anti-Maus IL6ST Antikörper für Enzyme Immunoassay

Recommended IL6ST Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) Antikörper
  • CD130
  • CDW130
  • GP130
  • IL-6RB
  • 5133400A03Rik
  • AA389424
  • BB405851
  • D13Ertd699e
  • gp130
  • Ac1055
  • Gp130
  • Il-6rb
  • NCR
  • interleukin 6 signal transducer (gp130, oncostatin M receptor)
  • interleukin 6 signal transducer
  • neutrophil migration
  • IL6ST
  • Il6st
  • il6st
  • LOC100349330
  • NM
Reaktivität
Human, Maus
220
128
64
4
4
3
2
2
1
1
1
1
Wirt
Hamster
143
112
72
5
3
1
Klonalität
Monoklonal
Konjugat
Dieser IL6ST Antikörper ist unkonjugiert
21
17
14
14
14
13
12
11
11
11
10
8
7
5
4
4
3
3
3
3
3
2
2
2
2
2
2
2
2
1
1
1
Applikation
Enzyme Immunoassay (EIA), Flow Cytometry (FACS)
186
124
62
31
26
19
17
14
13
12
11
11
6
5
5
3
2
2
2
1
1
Hersteller
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Bilder

Produktnummer ABIN1105843
$ 401.50
Zzgl. Versandkosten $45.00

General

Antigen Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) Antikörper
Reaktivität Human, Maus
(220), (128), (64), (4), (4), (3), (2), (2), (1), (1), (1), (1)
Wirt Hamster
(143), (112), (72), (5), (3), (1)
Klonalität (Klon)
Monoklonal   ( )
Konjugat Dieser IL6ST Antikörper ist unkonjugiert
(21), (17), (14), (14), (14), (13), (12), (11), (11), (11), (10), (8), (7), (5), (4), (4), (3), (3), (3), (3), (3), (2), (2), (2), (2), (2), (2), (2), (2), (1), (1), (1)
Applikation Enzyme Immunoassay (EIA), Flow Cytometry (FACS)
(186), (124), (62), (31), (26), (19), (17), (14), (13), (12), (11), (11), (6), (5), (5), (3), (2), (2), (2), (1), (1)
Pubmed 4 Publikationen vorhanden
Hersteller Anmelden zum Anzeigen

Produktdetails anti-IL6ST Antikörper

Target Details IL6ST Anwendungsinformationen Handhabung Referenzen für anti-IL6ST Antikörper (ABIN1105843) Bilder
Kreuzreaktivität (Details) Species reactivity (tested):Human, mouse
Reinigung Protein G agarose
Immunogen Mouse CD130 transfected 293T cells
Klon HMb1
Isotyp IgG

Target Details IL6ST

Produktdetails anti-IL6ST Antikörper Anwendungsinformationen Handhabung Referenzen für anti-IL6ST Antikörper (ABIN1105843) Bilder zurück nach oben
Antigen
Andere Bezeichnung CD130 / IL6ST (IL6ST Antibody Abstract)
Hintergrund The interleukin-6 (IL-6) cytokine family, including IL-6, IL-11, leukemia inhibitory factor (LIF), oncostatin M (OSM), ciliary neurotrophic factor (CNTF), cardiotrophin-1 (CT-1), and B-cell stimulatory factor 3, are also known as gp130 cytokines because they all share gp130 as a common transducer protein within their functional receptor complexes. In the case of IL-6, binding of the ligand to its specific a-receptor (IL-6Ra/CD126) induces dimerization of gp130, activation of the gp130-associated Janus kinases Jak1, Jak2 and Tyk2 and phosphorylation of gp130 at cytoplasmic tyrosine residues. These phosphotyrosines serve as docking sites for SH2-domain-containing proteins such as STAT1, STAT3, the protein tyrosine phosphatase SHP2 and the suppressor of cytokine signaling 3 (SOCS3). The subsequently tyrosine phosphorylated STAT homo- or heterodimers translocate to the nucleus where they bind to enhancer sequences of IL-6-inducible genes. Both IL-6Ra and gp130 have soluble forms. Although soluble gp130 inhibits the effect of IL-6, the soluble IL-6Ra promotes the effect of IL-6.Synonyms: IL-6R-beta, IL6 receptor beta, Interleukin-6 receptor subunit beta
Gen-ID 10090
UniProt Q00560
Forschungsgebiet CD Antigens, Surface Receptors of Immune Cells
Pathways JAK-STAT Signalweg, Cellular Glucan Metabolic Process, Autophagie, Smooth Muscle Cell Migration

Anwendungsinformationen

Produktdetails anti-IL6ST Antikörper Target Details IL6ST Handhabung Referenzen für anti-IL6ST Antikörper (ABIN1105843) Bilder zurück nach oben
Applikationshinweise Optimal working dilution should be determined by the investigator.
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-IL6ST Antikörper Target Details IL6ST Anwendungsinformationen Referenzen für anti-IL6ST Antikörper (ABIN1105843) Bilder zurück nach oben
Konzentration 1.0 mg/mL
Buffer PBS containing 50 % glycerol, pH 7.2. Contains no preservatives.
Konservierungsmittel Without preservative
Handhabung Avoid repeated freezing and thawing.
Lagerung -20 °C
Informationen zur Lagerung Store (in aliquots) at -20 °C.

Referenzen für anti-IL6ST Antikörper (ABIN1105843)

Produktdetails anti-IL6ST Antikörper Target Details IL6ST Anwendungsinformationen Handhabung Bilder zurück nach oben
Allgemeine Veröffentlichungen

Matsuda, Hirano: "Establishment of the ELISA for murine soluble gp130, a signal transducer for the IL-6 family cytokine, and its detection in the ascitic fluids of tumor-bearing mice." in: Biochemical and biophysical research communications, Vol. 202, Issue 1, pp. 637-42, 1994

Matsuda, Yamanaka, Hirano: "Interleukin-6-induced tyrosine phosphorylation of multiple proteins in murine hematopoietic lineage cells." in: Biochemical and biophysical research communications, Vol. 200, Issue 2, pp. 821-8, 1994

Hirano, Matsuda, Nakajima: "Signal transduction through gp130 that is shared among the receptors for the interleukin 6 related cytokine subfamily." in: Stem cells (Dayton, Ohio), Vol. 12, Issue 3, pp. 262-77, 1994

Yin, Taga, Tsang, Yasukawa, Kishimoto, Yang: "Involvement of IL-6 signal transducer gp130 in IL-11-mediated signal transduction." in: Journal of immunology (Baltimore, Md. : 1950), Vol. 151, Issue 5, pp. 2555-61, 1993

Bilder

Produktdetails anti-IL6ST Antikörper Target Details IL6ST Anwendungsinformationen Handhabung Referenzen für anti-IL6ST Antikörper (ABIN1105843) zurück nach oben
Bilder des Herstellers
Flow Cytometry (FACS) image for anti-Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) antibody (ABIN1105843) anti-Interleukin 6 Signal Transducer (Gp130, Oncostatin M Receptor) (IL6ST) antibody