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The upregulation of SOCS-1 (zeige SOCS1 ELISA Kits) and SOCS-2 by cortisol may be playing a key role in suppressing cytokine signaling and the associated inflammatory response.
Long-term palmitate treatment up-regulates SOCS2 and reduces PI3K (zeige PIK3CA ELISA Kits) activity, thereby impairing glucose stimulated insulin (zeige INS ELISA Kits) secretion.
Targeting of SOCS2 by miR (zeige MLXIP ELISA Kits)-194 resulted in derepression of the oncogenic kinases FLT3 (zeige FLT3 ELISA Kits) and JAK2 (zeige JAK2 ELISA Kits), leading to enhanced ERK (zeige EPHB2 ELISA Kits) and STAT3 (zeige STAT3 ELISA Kits) signaling.
Single-cell RNA sequencing reveals enrichment of homeostatic modules in monocytes and dendritic cells from human metastatic melanoma. Suppressor-of-cytokine-2 (SOCS2) protein, a conserved program transcript, is expressed by mononuclear phagocytes infiltrating primary melanoma and is induced by IFNgamma.
this study shows that IL-7 (zeige IL7 ELISA Kits) induces the expression of SOCS2 through the JAK (zeige JAK3 ELISA Kits)/STAT-5 (zeige STAT5A ELISA Kits) pathway and that SOCS2 interacts with CD127 (zeige IL7R ELISA Kits) in early endosomes and direct the receptor complex to the proteasome for degradation
Overexpression of SOCS2 inverted these phenotypes generated by hsv2-miR (zeige MLXIP ELISA Kits)-H9-5p, indicating the potential roles of SOCS2 in Hsv2-miR (zeige MLXIP ELISA Kits)-H9-5p-driven metastasis in lung cancers. The results highlighted that Hsv2-miR (zeige MLXIP ELISA Kits)-H9-5p regulated and contributed to bone metastasis of lung cancers. We proposed that Hsv2-miR (zeige MLXIP ELISA Kits)-H9-5p could be used as a potential target in lung cancer therapy
Overexpression of SOCS-2 is associated with hepatocellular carcinoma.
focus on SOCS2 and review its biological function as well as its implication in pathological processes
SOCS2 may improve outcome of TBI in mice by regulating aspects of the neuroinflammatory response
This study showed that there was significantly increased levels of SOCS-2 mRNA in elderly and Alzheimer's disease brains.
crystals of SOCS2 in complex with its adaptor proteins, Elongin C (zeige TCEB1 ELISA Kits) and Elongin B (zeige TCEB2 ELISA Kits), underwent a change in crystallographic parameters when treated with dimethyl sulfoxide during soaking experiments.
Our data show that absence of SOCS2 turns cardiomyocytes unresponsive to LIF (zeige LIF ELISA Kits)-induced [Ca(2 (zeige CA2 ELISA Kits)+)] raise, indicating that endogenous levels of SOCS2 are crucial for full activation of LIF (zeige LIF ELISA Kits) signaling in the heart.
Knockdown of SOCS2 makes mice less sensitive to multiple low dose streptozotocin.
Study provides an insight into the role of SOCS2 in modulating the immune response to Bovine herpesvirus 5 [BoHV-5]infection.
Data (including data from studies in knockout mice) suggest Socs2 regulates liver regeneration rate after partial hepatectomy, Ghr (growth hormone receptor (zeige GHR ELISA Kits)) level via ubiquitination/proteolysis, and serum Igf1 (insulin-like growth factor-1 (zeige IGF1 ELISA Kits)) level.
GH appears to act directly on the metatarsals of Socs2(-/-) mice, promoting growth via a mechanism that is independent of IGF-1 (zeige IGF1 ELISA Kits).
comparison of murine wt and Socs2(-/-) HSC (zeige FUT1 ELISA Kits) gene expression in response to 5-FU revealed a significant overlap with the molecular programs that correlate with SOCS2 expression in leukemias, particularly with the oncogenic pathways
Studies indicate the critical role of suppressor of cytokine signaling 2 (SOCS2) in ontrolling the local growth hormone (GH (zeige GH1 ELISA Kits)) anabolic bone effects.
Taken together, our observations indicated that SOCS2 could suppress myotube formation, act as an anti-regulator of mitochondria biogenesis via inhibiting p38 MAPK (zeige MAPK14 ELISA Kits) signal pathway.
SOCS2 immunoprecipitates with TrkA (zeige NTRK1 ELISA Kits) and a juxtamembrane motif of TrkA (zeige NTRK1 ELISA Kits) is required for this interaction. Over-expression of SOCS2 in PC12 Tet-On cells increased total and surface TrkA (zeige NTRK1 ELISA Kits) expression. SOCS2 regulates neurite outgrowth.
Results show that CISH (zeige CISH ELISA Kits) has no non-redundant functions in beta cell proliferation or glucose homeostasis during pregnancy in mice. Socs2 might compensate for the loss of Cish (zeige CISH ELISA Kits) during pregnancy.
hepatic growth hormone receptor (zeige GHR ELISA Kits) and suppressor of cytokine signaling (SOCS (zeige CISH ELISA Kits))2 messenger RNA expression appeared to be promptly and sensitively regulated by increased estradiol levels before ovulation of dairy heifers
relative amount of suppressors of cytokine signaling-2 (SOCS-2)messenger RNA increased after parturition
This gene encodes a member of the suppressor of cytokine signaling (SOCS) family. SOCS family members are cytokine-inducible negative regulators of cytokine receptor signaling via the Janus kinase/signal transducer and activation of transcription pathway (the JAK/STAT pathway). SOCS family proteins interact with major molecules of signaling complexes to block further signal transduction, in part, by proteasomal depletion of receptors or signal-transducing proteins via ubiquitination. The expression of this gene can be induced by a subset of cytokines, including erythropoietin, GM-CSF, IL10, interferon (IFN)-gamma and by cytokine receptors such as growth horomone receptor. The protein encoded by this gene interacts with the cytoplasmic domain of insulin-like growth factor-1 receptor (IGF1R) and is thought to be involved in the regulation of IGF1R mediated cell signaling. This gene has pseudogenes on chromosomes 20 and 22. Alternative splicing results in multiple transcript variants.
suppressor of cytokine signaling-2
, suppressor of cytokine signaling 2
, suppressor of cytokine signaling 2 variant 1
, STAT induced STAT inhibitor-2
, STAT-induced STAT inhibitor 2
, STAT-induced STAT inhibitor-2
, cytokine-inducible SH2 protein 2
, cytokine inducible SH2-containing protein 2
, suppressor of cytokine signalling 2