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Here the authors show that suppressor of cytokine signaling (SOCS (zeige CISH Proteine)) five has a pivotal role in restricting influenza A virus in the airway epithelium, through the regulation of epidermal growth factor receptor (EGFR (zeige EGFR Proteine)).
This study showed that SOCS5 expression was significantly down-regulated.
Opisthorchis felineus infection diminishes the risk of atopic bronchial asthma associated with the SOCS5 gene polymorphism.
different domains in SOCS5 contribute to two distinct mechanisms for regulation of cytokine and growth factor signaling with JAK1 (zeige JAK1 Proteine) and SHC-1 (zeige SHC1 Proteine)
The rs6737848 SOCS5 polymorphism was significantly associated with asthma in additive model and in dominant model
Exogenous miR (zeige MLXIP Proteine)-9 effectively reduced SOCS5 levels, leading to activated JAK (zeige JAK3 Proteine)-STAT (zeige STAT1 Proteine) pathway, which promoted endothelial cell migration and tumour angiogenesis
Identified is a conserved region of about 70 residues in the N-terminal domains of SOCS4 (zeige SOCS6 Proteine) and 5 that is predicted to be more ordered than the surrounding sequence.
The results may contribute to understanding SOCS5 and SOCS6 (zeige SOCS6 Proteine) expression regulation in various cancer tissues, and show that these two factors may be used for diagnosing cancer.
Up regulation of SOCS1 (zeige SOCS1 Proteine) and SOCS5 expression and down-regulation of SOCS3 (zeige SOCS3 Proteine) and CIS (zeige CISH Proteine) may correlate with the development of a Th1 (zeige TH1L Proteine) mediated immune response in Vogt-Koyanagi-Harada disease.
The reduction in EGFR (zeige EGFR Proteine) levels and EGF (zeige EGF Proteine)-induced signaling in SOCS5-expressing cells requires both the Src (zeige SRC Proteine) homology-2 and SOCS (zeige CISH Proteine) box domains of SOCS5.
this study shows that DRD3 (zeige DRD3 Proteine) signaling evokes Socs5 expression, a negative regulator of Th2 development, which indirectly favors acquisition of Th1 (zeige HAND1 Proteine) phenotype
have identified a phosphorylation site (Ser211) within the JIR of mSOCS5 and have investigated the role of phosphorylation in modulating JAK (zeige JAK3 Proteine) binding using site-directed mutagenesis.
Identified is a conserved region of about 70 residues in the N-terminal domains of Socs4 (zeige SOCS6 Proteine) and 5 that is predicted to be more ordered than the surrounding sequence.
The effect of Flt3 (zeige FLT3 Proteine)-L on Th17 cells and expression of suppressors of cytokine signaling (SOCS (zeige CISH Proteine)) proteins in the lungs of house dust mite (HDM (zeige HDAC3 Proteine))-sensitized and -challenged mice, was evaluated.
SOCS5 regulates Th1 (zeige HAND1 Proteine)/Th2 cell balance and suppresses IL-4 (zeige IL4 Proteine)
SOCS5-deficient CD4 (zeige CD4 Proteine) T cells showed no abnormalities in Th1 (zeige HAND1 Proteine)/Th2 differentiation and Socs5(-/-) mice showed normal resistance to infection with Leishmania major.
SOCS-5 associated with the EGF-R (zeige EGFR Proteine) complex in an EGF (zeige EGF Proteine)-independent manner
Adoptive transfer of SOCS5Tg-CD4 (zeige CD4 Proteine)+ T cells into T- and B cell-deficient RAG-2 (zeige RAG2 Proteine)(-/-) mice resulted in augmented leukocyte infiltration and increased peritoneal levels of IL-12 (zeige IL12A Proteine), IFN-gamma (zeige IFNG Proteine), and TNF-alpha (zeige TNF Proteine) after cecal ligation and puncture
The protein encoded by this gene contains a SH2 domain and a SOCS BOX domain. The protein thus belongs to the suppressor of cytokine signaling (SOCS) family, also known as STAT-induced STAT inhibitor (SSI) protein family. SOCS family members are known to be cytokine-inducible negative regulators of cytokine signaling. The specific function of this protein has not yet been determined. Two alternatively spliced transcript variants encoding an identical protein have been reported.
suppressor of cytokine signaling 5
, suppressor of cytokine signaling 5-like
, cytokine-inducible SH2 protein 6
, cytokine-inducible SH2-containing protein 5
, cytokine inducible SH2-containing protein 5