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anti-Human JAK2 Antikörper:
anti-Mouse (Murine) JAK2 Antikörper:
anti-Rat (Rattus) JAK2 Antikörper:
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Human JAK2 Primary Antibody für IHC - ABIN966430
Argetsinger, Kouadio, Steen, Stensballe, Jensen, Carter-Su: Autophosphorylation of JAK2 on tyrosines 221 and 570 regulates its activity. in Molecular and cellular biology 2004
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Human Monoclonal JAK2 Primary Antibody für ELISA, WB - ABIN966429
Mol, de Rijke, Demacker, Stalenhoef: Plasma levels of lipid and cholesterol oxidation products and cytokines in diabetes mellitus and cigarette smoking: effects of vitamin E treatment. in Atherosclerosis 1997
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Human JAK2 Primary Antibody für IHC - ABIN966431
Feener, Rosario, Dunn, Stancheva, Myers: Tyrosine phosphorylation of Jak2 in the JH2 domain inhibits cytokine signaling. in Molecular and cellular biology 2004
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Human Polyclonal JAK2 Primary Antibody für FACS, IF - ABIN387982
Joos, Granzow, Holtgreve-Grez, Siebert, Harder, Martín-Subero, Wolf, Adamowicz, Barth, Lichter, Jauch: Hodgkin's lymphoma cell lines are characterized by frequent aberrations on chromosomes 2p and 9p including REL and JAK2. in International journal of cancer. Journal international du cancer 2002
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Human Monoclonal JAK2 Primary Antibody für ELISA, WB - ABIN969223
Pezet, Buteau, Kelly, Edery: The last proline of Box 1 is essential for association with JAK2 and functional activation of the prolactin receptor. in Molecular and cellular endocrinology 1997
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Human Polyclonal JAK2 Primary Antibody für IF (p), IHC (p) - ABIN740955
Iriyama, Hatta, Takei: Direct effect of dasatinib on signal transduction pathways associated with a rapid mobilization of cytotoxic lymphocytes. in Cancer medicine 2016
Of two Jak2 paralogues present in zebrafish, Jak2a but not Jak2b is involved in the intracellular transmission of the Ifn-gamma (zeige IFNG Antikörper) signal.
JAK2V617F mutation influences myeloproliferative neoplasm-associated inflammation with a strong correlation between allele burden and PTX3 (zeige PITX3 Antikörper) levels.
TGR5 (zeige GPBAR1 Antikörper) exhibits significantly higher expression in NSCLC tumor samples and facilitates the growth and metastasis of NSCLC by activating the JAK2/STAT3 (zeige STAT3 Antikörper) signaling pathway.
JAK2V617F mutations were found in 59 patients in the olycythemia vera (zeige IGF2BP3 Antikörper) group
Essential Thrombocythemia and Primary Myelofibrosis patients with JAK2 V617F mutations are at high risk for Thrombotic Events.
CIS (zeige CISH Antikörper) interacted with phosphorylated EpoR (zeige EPOR Antikörper) at Y401, which was critical for the activation of STAT5 (zeige STAT5A Antikörper) and ERK (zeige EPHB2 Antikörper).
ANGPTL1 (zeige ANGPTL1 Antikörper) inhibited angiogenesis by interacting with integrin alpha1beta1 receptor to suppress the downstreamJAK2-STAT3 (zeige STAT3 Antikörper) signaling pathway.
Therefore, JAK2V617F influences target binding in both pSTAT3 and EZH2 (zeige EZH2 Antikörper). Without mutations in epigenetic regulators, JAK2V617F can induce downstream epigenomic modifications. Thus, epigenetic changes in JAK2 downstream targets might be trackable in vivo.
Subjects with JAK2V617F mutation and an allele burden>/=50% had an age-independent higher incidence of elevated hs-CRP (zeige CRP Antikörper) level (OR=1.97; 95% CI,1.21-3.22; P=0.006) compared with a combined cohort of subjects with JAK2V617F <50% allele burden
High JAK2 expression is associated with neuroblastoma (zeige ARHGEF16 Antikörper).
Study provides evidence that JAK1 (zeige JAK1 Antikörper)/2 loss-of-function mutations are a genetic mechanism of lack of reactive PD-L1 (zeige CD274 Antikörper) expression and response to interferon gamma (zeige IFNG Antikörper), leading to primary resistance to PD-1 (zeige PDCD1 Antikörper) blockade therapy.
Cell volume homeostasis requiring Na+/H+ exchange signaled by JAK2 first becomes prominent during mouse embryonic development at the late one-cell stage.
a novel signaling axis that regulates JAK2 in normal and malignant HSPCs and suggest new therapeutic strategies for treating CBL (zeige CBL Antikörper)(mut (zeige MUT Antikörper)) myeloid malignancies.
In summary, JAK2 functions in a homeostatic capacity in podocytes by facilitating autophagy. It does this by regulating the expression of the transcription factor TFEB (zeige TFEB Antikörper) that is necessary for normal autophagic-lysosomal function
these findings demonstrate that expression of Hmga2 cooperates with Jak2(V617F) in the pathogenesis of Mmyelofibrosis.
Study shows that Jak2 with V617F mutation induces murine model for myeloproliferative neoplasm.
results suggest that loss of Ezh2 (zeige EZH2 Antikörper) cooperates with Jak2V617F in the development of myelofibrosis in Jak2V617F
JAK2-V617F-expressing mice treated with an Ezh2 (zeige EZH2 Antikörper) inhibitor showed higher platelet counts than vehicle controls. Our data support the proposed tumor suppressor function of EZH2 (zeige EZH2 Antikörper)
findings demonstrate that clinically relevant doses of the JAK1 (zeige JAK1 Antikörper)/2 inhibitor ruxolitinib suppresses the harmful consequences of macrophage overactivation characterizing Hemophagocytic lymphohistiocytosis in 2 murine models.
JAK2 has a role in hepatocarcinogenesis through regulating critical inflammatory pathways
nitration of JAK2 may act as an inhibitory counterpart to phosphorylation activation, reflecting a very localized break on the progression of GH signal transduction processes spanning JAK (zeige JAK3 Antikörper)-STAT (zeige STAT1 Antikörper)-AKT (zeige AKT1 Antikörper) interactions
Janus kinase 2 (JAK2) gene polymorphism is a potential marker for milk production traits in cattle
Results indicate that SNPs in STAT5A (zeige STAT5A Antikörper) and JAK2 genes were associated with somatic cell count and score in milk and cytokines but none of the SNP was associated with milk production traits suggesting an important role in immunity.
Methionine promoted casein synthesis, and this may be mediated by enhanced intracellular substrate availability and by activating JAK2-STAT5 (zeige STAT5A Antikörper) and mTOR (zeige FRAP1 Antikörper) signaling pathways.
SNPs in JAK2 and STAT5B (zeige STAT5B Antikörper) are associated with mastitis susceptibility in Chinese Holstein cattle
Localized changes in the state of nitration of regulatory phosphorylation domains of JAK2 in caveoLAE during inflammation suggest a unique mechanism through which discrete signal transduction switching might occur in the liver
This gene product is a protein tyrosine kinase involved in a specific subset of cytokine receptor signaling pathways. It has been found to be constituitively associated with the prolactin receptor and is required for responses to gamma interferon. Mice that do not express an active protein for this gene exhibit embryonic lethality associated with the absence of definitive erythropoiesis.
, PTK JAK2b
, protein tyrosine kinase JAK2b
, tyrosine-protein kinase JAK2
, Janus kinase 2 (a protein tyrosine kinase)
, tyrosine kinase