anti-Frosch PTPN11 Antikörper für Immunoprecipitation

Recommended PTPN11 Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11) Antikörper
  • BPTP3
  • CFC
  • NS1
  • PTP-1D
  • PTP2C
  • SH-PTP2
  • SH-PTP3
  • SHP2
  • 2700084A17Rik
  • AW536184
  • PTP1D
  • SAP-2
  • SHP-2
  • Shp2
  • Syp
  • SYP
  • protein tyrosine phosphatase, non-receptor type 11
  • PTPN11
  • Ptpn11
Epitop
AA 1-177
54
50
30
21
19
17
15
15
15
10
5
3
3
3
3
3
3
2
2
2
2
2
2
2
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
1
Reaktivität
Huhn, Hund, Frosch, Human, Maus, Ratte (Rattus)
373
230
201
14
12
12
11
11
10
9
7
4
3
3
2
2
1
1
Wirt
Maus
304
57
19
2
1
Klonalität
Monoklonal
Konjugat
Dieser PTPN11 Antikörper ist unkonjugiert
10
9
9
7
6
5
4
4
4
4
4
4
4
4
4
4
4
2
2
1
1
1
1
1
1
1
1
1
1
1
Applikation
Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
291
127
106
85
52
48
36
22
17
6
4
3
3
2
1
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Bilder

Produktnummer ABIN968068
Preis und Verfügbarkeit auf Anfrage.
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN968069 IF IP IHC WB Mouse IgG1 AA 1-177 Anmelden zum Anzeigen 79-PTP1D-SHP2 5

General

Antigen Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11) Antikörper
Epitop AA 1-177
(54), (50), (30), (21), (19), (17), (15), (15), (15), (10), (5), (3), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Reaktivität Huhn, Hund, Frosch, Human, Maus, Ratte (Rattus)
(373), (230), (201), (14), (12), (12), (11), (11), (10), (9), (7), (4), (3), (3), (2), (2), (1), (1)
Wirt Maus
(304), (57), (19), (2), (1)
Klonalität (Klon)
Monoklonal   ( )
Konjugat Dieser PTPN11 Antikörper ist unkonjugiert
(10), (9), (9), (7), (6), (5), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (4), (2), (2), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1), (1)
Applikation Immunofluorescence (IF), Immunoprecipitation (IP), Immunohistochemistry (IHC), Western Blotting (WB)
(291), (127), (106), (85), (52), (48), (36), (22), (17), (6), (4), (3), (3), (2), (1), (1), (1)
Pubmed 5 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-PTPN11 Antikörper

Target Details PTPN11 Anwendungsinformationen Handhabung Referenzen für anti-PTPN11 Antikörper (ABIN968068) Bilder
Kreuzreaktivität Maus, Ratte (Rattus), Hund, Huhn, Frosch
Produktmerkmale 1. Since applications vary, each investigator should titrate the reagent to obtain optimal results.
2. Please refer to us for technical protocols.
3. Caution: Sodium azide yields highly toxic hydrazoic acid under acidic conditions. Dilute azide compounds in running water before discarding to avoid accumulation of potentially explosive deposits in plumbing.
4. Source of all serum proteins is from USDA inspected abattoirs located in the United States.
Reinigung The monoclonal antibody was purified from tissue culture supernatant or ascites by affinity chromatography.
Immunogen Human PTP1D (SHP2) aa. 1-177
Klon 79-PTP1D-SHP2
Isotyp IgG1

