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5-HT(2) receptors are coupled to phospholipase C (zeige PLC Proteine) in bovine ciliary epithelium.
Our results indicate that prolonged Htr2b activation in murine beta-cells decreases glucose-stimulated insulin secretion and mitochondrial activity by mechanisms likely dependent on enhanced PGC1a/PPARygexpression.
heterodimerization with 5-HT2C receptors does not alter 5-HT2C Galphaq-dependent inositol phosphate signaling, 5-HT2A or 5-HT2B receptor-mediated signaling was totally blunted. This feature can be explained by a dominance of 5-HT2C on 5-HT2A and 5-HT2B receptor binding; in 5-HT2C-containing heterodimers, ligands bind and activate the 5-HT2C protomer exclusively.
Activation of 5-HT2B receptors stimulates GSIS in beta cells by triggering downstream changes in cellular Ca(2 (zeige CA2 Proteine)+) flux that enhance mitochondrial metabolism.
Heritable pulmonary arterial hypertension (PAH) results from increased SRC activation, cellular contraction, and vascular resistance, but antagonism of HTR2B prevents SRC phosphorylation and development of PAH.
Results support that the abnormal organization of retinal projections in Htr2B-/- animals is due to the lack of 5-HT (zeige DDC Proteine) activation of 5-HT2B receptors in postnatal microglial cells
5-HT2B stimulation has no effectin neurite outgrowth.
the serotonin transporter (zeige SLC6A4 Proteine) has a role in regulating clearance of apoptotic cells through neuroendocrine signaling
Serotonin 2B receptor (5-HT2B R) signals through prostacyclin and PPAR (zeige PPARA Proteine)-ss/delta in osteoblasts.
the results suggested that RKT improves the decrease in food intake after novelty stress probably via 5-HT(2B) receptor antagonism of isoliquiritigenin contained in RKT.
Augmented contractile properties of arteries in a model of type 2 diabetes mellitus are not due to changes in 5HT (zeige DDC Proteine)(2A)/5HT (zeige DDC Proteine)(2B) receptors.
MFSD2B, CCL20 (zeige CCL20 Proteine) and STAT1 (zeige STAT1 Proteine), or STARD7 (zeige STARD7 Proteine) and ZNF512 genes may be risk or protect factors in prognosis of ADC (zeige ADC Proteine); HTR2B, DPP4 (zeige DPP4 Proteine), and TGFBRAP1 (zeige TGFBRAP1 Proteine) genes may be risk factors in prognosis of SQC (zeige QPCT Proteine).
The HTR2B Q20* allele and testosterone predicted lower BMI independently, but an interaction between HTR2B Q20* and testosterone lead to increased insulin (zeige INS Proteine) sensitivity among HTR2B Q20* carriers with low testosterone levels.
Study describes the crystal structure of Lysergic acid diethylamide (LSD (zeige DNASE1L3 Proteine)) in complex with the human serotonin receptor (zeige HTR1B Proteine) 5-HT2B. The complex reveals conformational rearrangements to accommodate LSD (zeige DNASE1L3 Proteine), providing a structural explanation for the conformational selectivity of LSD's key diethylamide moiety.
The 5-HT2B receptor may contribute to the regulation of human glucagon (zeige GCG Proteine) and glucose homeostasis and the interplay between glucagon (zeige GCG Proteine) and insulin (zeige INS Proteine) secretion.
Authors hypothesize that HTR2B expression in the infarcted territory may render degenerating neurons susceptible to attack by activated microglia and thus aggravate the consequences of stroke.
the 5-HT2B receptor limits degeneration of spinal cord mononuclear phagocytes, most likely microglia, and slows disease progression in amyotrophic lateral sclerosis
Studies have found that the HTR2B Q20* connected with impulsive behavior and cognitive impulsivity.
Data indicate that hydrogen bonding interactions with Ser3.36 and Thr3.37 were important for isoflurane binding with the 5HT2B receptor.
distribution of serotonin 2B receptor is species different in the pig small intestine and the intensity of serotonin 2B receptor becomes stronger as the small intestine matures
This gene encodes one of the several different receptors for 5-hydroxytryptamine (serotonin) that belongs to the G-protein coupled receptor 1 family. Serotonin is a biogenic hormone that functions as a neurotransmitter, a hormone, and a mitogen. Serotonin receptors mediate many of the central and peripheral physiologic functions of serotonin, including regulation of cardiovascular functions and impulsive behavior. Population and family-based analyses of a minor allele (glutamine-to-stop substitution, designated Q20*) which blocks expression of this protein, and knockout studies in mice, suggest a role for this gene in impulsivity. However, other factors, such as elevated testosterone levels, may also be involved.
5-hydroxytryptamine (serotonin) receptor 2B
, 5-hydroxytryptamin receptor
, 5-hydroxytryptamine receptor 2B
, 5HT2B receptor
, serotonin receptor 2B
, 5-hydroxytryptamine receptor 2B-like
, NP75 protein
, 5-HT2B serotonin receptor
, 5-HT 2B receptor
, 5-hydroxytryptamine 2B receptor
, 5-hydroxytryptamine receptor 2B variant b
, stomach fundus serotonin receptor
, serotonin 2B receptor