newborn piglets

  3. Expression of mutant alpha1 Na/K-ATPase (zeige ATP1A1 Proteine) defective in conformational transition attenuates Src-mediated signal transduction

  4. 20-HETE activates the Raf/MEK/ERK pathway in renal epithelial cells through an EGFR- and c-Src-dependent mechanism.

SRC Protein Überblick

Protein Überblick

This gene is highly similar to the v-src gene of Rous sarcoma virus. This proto-oncogene may play a role in the regulation of embryonic development and cell growth. The protein encoded by this gene is a tyrosine-protein kinase whose activity can be inhibited by phosphorylation by c-SRC kinase. Mutations in this gene could be involved in the malignant progression of colon cancer. Two transcript variants encoding the same protein have been found for this gene.

Alternative names and synonyms associated with SRC

  • v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (avian) (SRC)
  • proto-oncogene tyrosine-protein kinase src (AaeL_AAEL002471)
  • proto-oncogene tyrosine-protein kinase src (CpipJ_CPIJ010659)
  • Rous sarcoma oncogene (Src)
  • Src oncogene at 64B (Src64B)
  • v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (SRC)
  • v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog (Src)
  • v-src sarcoma viral oncogene (SRC)
  • ASV Protein
  • AW259666 Protein
  • c-Src Protein
  • C-src1 Protein
  • CG7524 Protein
  • D-src Protein
  • D-Src64B Protein
  • Dmel\CG7524 Protein
  • DmHD-358 Protein
  • Dm SRC1 Protein
  • dsrc Protein
  • Dsrc64 Protein
  • Dsrc64B Protein
  • HD-358 Protein
  • MRE5 Protein
  • p60-Src Protein
  • PP60C-SCR Protein
  • pp60c-src Protein
  • SDR Protein
  • src Protein
  • SRC1 Protein
  • src64 Protein
  • SRC 64B Protein
  • src64b Protein

Bezeichner auf Proteinebene für SRC

proto-oncogene tyrosine-protein kinase SRC , proto-oncogene tyrosine-protein kinase src , neuronal proto-oncogene tyrosine-protein kinase Src , p60-Src , proto-oncogene c-Src , CG7524-PB , CG7524-PC , CG7524-PD , CG7524-PE , CG7524-PF , CG7524-PG , CG7524-PH , CG7524-PI , CG7524-PJ , Src proto oncogene sequence , Src64B-PB , Src64B-PC , Src64B-PD , Src64B-PE , Src64B-PF , Src64B-PG , Src64B-PH , Src64B-PI , Src64B-PJ , mRNA-like ncRNA in embryogenesis 5 , proto-oncogene tyrosine-protein kinase Src , protooncogene SRC, Rous sarcoma , tyrosine kinase pp60c-src , tyrosine-protein kinase SRC-1 , Rous sarcoma oncogene , c-Src , pp60c-src , tyrosine protein kinase c-src , tyrosine protein kinase pp60-c-src , v-src sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog , src oncogene , v-src avian sarcoma (Schmidt-Ruppin A-2) viral oncogene homolog , non-tyrosine protein kinase

GENE ID SPEZIES
458229 Pan troglodytes
5574802 Aedes aegypti
6043642 Culex quinquefasciatus
20779 Mus musculus
48973 Drosophila melanogaster
6714 Homo sapiens
83805 Rattus norvegicus
485864 Canis lupus familiaris
535742 Bos taurus
100154503 Sus scrofa
396442 Gallus gallus
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