Target Details PTPN11

Produktdetails anti-PTPN11 Antikörper Anwendungsinformationen Handhabung Referenzen für anti-PTPN11 Antikörper (ABIN968068) Bilder zurück nach oben
Antigen
Andere Bezeichnung PTP1D (PTPN11 Antibody Abstract)
Hintergrund SHP2 (also known as PTP1D, Syp, SHPTP2 and PTP2C) is a member of the cytosolic class of protein-tyrosine phosphatases (PTPs). SHP2 has been reported to contain two SH2 domains where both SH2 domains are N-terminal to the PTP catalytic domain. The expression of SHP2 has been reported to be highest in brain, heart, and kidney. The PTPs are thought to function with other protein-tyrosine kinases to maintain intracellular protein phosphotyrosine homeostasis and cell cycle progression. The presence of SH2 domains in SHP2 (PTP1D) has prompted speculation that binding to specific phosphorylated tyrosine residues is key to its function. SHP2 (PTP1D) is tyrosine- phosphorylated and activated in response to stimulation with EGF or PDGF.
Synonyms: PTP1D, Syp, SHPTP2 and PTP2C
Molekulargewicht 65-72 kDa
Pathways JAK-STAT Signalweg, RTK Signalweg, T-Zell Rezeptor Signalweg, Interferon-gamma Pathway, Fc-epsilon Rezeptor Signalübertragung, EGFR Signaling Pathway, Neurotrophin Signalübertragung, Negative Regulation of Hormone Secretion, Carbohydrate Homeostasis, Toll-Like Receptors Cascades, CXCR4-mediated Signaling Events, Signaling Events mediated by VEGFR1 and VEGFR2, Signaling of Hepatocyte Growth Factor Receptor, VEGFR1 Specific Signals

Anwendungsinformationen

Produktdetails anti-PTPN11 Antikörper Target Details PTPN11 Handhabung Referenzen für anti-PTPN11 Antikörper (ABIN968068) Bilder zurück nach oben
Kommentare

Related Products: ABIN968537, ABIN967389

Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-PTPN11 Antikörper Target Details PTPN11 Anwendungsinformationen Referenzen für anti-PTPN11 Antikörper (ABIN968068) Bilder zurück nach oben
Format Liquid
Konzentration 250 μg/mL
Buffer Aqueous buffered solution containing BSA, glycerol, and ≤0.09 % sodium azide.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store undiluted at -20° C.

Referenzen für anti-PTPN11 Antikörper (ABIN968068)

Produktdetails anti-PTPN11 Antikörper Target Details PTPN11 Anwendungsinformationen Handhabung Bilder zurück nach oben
Produkt verwendet in:

Duchene, Schanstra, Pecher, Pizard, Susini, Esteve, Bascands, Girolami: "A novel protein-protein interaction between a G protein-coupled receptor and the phosphatase SHP-2 is involved in bradykinin-induced inhibition of cell proliferation." in: The Journal of biological chemistry, Vol. 277, Issue 43, pp. 40375-83, 2002

Kabat, Borrego, Brooks, Coligan: "Role that each NKG2A immunoreceptor tyrosine-based inhibitory motif plays in mediating the human CD94/NKG2A inhibitory signal." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 169, Issue 4, pp. 1948-58, 2002

Kontaridis, Liu, Zhang, Bennett: "Role of SHP-2 in fibroblast growth factor receptor-mediated suppression of myogenesis in C2C12 myoblasts." in: Molecular and cellular biology, Vol. 22, Issue 11, pp. 3875-91, 2002

Freeman, Plutzky, Neel: "Identification of a human src homology 2-containing protein-tyrosine-phosphatase: a putative homolog of Drosophila corkscrew." in: Proceedings of the National Academy of Sciences of the United States of America, Vol. 89, Issue 23, pp. 11239-43, 1993

Vogel, Lammers, Huang, Ullrich: "Activation of a phosphotyrosine phosphatase by tyrosine phosphorylation." in: Science (New York, N.Y.), Vol. 259, Issue 5101, pp. 1611-4, 1993

Bilder

Produktdetails anti-PTPN11 Antikörper Target Details PTPN11 Anwendungsinformationen Handhabung Referenzen für anti-PTPN11 Antikörper (ABIN968068) zurück nach oben
Bilder des Herstellers
Western Blotting (WB) image for anti-Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11) (AA 1-177) antibody (ABIN968068) Western blot analysis of SHP2 (PTP1D) on a Jurkat cell lysate (Human T-cell leukemia,...
Immunofluorescence (IF) image for anti-Protein tyrosine Phosphatase, Non-Receptor Type 11 (PTPN11) (AA 1-177) antibody (ABIN968068) Immunofluorescence staining of A431 cells (Human epithelial carcinoma, ATCC CRL-1555).