anti-Human IL2RG Antikörper für Immunohistochemistry (Paraffin-embedded Sections)

Recommended IL2RG Antibody (geliefert von: Anmelden zum Anzeigen )

Antigen
Interleukin 2 Receptor, gamma (IL2RG) Antikörper
  • Ab2-183
  • Cd132
  • CD132
  • CIDX
  • IL-2RG
  • IMD4
  • P64
  • SCIDX
  • SCIDX1
  • [g]c
  • gamma(c)
  • gc
  • interleukin 2 receptor, gamma
  • interleukin 2 receptor, gamma chain
  • IL2RG
  • il2rg
  • Il2rg
Epitop
AA 135-185
34
16
15
15
14
10
8
8
7
5
5
4
4
4
3
3
2
2
1
1
1
Reaktivität
Human, Maus, Ratte (Rattus)
145
95
29
2
1
Wirt
Kaninchen
90
58
51
4
Klonalität
Polyklonal
Konjugat
Dieser IL2RG Antikörper ist unkonjugiert
12
10
10
9
9
9
9
9
8
8
5
4
4
3
3
1
1
1
1
1
1
Applikation
Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
114
73
47
15
12
10
9
3
3
3
2
2
1
1
1
1
1
Optionen
Hersteller
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Hersteller Produkt- Nr.
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Bilder

Produktnummer ABIN2176981
$ 295.90
Zzgl. Versandkosten $45.00
Relevance Score ABIN Application Konjugat Host Isotype Epitope Hersteller Clonality References Details
1 ABIN2176992 IHC (p) WB HRP Rabbit IgG AA 135-185 Anmelden zum Anzeigen Polyclonal
1 ABIN2176986 IHC (p) WB Biotin Rabbit IgG AA 135-185 Anmelden zum Anzeigen Polyclonal

General

Antigen Interleukin 2 Receptor, gamma (IL2RG) Antikörper
Epitop AA 135-185
(34), (16), (15), (15), (14), (10), (8), (8), (7), (5), (5), (4), (4), (4), (3), (3), (2), (2), (1), (1), (1)
Reaktivität Human, Maus, Ratte (Rattus)
(145), (95), (29), (2), (1)
Wirt Kaninchen
(90), (58), (51), (4)
Klonalität
Polyklonal
Konjugat Dieser IL2RG Antikörper ist unkonjugiert
(12), (10), (10), (9), (9), (9), (9), (9), (8), (8), (5), (4), (4), (3), (3), (1), (1), (1), (1), (1), (1)
Applikation Immunofluorescence (Paraffin-embedded Sections) (IF (p)), Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)), Western Blotting (WB)
(114), (73), (47), (15), (12), (10), (9), (3), (3), (3), (2), (2), (1), (1), (1), (1), (1)
Hersteller Anmelden zum Anzeigen

Produktdetails anti-IL2RG Antikörper

Target Details IL2RG Anwendungsinformationen Handhabung Bilder
Reinigung Purified by Protein A.
Immunogen KLH conjugated synthetic peptide derived from human IL-2R gamma
Isotyp IgG

Target Details IL2RG

Produktdetails anti-IL2RG Antikörper Anwendungsinformationen Handhabung Bilder zurück nach oben
Antigen
Andere Bezeichnung Il-2r gamma (IL2RG Antibody Abstract)
Hintergrund

