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Rat (Rattus) JAK2 ELISA Kit für Sandwich ELISA - ABIN435372
Li, Ma, Jiang, Bai, Yan, Liu, Pan, Liu, Chen: Xiaoyaosan exerts anxiolytic-like effects by down-regulating the TNF-α/JAK2-STAT3 pathway in the rat hippocampus. in Scientific reports 2017
Of two Jak2 paralogues present in zebrafish, Jak2a but not Jak2b is involved in the intracellular transmission of the Ifn-gamma (zeige IFNG ELISA Kits) signal.
JAK2(V617F) mutation is associated with myelofibrosis.
the frequencies of mutations from JAK2 wild-type to JAK2V617F and vice versa increased following erythroid differentiation
we report that the recipient and the donor JAK2 46/1 haplotypes are significantly associated with aGvHD grades II-IV in AML (zeige RUNX1 ELISA Kits) patients undergoing allo-HSCT.
our studies suggest that the JAK2(V617F)-bearing ECs form an important component of the myeloproliferative neoplasms vascular niche and contribute to mutant stem/progenitor cell expansion, likely through a critical role of the TPO (zeige THPO ELISA Kits)/MPL (zeige MPL ELISA Kits) signaling axis.
Data show that co-treated with vincristine and XL019, a inhibitor of JAK2 and P-glycoprotein (P-gp), up-regulated expression of p21 and phosphorylated H2A histone family, member X (pH2AX).
dehydrocostus lactone significantly inhibits the phosphorylation expression of Bcr/Abl (zeige ABL1 ELISA Kits), STAT5 (zeige STAT5A ELISA Kits), JAK2, and STAT3 (zeige STAT3 ELISA Kits) and downstream molecules including p-CrkL (zeige CRKL ELISA Kits), Mcl-1 (zeige MCL1 ELISA Kits), Bcl-XL (zeige BCL2L1 ELISA Kits), and Bcl-2 (zeige BCL2 ELISA Kits) proteins in K562 cells.
JAK2V617F mutation influences myeloproliferative neoplasm-associated inflammation with a strong correlation between allele burden and PTX3 (zeige PITX3 ELISA Kits) levels.
TGR5 (zeige GPBAR1 ELISA Kits) exhibits significantly higher expression in NSCLC tumor samples and facilitates the growth and metastasis of NSCLC by activating the JAK2/STAT3 (zeige STAT3 ELISA Kits) signaling pathway.
JAK2V617F mutations were found in 59 patients in the olycythemia vera (zeige IGF2BP3 ELISA Kits) group
Essential Thrombocythemia and Primary Myelofibrosis patients with JAK2 V617F mutations are at high risk for Thrombotic Events.
After Dox treatment, the protein expression of p-Jak2 and p-Stat3 (zeige STAT3 ELISA Kits) levels was significantly increased in MT(+/+) cardiomyocytes, suggesting that the JAK2/STAT3 (zeige STAT3 ELISA Kits) pathway was partially involved in MT protection against Dox-induced cardiotoxicity
CIS (zeige CISH ELISA Kits) interacted with phosphorylated EpoR (zeige EPOR ELISA Kits) at Y401, which was critical for the activation of STAT5 (zeige STAT5A ELISA Kits) and ERK (zeige EPHB2 ELISA Kits).
Cell volume homeostasis requiring Na+/H+ exchange signaled by JAK2 first becomes prominent during mouse embryonic development at the late one-cell stage.
a novel signaling axis that regulates JAK2 in normal and malignant HSPCs and suggest new therapeutic strategies for treating CBL (zeige CBL ELISA Kits)(mut (zeige MUT ELISA Kits)) myeloid malignancies.
In summary, JAK2 functions in a homeostatic capacity in podocytes by facilitating autophagy. It does this by regulating the expression of the transcription factor TFEB that is necessary for normal autophagic-lysosomal function
these findings demonstrate that expression of Hmga2 cooperates with Jak2(V617F) in the pathogenesis of Mmyelofibrosis.
Study shows that Jak2 with V617F mutation induces murine model for myeloproliferative neoplasm.
results suggest that loss of Ezh2 (zeige EZH2 ELISA Kits) cooperates with Jak2V617F in the development of myelofibrosis in Jak2V617F
JAK2-V617F-expressing mice treated with an Ezh2 (zeige EZH2 ELISA Kits) inhibitor showed higher platelet counts than vehicle controls. Our data support the proposed tumor suppressor function of EZH2 (zeige EZH2 ELISA Kits)
findings demonstrate that clinically relevant doses of the JAK1 (zeige JAK1 ELISA Kits)/2 inhibitor ruxolitinib suppresses the harmful consequences of macrophage overactivation characterizing Hemophagocytic lymphohistiocytosis in 2 murine models.
nitration of JAK2 may act as an inhibitory counterpart to phosphorylation activation, reflecting a very localized break on the progression of GH signal transduction processes spanning JAK (zeige JAK3 ELISA Kits)-STAT (zeige STAT1 ELISA Kits)-AKT (zeige AKT1 ELISA Kits) interactions
Janus kinase 2 (JAK2) gene polymorphism is a potential marker for milk production traits in cattle
Results indicate that SNPs in STAT5A (zeige STAT5A ELISA Kits) and JAK2 genes were associated with somatic cell count and score in milk and cytokines but none of the SNP was associated with milk production traits suggesting an important role in immunity.
Methionine promoted casein synthesis, and this may be mediated by enhanced intracellular substrate availability and by activating JAK2-STAT5 (zeige STAT5A ELISA Kits) and mTOR (zeige FRAP1 ELISA Kits) signaling pathways.
SNPs in JAK2 and STAT5B (zeige STAT5B ELISA Kits) are associated with mastitis susceptibility in Chinese Holstein cattle
Localized changes in the state of nitration of regulatory phosphorylation domains of JAK2 in caveoLAE during inflammation suggest a unique mechanism through which discrete signal transduction switching might occur in the liver
This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis.
, PTK JAK2b
, protein tyrosine kinase JAK2b
, tyrosine-protein kinase JAK2
, Janus kinase 2 (a protein tyrosine kinase)
, tyrosine kinase