Interleukin 2 (IL2) receptor gamma chain (IL5212R gamma) is a cell surface glycoprotein expressed by a variety of leukocytes including T cells, B cells, NK cells, monocytes, macrophages, and neutrophils. IL2R gamma is also known as CD132, common cytokine receptor gamma chain, and gamma c. IL2R gamma forms complexes with other cell surface proteins including CD25 (IL2R alpha), CD122 (IL2R beta), CD124 (IL4R alpha), CD127 (IL7R), and others. IL2R gamma complexed with other cell surface proteins forms receptors for the cytokines IL2, IL4, IL7, IL9, and IL15. Acting through the IL2R gamma containing complexes, these cytokines regulate lymphocyte development and activation. Chemical cross linking experiments reveal that IL2R gamma is able to bind cytokines only when complexed with these other cell surface proteins. In addition to interacting with other cell surface glycoproteins, IL2R gamma associates with several cytoplasmic tyrosine kinases including JAK3 (Janus Kinase 3), JAK1, Syc, and Lyc. Cytokine binding to the IL2R gamma containing receptor complexes activates these tyrosine kinases. Once activated, these tyrosine kinases phosphorylate their associated receptors, creating docking sites for signaling molecules such as PI 3 kinase. The activated tyrosine kinases also phosphorylate downstream regulators including STAT3 (Signal Transducer and Activator of Transcription 3), STAT5, and STAT6. The various cytokines that bind to IL2R gamma containing receptor complexes exert their effects through unique repertoires of cytoplasmic signaling molecules. IL2, IL7, and IL9 exert their effects through cascades, which activate STAT3 and STAT5, while IL4 activates STAT6. IL2 and IL15 exert their effects through cascades, which activate the MAP kinase cascade. IL7 exerts its effects through a cascade that results in VDJ immunoglobulin gene rearrangement.

Subcellular location: Extracellular

Synonyms: P64, CIDX, IMD4, CD132, SCIDX, IL-2RG, SCIDX1, Cytokine receptor common subunit gamma, Interleukin-2 receptor subunit gamma, IL-2 receptor subunit gamma, IL-2R subunit gamma, gammaC, IL2RG

Gen-ID 3561
UniProt P31785
Pathways JAK-STAT Signalweg, Growth Factor Binding

Anwendungsinformationen

Produktdetails anti-IL2RG Antikörper Target Details IL2RG Handhabung Bilder zurück nach oben
Applikationshinweise WB 1:100-1000
IHC-P 1:100-500
IF(IHC-P) 1:50-200
Beschränkungen Nur für Forschungszwecke einsetzbar

Handhabung

Produktdetails anti-IL2RG Antikörper Target Details IL2RG Anwendungsinformationen Bilder zurück nach oben
Format Liquid
Konzentration 1 μg/μL
Buffer Aqueous buffered solution containing 1 % BSA, 50 % glycerol and 0.09 % sodium azide.
Konservierungsmittel Sodium azide
Vorsichtsmaßnahmen This product contains Sodium azide: a POISONOUS AND HAZARDOUS SUBSTANCE, which should be handled by trained staff only.
Lagerung -20 °C
Informationen zur Lagerung Store at -20°C
Haltbarkeit 12 months

Bilder

Produktdetails anti-IL2RG Antikörper Target Details IL2RG Anwendungsinformationen Handhabung zurück nach oben
Bilder des Herstellers
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Interleukin 2 Receptor, gamma (IL2RG) (AA 135-185) antibody (ABIN2176981) Formalin-fixed and paraffin embedded human lung tissue labeled with Rabbit Anti-IL-2R...
Immunofluorescence (IF) image for anti-Interleukin 2 Receptor, gamma (IL2RG) (AA 135-185) antibody (ABIN2176981) Formalin-fixed and paraffin-embedded human lung labeled with Anti-IL-2R gamma Polyclo...
Western Blotting (WB) image for anti-Interleukin 2 Receptor, gamma (IL2RG) (AA 135-185) antibody (ABIN2176981) L1 rat spleen lysates L2 mouse heart lysates probed with Anti IL-2R gamma/CD132 Polyc...
Immunohistochemistry (Paraffin-embedded Sections) (IHC (p)) image for anti-Interleukin 2 Receptor, gamma (IL2RG) (AA 135-185) antibody (ABIN2176981) Formalin-fixed and paraffin embedded human lung tissue labeled with Rabbit Anti-IL-2R...
Flow Cytometry (FACS) image for anti-Interleukin 2 Receptor, gamma (IL2RG) (AA 135-185) antibody (ABIN2176981) Human U937 cells probed with IL-2R gamma Polyclonal Antibody, Unconjugated (green) a...